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Body composition and body mass index in Duchenne dystrophy: role of dietary intake

Body composition and body mass index in Duchenne dystrophy: role of dietary intake
Body composition and body mass index in Duchenne dystrophy: role of dietary intake

Introduction:

In Duchenne muscular dystrophy (DMD) muscle is replaced by adipose tissue. The role of dietary intake (DI) in DMD has not been evaluated. We examined body composition , BMI and adequacy of DI in patients with DMD and evaluated the influence of DI on body composition.

Methods:

Patients (n=101; age 3 to 18 years; BMI 11.8 to 29.5 kg/m2) completed a dietary recall to determine DI and underwent dual‐energy x‐ray absorptiometry to determine body composition.

Results:

Preschool‐age and school‐age boys with DMD had high total energy intake. Protein intake/kg exceeded recommendations. As age increased, the percentage of boys with abnormal BMI and fat mass increased, while lean mass decreased. Dietary intake did not predict body fat or lean mass.

Discussion:

Age dependent changes in BD in boys with DMD may be due to endogenous metabolic factors related to the underlying disease process and to disease‐related mobility impairments.
0148-639X
295-302
Bernabe García, Mariela
0874ce55-deb3-46ef-9b81-d2cea7bd99cc
Rodríguez Cruz, Maricela
c80047bf-a00e-44c8-b1ae-23bc1ba1d01f
Atilano, Salvador
cd47f71b-f422-4fb9-abe3-a7d4d0bfc08b
Cruz-Guzmán, Oriana Rocío
0e366bd6-56d4-4ec5-bb53-f7ce5c40c921
Almeida-Becerril, Tomás
63b494ac-635a-4786-a568-66ee643e5a33
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Gonzalez, Julia
70293aec-ae38-4cc6-ada2-7ade0c8c55e0
Bernabe García, Mariela
0874ce55-deb3-46ef-9b81-d2cea7bd99cc
Rodríguez Cruz, Maricela
c80047bf-a00e-44c8-b1ae-23bc1ba1d01f
Atilano, Salvador
cd47f71b-f422-4fb9-abe3-a7d4d0bfc08b
Cruz-Guzmán, Oriana Rocío
0e366bd6-56d4-4ec5-bb53-f7ce5c40c921
Almeida-Becerril, Tomás
63b494ac-635a-4786-a568-66ee643e5a33
Calder, Philip C.
1797e54f-378e-4dcb-80a4-3e30018f07a6
Gonzalez, Julia
70293aec-ae38-4cc6-ada2-7ade0c8c55e0

Bernabe García, Mariela, Rodríguez Cruz, Maricela, Atilano, Salvador, Cruz-Guzmán, Oriana Rocío, Almeida-Becerril, Tomás, Calder, Philip C. and Gonzalez, Julia (2019) Body composition and body mass index in Duchenne dystrophy: role of dietary intake. Muscle & Nerve, 59 (3), 295-302. (doi:10.1002/mus.26340).

Record type: Article

Abstract


Introduction:

In Duchenne muscular dystrophy (DMD) muscle is replaced by adipose tissue. The role of dietary intake (DI) in DMD has not been evaluated. We examined body composition , BMI and adequacy of DI in patients with DMD and evaluated the influence of DI on body composition.

Methods:

Patients (n=101; age 3 to 18 years; BMI 11.8 to 29.5 kg/m2) completed a dietary recall to determine DI and underwent dual‐energy x‐ray absorptiometry to determine body composition.

Results:

Preschool‐age and school‐age boys with DMD had high total energy intake. Protein intake/kg exceeded recommendations. As age increased, the percentage of boys with abnormal BMI and fat mass increased, while lean mass decreased. Dietary intake did not predict body fat or lean mass.

Discussion:

Age dependent changes in BD in boys with DMD may be due to endogenous metabolic factors related to the underlying disease process and to disease‐related mobility impairments.

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Clean.Manuscript-Revised-Rodriguez-Cruz (1) - Accepted Manuscript
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More information

Accepted/In Press date: 4 September 2018
e-pub ahead of print date: 8 September 2018
Published date: 1 March 2019

Identifiers

Local EPrints ID: 424232
URI: http://eprints.soton.ac.uk/id/eprint/424232
ISSN: 0148-639X
PURE UUID: 53d66f04-d2bf-4ea5-88d3-33ce82005ff7
ORCID for Philip C. Calder: ORCID iD orcid.org/0000-0002-6038-710X

Catalogue record

Date deposited: 05 Oct 2018 11:35
Last modified: 26 Nov 2021 06:27

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Contributors

Author: Mariela Bernabe García
Author: Maricela Rodríguez Cruz
Author: Salvador Atilano
Author: Oriana Rocío Cruz-Guzmán
Author: Tomás Almeida-Becerril
Author: Julia Gonzalez

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