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The value of tumour debulking for patients with extensive multi-organ metastatic colorectal cancer

The value of tumour debulking for patients with extensive multi-organ metastatic colorectal cancer
The value of tumour debulking for patients with extensive multi-organ metastatic colorectal cancer

Local treatment of metastases by surgical resection or other ablative therapies is technically feasible in an increasing number of patients with multi-organ metastatic cancer. This results in a growing debate on whether patients with extensive disease, that is traditionally deemed unresectable, may benefit from local treatment of metastases when added to standard palliative systemic therapy. For selected patients with oligometastatic colorectal cancer, local treatment of metastases has become the standard of care based on retrospective reports showing long-term survival rates. In addition to systemic therapy, preliminary evidence suggests that patients with extensive metastatic colorectal cancer may also benefit from local treatment. Here, we present the future perspectives based on the available literature on local treatment approaches in colorectal cancer.

Journal Article
0959-8049
160-164
Gootjes, Elske C.
3c308c3f-bd02-4c04-a414-77f9d5a3e88c
Bakkerus, Lotte
64fde50b-295d-49f9-9938-e12c96817b35
Ten Tije, Albert J.
62565c14-5f29-4f29-8da5-2714ee57c87d
Witteveen, Petronella O.
874db304-c42a-4a5d-bcc1-618c474b7e17
Buffart, Tineke E.
30a8028b-c3c2-47ae-aacf-c5bc61919cc3
Bridgewater, John A.
22a97d4c-b9df-4f88-b413-d3193d2d14b7
Primrose, John N.
d85f3b28-24c6-475f-955b-ec457a3f9185
Verhoef, Cornelis
d4549415-5b8e-47cb-9743-50fa7d90bdcf
Verheul, Henk M.W.
63913ea6-ba5a-4696-8167-29d7710535ab
Gootjes, Elske C.
3c308c3f-bd02-4c04-a414-77f9d5a3e88c
Bakkerus, Lotte
64fde50b-295d-49f9-9938-e12c96817b35
Ten Tije, Albert J.
62565c14-5f29-4f29-8da5-2714ee57c87d
Witteveen, Petronella O.
874db304-c42a-4a5d-bcc1-618c474b7e17
Buffart, Tineke E.
30a8028b-c3c2-47ae-aacf-c5bc61919cc3
Bridgewater, John A.
22a97d4c-b9df-4f88-b413-d3193d2d14b7
Primrose, John N.
d85f3b28-24c6-475f-955b-ec457a3f9185
Verhoef, Cornelis
d4549415-5b8e-47cb-9743-50fa7d90bdcf
Verheul, Henk M.W.
63913ea6-ba5a-4696-8167-29d7710535ab

Gootjes, Elske C., Bakkerus, Lotte, Ten Tije, Albert J., Witteveen, Petronella O., Buffart, Tineke E., Bridgewater, John A., Primrose, John N., Verhoef, Cornelis and Verheul, Henk M.W. (2018) The value of tumour debulking for patients with extensive multi-organ metastatic colorectal cancer. European Journal of Cancer, 103, 160-164. (doi:10.1016/j.ejca.2018.07.012).

Record type: Article

Abstract

Local treatment of metastases by surgical resection or other ablative therapies is technically feasible in an increasing number of patients with multi-organ metastatic cancer. This results in a growing debate on whether patients with extensive disease, that is traditionally deemed unresectable, may benefit from local treatment of metastases when added to standard palliative systemic therapy. For selected patients with oligometastatic colorectal cancer, local treatment of metastases has become the standard of care based on retrospective reports showing long-term survival rates. In addition to systemic therapy, preliminary evidence suggests that patients with extensive metastatic colorectal cancer may also benefit from local treatment. Here, we present the future perspectives based on the available literature on local treatment approaches in colorectal cancer.

Text
Value of Tumor Debulking in extensive mCRC Eur J Can accepted version - Accepted Manuscript
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More information

Accepted/In Press date: 8 July 2018
e-pub ahead of print date: 19 September 2018
Published date: 1 November 2018
Keywords: Journal Article

Identifiers

Local EPrints ID: 423764
URI: http://eprints.soton.ac.uk/id/eprint/423764
ISSN: 0959-8049
PURE UUID: b2d5f45e-cd23-43dc-a323-1eab37675d92
ORCID for John N. Primrose: ORCID iD orcid.org/0000-0002-2069-7605

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Date deposited: 01 Oct 2018 16:30
Last modified: 16 Mar 2024 07:07

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Contributors

Author: Elske C. Gootjes
Author: Lotte Bakkerus
Author: Albert J. Ten Tije
Author: Petronella O. Witteveen
Author: Tineke E. Buffart
Author: John A. Bridgewater
Author: Cornelis Verhoef
Author: Henk M.W. Verheul

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