Minimalistic in vitro systems for investigating tau pathology
Minimalistic in vitro systems for investigating tau pathology
Neurofibrillary tangles, formed of hyperphosphorylated, misfolded tau accumulations, are a pathological hallmark of neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia. The neuroanatomical localisation of tau pathology in AD brains of different disease stages suggests that tau tangle pathology is spreading throughout the brain along connected neuronal circuits. Pathogenic tau can act as a prion-like seed, inducing the misfolding of native tau and leading to disease propagation throughout the brain. However, it is not yet fully understood how tau spreads between individual neurons or brain regions.
Alzheimer’s disease, tauopathy, tau, prion-like propagation, microfluidic devices
Hallinan, Grace
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Pitera, Aleksandra, Paulina
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Patel, Prutha
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West, Jonathan
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Deinhardt, Katrin
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Hallinan, Grace
5549f978-4afd-4b1c-a4e1-6fe6530d3573
Pitera, Aleksandra, Paulina
6cf28d67-483b-494b-8323-c01a64c24f71
Patel, Prutha
fb6d4749-ff22-420b-a1fa-b6a6fcaabad8
West, Jonathan
f1c2e060-16c3-44c0-af70-242a1c58b968
Deinhardt, Katrin
5f4fe23b-2317-499f-ba6d-e639a4885dc1
Hallinan, Grace, Pitera, Aleksandra, Paulina, Patel, Prutha, West, Jonathan and Deinhardt, Katrin
(2018)
Minimalistic in vitro systems for investigating tau pathology.
Journal of Neuroscience Methods.
(doi:10.1016/j.jneumeth.2018.09.032).
Abstract
Neurofibrillary tangles, formed of hyperphosphorylated, misfolded tau accumulations, are a pathological hallmark of neurodegenerative diseases such as Alzheimer’s disease (AD) and frontotemporal dementia. The neuroanatomical localisation of tau pathology in AD brains of different disease stages suggests that tau tangle pathology is spreading throughout the brain along connected neuronal circuits. Pathogenic tau can act as a prion-like seed, inducing the misfolding of native tau and leading to disease propagation throughout the brain. However, it is not yet fully understood how tau spreads between individual neurons or brain regions.
Text
1-s2.0-S0165027018302991-main
- Accepted Manuscript
More information
Accepted/In Press date: 28 September 2018
e-pub ahead of print date: 29 September 2018
Keywords:
Alzheimer’s disease, tauopathy, tau, prion-like propagation, microfluidic devices
Identifiers
Local EPrints ID: 423763
URI: http://eprints.soton.ac.uk/id/eprint/423763
ISSN: 0165-0270
PURE UUID: 9a250b0d-955c-4daa-b1c6-85d6ce8679b0
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Date deposited: 01 Oct 2018 16:30
Last modified: 16 Mar 2024 07:07
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Contributors
Author:
Grace Hallinan
Author:
Aleksandra, Paulina Pitera
Author:
Prutha Patel
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