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Associations between maternal physical activity in early and late pregnancy and offspring birth size: remote federated individual level meta-analysis from eight cohort studies

Associations between maternal physical activity in early and late pregnancy and offspring birth size: remote federated individual level meta-analysis from eight cohort studies
Associations between maternal physical activity in early and late pregnancy and offspring birth size: remote federated individual level meta-analysis from eight cohort studies
Objective

Evidence on the impact of leisure time physical activity (LTPA) in pregnancy on birth size is inconsistent. We aimed to examine the association between LTPA during early and late pregnancy and newborn anthropometric outcomes.

Design

Individual level meta‐analysis, which reduces heterogeneity across studies.

Setting

A consortium of eight population‐based studies (seven European and one US) comprising 72 694 participants.

Methods

Generalised linear models with consistent inclusion of confounders (gestational age, sex, parity, maternal age, education, ethnicity, BMI, smoking, and alcohol intake) were used to test associations between self‐reported LTPA at either early (8–18 weeks gestation) or late pregnancy (30+ weeks) and the outcomes. Results were pooled using random effects meta‐analyses.

Main outcome measures

Birth weight, large‐for‐gestational age (LGA), macrosomia, small‐for‐gestational age (SGA), % body fat, and ponderal index at birth.

Results

Late, but not early, gestation maternal moderate to vigorous physical activity (MVPA), vigorous activity, and LTPA energy expenditure were modestly inversely associated with BW, LGA, macrosomia, and ponderal index, without heterogeneity (all: I2 = 0%). For each extra hour/week of MVPA, RR for LGA and macrosomia were 0.97 (95% CI: 0.96, 0.98) and 0.96 (95% CI: 0.94, 0.98), respectively. Associations were only modestly reduced after additional adjustments for maternal BMI and gestational diabetes. No measure of LTPA was associated with risk for SGA.

Conclusions

Physical activity in late, but not early, pregnancy is consistently associated with modestly lower risk of LGA and macrosomia, but not SGA.

Tweetable abstract

In an individual participant meta‐analysis, late pregnancy moderate to vigorous physical activity modestly reduced birth size outcomes.
1470-0328
1-12
Pastorino, Silvio
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Bishop, T.
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Crozier, Sarah
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Granstrom, C.
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Kordas, K.
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Küpers, Leanne K.
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O'Brien, E.
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Polanska, K.
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Sauder, K.A.
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Zafarmand, M.H.
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Wilson, B.
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Agyemang, C.
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Burton, P.R.
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Cooper, Cyrus
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Corpeleijn, Eva
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Dabelea, Dana
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Hanke, W.
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Inskip, Hazel
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McAuliffe, F.M.
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Olsen, S.F.
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Vrijkotte, T.G.
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Brage, S.
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Kennedy, A.
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O'Gorman, D.
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Scherer, P.
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Wijndaele, K.
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Wareham, N.J.
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Desoye, Gernot
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Ong, K.K.
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Pastorino, Silvio
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Bishop, T.
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Crozier, Sarah
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Granstrom, C.
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Kordas, K.
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Küpers, Leanne K.
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O'Brien, E.
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Polanska, K.
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Sauder, K.A.
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Zafarmand, M.H.
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Wilson, B.
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Agyemang, C.
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Burton, P.R.
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Cooper, Cyrus
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Corpeleijn, Eva
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Dabelea, Dana
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Hanke, W.
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Inskip, Hazel
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McAuliffe, F.M.
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Olsen, S.F.
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Vrijkotte, T.G.
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Brage, S.
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Kennedy, A.
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O'Gorman, D.
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Scherer, P.
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Wijndaele, K.
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Wareham, N.J.
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Desoye, Gernot
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Ong, K.K.
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Pastorino, Silvio, Bishop, T., Crozier, Sarah, Granstrom, C., Kordas, K., Küpers, Leanne K., O'Brien, E., Polanska, K., Sauder, K.A., Zafarmand, M.H., Wilson, B., Agyemang, C., Burton, P.R., Cooper, Cyrus, Corpeleijn, Eva, Dabelea, Dana, Hanke, W., Inskip, Hazel, McAuliffe, F.M., Olsen, S.F., Vrijkotte, T.G., Brage, S., Kennedy, A., O'Gorman, D., Scherer, P., Wijndaele, K., Wareham, N.J., Desoye, Gernot and Ong, K.K. (2018) Associations between maternal physical activity in early and late pregnancy and offspring birth size: remote federated individual level meta-analysis from eight cohort studies. BJOG: An International Journal of Obstetrics & Gynaecology, 1-12. (doi:10.1111/1471-0528.15476).

Record type: Article

Abstract

Objective

Evidence on the impact of leisure time physical activity (LTPA) in pregnancy on birth size is inconsistent. We aimed to examine the association between LTPA during early and late pregnancy and newborn anthropometric outcomes.

Design

Individual level meta‐analysis, which reduces heterogeneity across studies.

Setting

A consortium of eight population‐based studies (seven European and one US) comprising 72 694 participants.

Methods

Generalised linear models with consistent inclusion of confounders (gestational age, sex, parity, maternal age, education, ethnicity, BMI, smoking, and alcohol intake) were used to test associations between self‐reported LTPA at either early (8–18 weeks gestation) or late pregnancy (30+ weeks) and the outcomes. Results were pooled using random effects meta‐analyses.

Main outcome measures

Birth weight, large‐for‐gestational age (LGA), macrosomia, small‐for‐gestational age (SGA), % body fat, and ponderal index at birth.

Results

Late, but not early, gestation maternal moderate to vigorous physical activity (MVPA), vigorous activity, and LTPA energy expenditure were modestly inversely associated with BW, LGA, macrosomia, and ponderal index, without heterogeneity (all: I2 = 0%). For each extra hour/week of MVPA, RR for LGA and macrosomia were 0.97 (95% CI: 0.96, 0.98) and 0.96 (95% CI: 0.94, 0.98), respectively. Associations were only modestly reduced after additional adjustments for maternal BMI and gestational diabetes. No measure of LTPA was associated with risk for SGA.

Conclusions

Physical activity in late, but not early, pregnancy is consistently associated with modestly lower risk of LGA and macrosomia, but not SGA.

Tweetable abstract

In an individual participant meta‐analysis, late pregnancy moderate to vigorous physical activity modestly reduced birth size outcomes.

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More information

Accepted/In Press date: 17 September 2018
e-pub ahead of print date: 19 September 2018

Identifiers

Local EPrints ID: 423694
URI: https://eprints.soton.ac.uk/id/eprint/423694
ISSN: 1470-0328
PURE UUID: b1e73c85-a754-4105-a578-709c132ac9cf
ORCID for Sarah Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749

Catalogue record

Date deposited: 27 Sep 2018 16:30
Last modified: 10 Dec 2019 01:53

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Contributors

Author: Silvio Pastorino
Author: T. Bishop
Author: Sarah Crozier ORCID iD
Author: C. Granstrom
Author: K. Kordas
Author: Leanne K. Küpers
Author: E. O'Brien
Author: K. Polanska
Author: K.A. Sauder
Author: M.H. Zafarmand
Author: B. Wilson
Author: C. Agyemang
Author: P.R. Burton
Author: Cyrus Cooper ORCID iD
Author: Eva Corpeleijn
Author: Dana Dabelea
Author: W. Hanke
Author: Hazel Inskip ORCID iD
Author: F.M. McAuliffe
Author: S.F. Olsen
Author: T.G. Vrijkotte
Author: S. Brage
Author: A. Kennedy
Author: D. O'Gorman
Author: P. Scherer
Author: K. Wijndaele
Author: N.J. Wareham
Author: Gernot Desoye
Author: K.K. Ong

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