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Shooting for the moon: Using tissue-mimetic hydrogels to gain new insight on cancer biology and screen therapeutics

Shooting for the moon: Using tissue-mimetic hydrogels to gain new insight on cancer biology and screen therapeutics
Shooting for the moon: Using tissue-mimetic hydrogels to gain new insight on cancer biology and screen therapeutics

Tissue engineering holds great promise for advancing cancer research and achieving the goals of the Cancer Moonshot by providing better models for basic research and testing novel therapeutics. This paper focuses on the use of hydrogel biomaterials due to their unique ability to entrap cells in three-dimensional (3D) matrix that mimics tissues and can be programmed with physical and chemical cues to recreate key aspects of tumor microenvironments. The chemistry of some commonly used hydrogel platforms is discussed, and important examples of their use in tissue engineering 3D cancer models are highlighted. Challenges and opportunities for future research are also discussed.

2159-6859
427-441
Holt, Samantha E.
699799bf-c8c7-4ad8-bfa9-7d5a1e25ee42
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
Alge, Daniel L.
ab706e9b-724d-4549-940f-0575d96b8d11
Holt, Samantha E.
699799bf-c8c7-4ad8-bfa9-7d5a1e25ee42
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
Alge, Daniel L.
ab706e9b-724d-4549-940f-0575d96b8d11

Holt, Samantha E., Ward, E. Sally, Ober, Raimund J. and Alge, Daniel L. (2017) Shooting for the moon: Using tissue-mimetic hydrogels to gain new insight on cancer biology and screen therapeutics. MRS Communications, 7 (3), 427-441. (doi:10.1557/mrc.2017.86).

Record type: Article

Abstract

Tissue engineering holds great promise for advancing cancer research and achieving the goals of the Cancer Moonshot by providing better models for basic research and testing novel therapeutics. This paper focuses on the use of hydrogel biomaterials due to their unique ability to entrap cells in three-dimensional (3D) matrix that mimics tissues and can be programmed with physical and chemical cues to recreate key aspects of tumor microenvironments. The chemistry of some commonly used hydrogel platforms is discussed, and important examples of their use in tissue engineering 3D cancer models are highlighted. Challenges and opportunities for future research are also discussed.

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More information

Accepted/In Press date: 22 August 2017
e-pub ahead of print date: 7 September 2017
Published date: September 2017

Identifiers

Local EPrints ID: 423679
URI: http://eprints.soton.ac.uk/id/eprint/423679
ISSN: 2159-6859
PURE UUID: 305b8062-78a6-4848-97a3-b49ae141ec65
ORCID for E. Sally Ward: ORCID iD orcid.org/0000-0003-3232-7238
ORCID for Raimund J. Ober: ORCID iD orcid.org/0000-0002-1290-7430

Catalogue record

Date deposited: 27 Sep 2018 16:30
Last modified: 06 Jun 2024 02:04

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Contributors

Author: Samantha E. Holt
Author: E. Sally Ward ORCID iD
Author: Raimund J. Ober ORCID iD
Author: Daniel L. Alge

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