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Stability of polysomnography for one year and longer in children with sickle cell disease

Stability of polysomnography for one year and longer in children with sickle cell disease
Stability of polysomnography for one year and longer in children with sickle cell disease

Study Objectives: Serious morbidity may be linked to sleep disordered breathing (SDB) among children with sickle cell disease (SCD). We investigated the stability of polysomnography (PSG) results among children not having acute complications of SCD. Methods: Two PSGs were performed on a subsample of 63 children 4 to 18 years of age from the Sleep and Asthma Cohort Study. All had Hb SS or HbSβ0 disease. Two PSGs were compared for 45 subjects. Excluded from comparison were 18 children who had begun transfusions or hydroxyurea, had an adenotonsillectomy between the PSGs, or had a pain crisis or the acute chest syndrome within 3 months of the second PSG. Sleep disordered breathing was identifi ed using 2 thresholds for the apnea hypopnea index (AHI): ≥ 2 or ≥ 5 respiratory events per hour. Results: Ages were 12.3 yrs ± 4.0, BMI, 18.2 ± 3.2. Interval between PSGs was 581 ± 119 days (19.1 ± 3.9 months). Ten of 45 changed from ≥ 2 events per hour to < 2; 3 of 45 from < 2 to ≥ 2; 7 of 45 had ≥ 2 on both nights. Six of 45 changed from ≥ 5 to < 5, 2 of 45 from < 5 to ≥ 5, and 1 had ≥ 5 on both nights (McNemar χ2, p = 0.09, and p = 0.29). Conclusions: In the absence of acute SCD complications, overnight PSG usually remains stable or improves over a 12- to 30-month period. Only 6.7% subjects, or fewer, had AHI on a subsequent PSG that would re-classify the child as having SDB not identifi ed in the earlier PSG.

Obstructive sleep apnea, Polysomnography, Sickle cell disease
1550-9389
535-539
Mullin, Jonathan E.
c384f1ed-1239-45e8-b8aa-bd0faecff7a7
Cooper, Benjamin P.
bbcc13ef-f529-4a2f-8e0e-f8f2cde2f240
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Rosen, Carol L.
3a8d9aa4-397d-47f6-8791-3df3e42eb1a5
Strunk, Robert C.
014a33a8-1e21-4ee9-8b32-2cfb453f033d
DeBaun, Michael R.
76559153-80c6-4642-bdf8-672a75570dfe
Redline, Susan
3466f7f2-aa34-4c87-b8f1-37e039f6f0bd
Kemp, James S.
0400b7e9-1283-4546-b573-6fae7068b5a0
Mullin, Jonathan E.
c384f1ed-1239-45e8-b8aa-bd0faecff7a7
Cooper, Benjamin P.
bbcc13ef-f529-4a2f-8e0e-f8f2cde2f240
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Rosen, Carol L.
3a8d9aa4-397d-47f6-8791-3df3e42eb1a5
Strunk, Robert C.
014a33a8-1e21-4ee9-8b32-2cfb453f033d
DeBaun, Michael R.
76559153-80c6-4642-bdf8-672a75570dfe
Redline, Susan
3466f7f2-aa34-4c87-b8f1-37e039f6f0bd
Kemp, James S.
0400b7e9-1283-4546-b573-6fae7068b5a0

Mullin, Jonathan E., Cooper, Benjamin P., Kirkham, Fenella J., Rosen, Carol L., Strunk, Robert C., DeBaun, Michael R., Redline, Susan and Kemp, James S. (2012) Stability of polysomnography for one year and longer in children with sickle cell disease. Journal of Clinical Sleep Medicine, 8 (5), 535-539. (doi:10.5664/jcsm.2150).

Record type: Article

Abstract

Study Objectives: Serious morbidity may be linked to sleep disordered breathing (SDB) among children with sickle cell disease (SCD). We investigated the stability of polysomnography (PSG) results among children not having acute complications of SCD. Methods: Two PSGs were performed on a subsample of 63 children 4 to 18 years of age from the Sleep and Asthma Cohort Study. All had Hb SS or HbSβ0 disease. Two PSGs were compared for 45 subjects. Excluded from comparison were 18 children who had begun transfusions or hydroxyurea, had an adenotonsillectomy between the PSGs, or had a pain crisis or the acute chest syndrome within 3 months of the second PSG. Sleep disordered breathing was identifi ed using 2 thresholds for the apnea hypopnea index (AHI): ≥ 2 or ≥ 5 respiratory events per hour. Results: Ages were 12.3 yrs ± 4.0, BMI, 18.2 ± 3.2. Interval between PSGs was 581 ± 119 days (19.1 ± 3.9 months). Ten of 45 changed from ≥ 2 events per hour to < 2; 3 of 45 from < 2 to ≥ 2; 7 of 45 had ≥ 2 on both nights. Six of 45 changed from ≥ 5 to < 5, 2 of 45 from < 5 to ≥ 5, and 1 had ≥ 5 on both nights (McNemar χ2, p = 0.09, and p = 0.29). Conclusions: In the absence of acute SCD complications, overnight PSG usually remains stable or improves over a 12- to 30-month period. Only 6.7% subjects, or fewer, had AHI on a subsequent PSG that would re-classify the child as having SDB not identifi ed in the earlier PSG.

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More information

Published date: 2012
Keywords: Obstructive sleep apnea, Polysomnography, Sickle cell disease

Identifiers

Local EPrints ID: 424255
URI: http://eprints.soton.ac.uk/id/eprint/424255
ISSN: 1550-9389
PURE UUID: b437e1f0-5513-4a6d-b4ac-3714d981df4d
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 05 Oct 2018 11:35
Last modified: 26 Feb 2022 02:37

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Contributors

Author: Jonathan E. Mullin
Author: Benjamin P. Cooper
Author: Carol L. Rosen
Author: Robert C. Strunk
Author: Michael R. DeBaun
Author: Susan Redline
Author: James S. Kemp

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