Engineered clearing agents for the selective depletion of antigen-specific antibodies
Engineered clearing agents for the selective depletion of antigen-specific antibodies
Here we have designed a novel class of engineered antibody-based reagents ('Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging.
Devanaboyina, Siva Charan
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Khare, Priyanka
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Challa, Dilip K.
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Ober, Raimund J.
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Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
31 May 2017
Devanaboyina, Siva Charan
4a79edaf-305f-4413-88b2-946e6284f98e
Khare, Priyanka
81db6b4f-ee24-4dcf-84e3-42b53f367cde
Challa, Dilip K.
433af413-17a0-4c55-b86f-21e4e5cedd6f
Ober, Raimund J.
31f4d47f-fb49-44f5-8ff6-87fc4aff3d36
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Devanaboyina, Siva Charan, Khare, Priyanka, Challa, Dilip K., Ober, Raimund J. and Ward, E. Sally
(2017)
Engineered clearing agents for the selective depletion of antigen-specific antibodies.
Nature Communications, 8, [15314].
(doi:10.1038/ncomms15314).
Abstract
Here we have designed a novel class of engineered antibody-based reagents ('Seldegs') that induce the selective degradation of antigen-specific antibodies. We demonstrate the rapid and specific clearance of antibodies recognizing the autoantigen, myelin oligodendrocyte glycoprotein and tumour target, HER2. Seldegs have considerable potential in multiple areas, including the treatment of antibody-mediated autoimmunity and diagnostic imaging.
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ncomms15314
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Accepted/In Press date: 20 March 2017
e-pub ahead of print date: 31 May 2017
Published date: 31 May 2017
Identifiers
Local EPrints ID: 423681
URI: http://eprints.soton.ac.uk/id/eprint/423681
PURE UUID: 3978ca4e-1265-4430-9760-26de904025b7
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Date deposited: 27 Sep 2018 16:30
Last modified: 18 Mar 2024 03:48
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Contributors
Author:
Siva Charan Devanaboyina
Author:
Priyanka Khare
Author:
Dilip K. Challa
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