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The presentation, management and outcome of inflammatory breast cancer cases in the UK: data from a multi-centre retrospective review

The presentation, management and outcome of inflammatory breast cancer cases in the UK: data from a multi-centre retrospective review
The presentation, management and outcome of inflammatory breast cancer cases in the UK: data from a multi-centre retrospective review
Objectives: inflammatory Breast cancer (IBC) is a rare but aggressive form of breast cancer. Its incidence and behaviour in the UK is poorly characterised. We collected retrospective data from hospitals in the UK and Ireland to describe the presentation, pathology, treatment and clinical course of IBC in the UK.

Materials and Methods: patients with IBC diagnosed between 1997 -2014 at fourteen UK and Irish hospitals were identified from local breast unit databases. Patient characteristics, tumour pathology and stage, and details of surgical, systemic and radiotherapy treatment and follow-up data were collected from electronic patient records and medical notes.

Results: this retrospective review identified 445 patients with IBC accounting for 0.4-1.8% of invasive breast cancer cases. Median follow-up was 4.2 years. 53.2% of tumours were grade 3, 56.2% were oestrogen receptor positive, 31.3% were HER2 positive and 25.1% were triple negative. 20.7% of patients had distant metastases at presentation. Despite trimodality treatment in 86.4%, 40.1% of stage III patients developed distant metastases. Five-year overall survival (OS) was 61.0% for stage III and 21.4% for stage IV patients.


Conclusions: this is the largest series of UK IBC patients reported to date. It indicates a lower incidence than in American series, but confirms that IBC has a high risk of recurrence with poor survival despite contemporary multi- modality therapy. A national strategy is required to facilitate translational research into this aggressive disease.

Key words: Inflammatory breast cancer, Breast, Cancer, Large cohort

0960-9776
133-141
Cutress, Ramsey
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Copson, Ellen
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Shaaban, Abeer M.
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Maishman, Thomas
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Moseley, P.M.
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Mckenzie, Hayley
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Bradbury, Jennifer
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Brzezinska, M.
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Chan, S.Y.T.
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Ching, J.
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Danial, I.
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Dall, B.
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Kerin, M.
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Lowery, A.J.
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Macpherson, I.R.
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Romics, L.
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Sawyer, E.
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Sharmat, N.
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Sircar, T.
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Vidya, R.
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Pan, Y.
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Rea, D.
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Jones, L.
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Eccles, Diana
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Berditchevski, Fedor
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Cutress, Ramsey
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Copson, Ellen
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Shaaban, Abeer M.
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Maishman, Thomas
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Moseley, P.M.
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Mckenzie, Hayley
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Bradbury, Jennifer
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Brzezinska, M.
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Chan, S.Y.T.
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Ching, J.
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Danial, I.
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Dall, B.
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Kerin, M.
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Lowery, A.J.
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Macpherson, I.R.
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Romics, L.
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Sawyer, E.
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Sharmat, N.
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Sircar, T.
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Vidya, R.
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Pan, Y.
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Rea, D.
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Jones, L.
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Eccles, Diana
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Berditchevski, Fedor
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Cutress, Ramsey, Copson, Ellen, Shaaban, Abeer M., Maishman, Thomas, Moseley, P.M., Mckenzie, Hayley, Bradbury, Jennifer, Brzezinska, M., Chan, S.Y.T., Ching, J., Danial, I., Dall, B., Kerin, M., Lowery, A.J., Macpherson, I.R., Romics, L., Sawyer, E., Sharmat, N., Sircar, T., Vidya, R., Pan, Y., Rea, D., Jones, L., Eccles, Diana and Berditchevski, Fedor (2018) The presentation, management and outcome of inflammatory breast cancer cases in the UK: data from a multi-centre retrospective review. The Breast, 42, 133-141. (doi:10.1016/j.breast.2018.09.003).

Record type: Article

Abstract

Objectives: inflammatory Breast cancer (IBC) is a rare but aggressive form of breast cancer. Its incidence and behaviour in the UK is poorly characterised. We collected retrospective data from hospitals in the UK and Ireland to describe the presentation, pathology, treatment and clinical course of IBC in the UK.

Materials and Methods: patients with IBC diagnosed between 1997 -2014 at fourteen UK and Irish hospitals were identified from local breast unit databases. Patient characteristics, tumour pathology and stage, and details of surgical, systemic and radiotherapy treatment and follow-up data were collected from electronic patient records and medical notes.

Results: this retrospective review identified 445 patients with IBC accounting for 0.4-1.8% of invasive breast cancer cases. Median follow-up was 4.2 years. 53.2% of tumours were grade 3, 56.2% were oestrogen receptor positive, 31.3% were HER2 positive and 25.1% were triple negative. 20.7% of patients had distant metastases at presentation. Despite trimodality treatment in 86.4%, 40.1% of stage III patients developed distant metastases. Five-year overall survival (OS) was 61.0% for stage III and 21.4% for stage IV patients.


Conclusions: this is the largest series of UK IBC patients reported to date. It indicates a lower incidence than in American series, but confirms that IBC has a high risk of recurrence with poor survival despite contemporary multi- modality therapy. A national strategy is required to facilitate translational research into this aggressive disease.

Key words: Inflammatory breast cancer, Breast, Cancer, Large cohort

Text
IBC UK Experience Copson August 2018 Final unmarked - Accepted Manuscript
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More information

Accepted/In Press date: 10 September 2018
e-pub ahead of print date: 15 September 2018
Published date: December 2018

Identifiers

Local EPrints ID: 424195
URI: http://eprints.soton.ac.uk/id/eprint/424195
ISSN: 0960-9776
PURE UUID: a8e36623-60d3-45e2-8ba7-0ca24e3e04dc
ORCID for Diana Eccles: ORCID iD orcid.org/0000-0002-9935-3169

Catalogue record

Date deposited: 05 Oct 2018 11:34
Last modified: 26 Nov 2021 05:29

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Contributors

Author: Ramsey Cutress
Author: Ellen Copson
Author: Abeer M. Shaaban
Author: Thomas Maishman
Author: P.M. Moseley
Author: Hayley Mckenzie
Author: Jennifer Bradbury
Author: M. Brzezinska
Author: S.Y.T. Chan
Author: J. Ching
Author: I. Danial
Author: B. Dall
Author: M. Kerin
Author: A.J. Lowery
Author: I.R. Macpherson
Author: L. Romics
Author: E. Sawyer
Author: N. Sharmat
Author: T. Sircar
Author: R. Vidya
Author: Y. Pan
Author: D. Rea
Author: L. Jones
Author: Diana Eccles ORCID iD
Author: Fedor Berditchevski

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