Shooting for the moon: Using tissue-mimetic hydrogels to gain new insight on cancer biology and screen therapeutics
Shooting for the moon: Using tissue-mimetic hydrogels to gain new insight on cancer biology and screen therapeutics
Tissue engineering holds great promise for advancing cancer research and achieving the goals of the Cancer Moonshot by providing better models for basic research and testing novel therapeutics. This paper focuses on the use of hydrogel biomaterials due to their unique ability to entrap cells in three-dimensional (3D) matrix that mimics tissues and can be programmed with physical and chemical cues to recreate key aspects of tumor microenvironments. The chemistry of some commonly used hydrogel platforms is discussed, and important examples of their use in tissue engineering 3D cancer models are highlighted. Challenges and opportunities for future research are also discussed.
427-441
Holt, Samantha E.
699799bf-c8c7-4ad8-bfa9-7d5a1e25ee42
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
Alge, Daniel L.
ab706e9b-724d-4549-940f-0575d96b8d11
September 2017
Holt, Samantha E.
699799bf-c8c7-4ad8-bfa9-7d5a1e25ee42
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
Alge, Daniel L.
ab706e9b-724d-4549-940f-0575d96b8d11
Holt, Samantha E., Ward, E. Sally, Ober, Raimund J. and Alge, Daniel L.
(2017)
Shooting for the moon: Using tissue-mimetic hydrogels to gain new insight on cancer biology and screen therapeutics.
MRS Communications, 7 (3), .
(doi:10.1557/mrc.2017.86).
Abstract
Tissue engineering holds great promise for advancing cancer research and achieving the goals of the Cancer Moonshot by providing better models for basic research and testing novel therapeutics. This paper focuses on the use of hydrogel biomaterials due to their unique ability to entrap cells in three-dimensional (3D) matrix that mimics tissues and can be programmed with physical and chemical cues to recreate key aspects of tumor microenvironments. The chemistry of some commonly used hydrogel platforms is discussed, and important examples of their use in tissue engineering 3D cancer models are highlighted. Challenges and opportunities for future research are also discussed.
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Accepted/In Press date: 22 August 2017
e-pub ahead of print date: 7 September 2017
Published date: September 2017
Identifiers
Local EPrints ID: 423679
URI: http://eprints.soton.ac.uk/id/eprint/423679
ISSN: 2159-6859
PURE UUID: 305b8062-78a6-4848-97a3-b49ae141ec65
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Date deposited: 27 Sep 2018 16:30
Last modified: 18 Mar 2024 03:48
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Author:
Samantha E. Holt
Author:
Daniel L. Alge
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