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Investigating immune priming in the auditory system as a cause of variable outcomes after cochlear implantation

Investigating immune priming in the auditory system as a cause of variable outcomes after cochlear implantation
Investigating immune priming in the auditory system as a cause of variable outcomes after cochlear implantation
Cochlear implants (CIs) are auditory prostheses which replace the function of damaged sensory cells in the cochlea. Despite the success of CIs, our evidence shows some individuals have sub-optimal improvement in hearing function. We hypothesise that one source of variability arises from the priming of microglia and macrophages in response to inflammatory insults. Priming describes a change whereby microglia and macrophages exhibit an exaggerated inflammatory response to a second stimulus having previously been exposed to an initial ‘trigger’ stimulus. We will investigate whether a primary insult likely experienced by CI patients (noise exposure), causes priming. The presence and immunoreactivity of inflammatory markers will be measured from tissue collected from the cochlea and central auditory pathway of noise-exposed and control (sham-exposed) CBA mice, that we have auditory brainstem recordings (ABR) from. Whether priming leads to a heightened inflammatory response upon a secondary insult (cochlear implantation) will be determined by measuring cytokine production. This altered immune response could lead to the less favourable outcomes seen in CI users. Understanding whether microglia and macrophages become primed after initial insults and the effect on the subsequent inflammatory response, will contribute to determining whether robust control of inflammation will improve hearing outcomes after CI.
Cochlear implant, microglial priming, Hearing Loss
Hough, K.
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Sanderson, A.
79d72ecf-7722-4a39-be5f-a041ba423c2b
Anderson, L.
dfd72ba0-7cdb-4ae7-b7a8-27f5b80de74e
Impey, B.
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Verschuur, C.
5e15ee1c-3a44-4dbe-ad43-ec3b50111e41
Newman, T. A.
322290cb-2e9c-445d-a047-00b1bea39a25
Hough, K.
4ab6ce34-81be-4bff-bdc1-bdd22bbb0ace
Sanderson, A.
79d72ecf-7722-4a39-be5f-a041ba423c2b
Anderson, L.
dfd72ba0-7cdb-4ae7-b7a8-27f5b80de74e
Impey, B.
a9527785-a335-479b-81a9-a820c5e40efc
Verschuur, C.
5e15ee1c-3a44-4dbe-ad43-ec3b50111e41
Newman, T. A.
322290cb-2e9c-445d-a047-00b1bea39a25

Hough, K., Sanderson, A., Anderson, L., Impey, B., Verschuur, C. and Newman, T. A. (2018) Investigating immune priming in the auditory system as a cause of variable outcomes after cochlear implantation. The Immune to Brain Axis - SoNG, Avenue Campus, University of Southampton , Southampton, United Kingdom. 12 Sep 2018.

Record type: Conference or Workshop Item (Poster)

Abstract

Cochlear implants (CIs) are auditory prostheses which replace the function of damaged sensory cells in the cochlea. Despite the success of CIs, our evidence shows some individuals have sub-optimal improvement in hearing function. We hypothesise that one source of variability arises from the priming of microglia and macrophages in response to inflammatory insults. Priming describes a change whereby microglia and macrophages exhibit an exaggerated inflammatory response to a second stimulus having previously been exposed to an initial ‘trigger’ stimulus. We will investigate whether a primary insult likely experienced by CI patients (noise exposure), causes priming. The presence and immunoreactivity of inflammatory markers will be measured from tissue collected from the cochlea and central auditory pathway of noise-exposed and control (sham-exposed) CBA mice, that we have auditory brainstem recordings (ABR) from. Whether priming leads to a heightened inflammatory response upon a secondary insult (cochlear implantation) will be determined by measuring cytokine production. This altered immune response could lead to the less favourable outcomes seen in CI users. Understanding whether microglia and macrophages become primed after initial insults and the effect on the subsequent inflammatory response, will contribute to determining whether robust control of inflammation will improve hearing outcomes after CI.

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Published date: 13 September 2018
Venue - Dates: The Immune to Brain Axis - SoNG, Avenue Campus, University of Southampton , Southampton, United Kingdom, 2018-09-12 - 2018-09-12
Keywords: Cochlear implant, microglial priming, Hearing Loss

Identifiers

Local EPrints ID: 424233
URI: http://eprints.soton.ac.uk/id/eprint/424233
PURE UUID: 939ab698-77b8-4bf5-b5cf-e3c5a8683052
ORCID for K. Hough: ORCID iD orcid.org/0000-0002-5160-2517
ORCID for T. A. Newman: ORCID iD orcid.org/0000-0002-3727-9258

Catalogue record

Date deposited: 05 Oct 2018 11:35
Last modified: 22 Nov 2021 03:17

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Contributors

Author: K. Hough ORCID iD
Author: A. Sanderson
Author: L. Anderson
Author: B. Impey
Author: C. Verschuur
Author: T. A. Newman ORCID iD

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