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Computational investigation of ripple dynamics in biofilms in flowing systems

Computational investigation of ripple dynamics in biofilms in flowing systems
Computational investigation of ripple dynamics in biofilms in flowing systems
Biofilms are collections of microorganisms that aggregate using a self-produced matrix of extracellular polymeric substance (EPS). It has been broadly demonstrated that many microbial infections in the body, including dental plaque, involve biofilms. While studying experimental models of biofilms relevant to mechanical removal of oral biofilms, distinct ripple patterns have been observed. In this paper, we describe a multiphase model used to approximate the dynamics of the biofilm removal process. We show that the fully nonlinear model provides a better representation of the experimental data than the linear stability analysis. In particular, we show that the full model more accurately reflects the relationship between the apparent wavelength and the external forcing velocities – especially at mid-to-low velocities where the linear theory neglects important interactions. Finally, the model provides a framework where the removal process (presumably governed by highly nonlinear behavior) can be studied.
Biofilm, multiphase model, Kelvin-Helmholtz
0006-3495
Cogan, N.G.
a13ad860-fb80-4ccd-b695-08b18095df0c
Li, J.
e0ade5f8-f879-43ff-81bc-0661aadccee1
Fabbri, S.
c93b6166-2117-48a9-9a88-b23a62c7b5da
Stoodley, P.
08614665-92a9-4466-806e-20c6daeb483f
Cogan, N.G.
a13ad860-fb80-4ccd-b695-08b18095df0c
Li, J.
e0ade5f8-f879-43ff-81bc-0661aadccee1
Fabbri, S.
c93b6166-2117-48a9-9a88-b23a62c7b5da
Stoodley, P.
08614665-92a9-4466-806e-20c6daeb483f

Cogan, N.G., Li, J., Fabbri, S. and Stoodley, P. (2018) Computational investigation of ripple dynamics in biofilms in flowing systems. Biophysical Journal. (doi:10.1016/j.bpj.2018.08.016).

Record type: Article

Abstract

Biofilms are collections of microorganisms that aggregate using a self-produced matrix of extracellular polymeric substance (EPS). It has been broadly demonstrated that many microbial infections in the body, including dental plaque, involve biofilms. While studying experimental models of biofilms relevant to mechanical removal of oral biofilms, distinct ripple patterns have been observed. In this paper, we describe a multiphase model used to approximate the dynamics of the biofilm removal process. We show that the fully nonlinear model provides a better representation of the experimental data than the linear stability analysis. In particular, we show that the full model more accurately reflects the relationship between the apparent wavelength and the external forcing velocities – especially at mid-to-low velocities where the linear theory neglects important interactions. Finally, the model provides a framework where the removal process (presumably governed by highly nonlinear behavior) can be studied.

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Accepted/In Press date: 14 August 2018
e-pub ahead of print date: 21 August 2018
Keywords: Biofilm, multiphase model, Kelvin-Helmholtz

Identifiers

Local EPrints ID: 423782
URI: http://eprints.soton.ac.uk/id/eprint/423782
ISSN: 0006-3495
PURE UUID: b5ef06be-afc5-4acd-a6b1-5e8217e75361
ORCID for P. Stoodley: ORCID iD orcid.org/0000-0001-6069-273X

Catalogue record

Date deposited: 01 Oct 2018 16:30
Last modified: 10 Dec 2019 05:13

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Contributors

Author: N.G. Cogan
Author: J. Li
Author: S. Fabbri
Author: P. Stoodley ORCID iD

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