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Enuresis associated with sleep disordered breathing in children with sickle cell anemia

Enuresis associated with sleep disordered breathing in children with sickle cell anemia
Enuresis associated with sleep disordered breathing in children with sickle cell anemia

Purpose: Enuresis and sleep disordered breathing are common among children with sickle cell anemia. We evaluated whether enuresis is associated with sleep disordered breathing in children with sickle cell anemia. Materials and Methods: Baseline data were used from a multicenter prospective cohort study of 221 unselected children with sickle cell anemia. A questionnaire was used to evaluate, by parental report during the previous month, the presence of enuresis and its severity. Overnight polysomnography was used to determine the presence of sleep disordered breathing by the number of obstructive apneas and/or hypopneas per hour of sleep. Logistic and ordinal regression models were used to evaluate the association of sleep disordered breathing and enuresis. Results: The mean age of participants was 10.1 years (median 10.0, range 4 to 19). Enuresis occurred in 38.9% of participants and was significantly associated with an obstructive apnea-hypopnea index of 2 or more per hour after adjusting for age and gender (OR 2.19; 95% CI 1.09, 4.40; p = 0.03). Enuresis severity was associated with obstructive apneas and hypopneas with 3% or more desaturation 2 or more times per hour with and without habitual snoring (OR 3.23; 95% CI 1.53, 6.81; p = 0.001 and OR 2.07; 95% CI 1.09, 3.92; p = 0.03, respectively). Conclusions: In this unselected group of children with sickle cell anemia, sleep disordered breathing was associated with enuresis. Results of this study support that children with sickle cell anemia who present with enuresis should be evaluated by a pulmonologist for sleep disordered breathing.

anemia, enuresis, sickle cell, sleep
0022-5347
1572-1576
Lehmann, Gloria C.
cc597024-5ac4-4f8d-87eb-3f0e2b06f19f
Bell, Teal R.
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Kirkham, Fenella J.
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Gavlak, Johanna C.
7bdc0a38-81bb-4b26-8356-272860d9209e
Ferguson, Tekeda F.
2b3097cc-7594-40f5-8d89-d574ce97e1e8
Strunk, Robert C.
014a33a8-1e21-4ee9-8b32-2cfb453f033d
Austin, Paul
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Rosen, Carol L.
3a8d9aa4-397d-47f6-8791-3df3e42eb1a5
Marshall, Melanie J.
fe58e080-7009-4113-afcf-bdeb05394728
Wilkey, Olu
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Rodeghier, Mark J.
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Warner, John O.
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Debaun, Michael R.
76559153-80c6-4642-bdf8-672a75570dfe
Lehmann, Gloria C.
cc597024-5ac4-4f8d-87eb-3f0e2b06f19f
Bell, Teal R.
7ff58abf-787b-4e52-adf8-e1c48f235b40
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Gavlak, Johanna C.
7bdc0a38-81bb-4b26-8356-272860d9209e
Ferguson, Tekeda F.
2b3097cc-7594-40f5-8d89-d574ce97e1e8
Strunk, Robert C.
014a33a8-1e21-4ee9-8b32-2cfb453f033d
Austin, Paul
e1a6e0fd-9923-4282-9f3d-e09230c19f93
Rosen, Carol L.
3a8d9aa4-397d-47f6-8791-3df3e42eb1a5
Marshall, Melanie J.
fe58e080-7009-4113-afcf-bdeb05394728
Wilkey, Olu
adb1eb81-8a3f-4966-820e-2d4d2d78a476
Rodeghier, Mark J.
f1141bb4-70fb-4ff1-b12a-fb58e7bd8864
Warner, John O.
bc2e44c6-7e76-4336-a4ad-e31434fb4c26
Debaun, Michael R.
76559153-80c6-4642-bdf8-672a75570dfe

Lehmann, Gloria C., Bell, Teal R., Kirkham, Fenella J., Gavlak, Johanna C., Ferguson, Tekeda F., Strunk, Robert C., Austin, Paul, Rosen, Carol L., Marshall, Melanie J., Wilkey, Olu, Rodeghier, Mark J., Warner, John O. and Debaun, Michael R. (2012) Enuresis associated with sleep disordered breathing in children with sickle cell anemia. The Journal of Urology, 188 (4 SUPPL.), 1572-1576. (doi:10.1016/j.juro.2012.02.021).

Record type: Article

Abstract

Purpose: Enuresis and sleep disordered breathing are common among children with sickle cell anemia. We evaluated whether enuresis is associated with sleep disordered breathing in children with sickle cell anemia. Materials and Methods: Baseline data were used from a multicenter prospective cohort study of 221 unselected children with sickle cell anemia. A questionnaire was used to evaluate, by parental report during the previous month, the presence of enuresis and its severity. Overnight polysomnography was used to determine the presence of sleep disordered breathing by the number of obstructive apneas and/or hypopneas per hour of sleep. Logistic and ordinal regression models were used to evaluate the association of sleep disordered breathing and enuresis. Results: The mean age of participants was 10.1 years (median 10.0, range 4 to 19). Enuresis occurred in 38.9% of participants and was significantly associated with an obstructive apnea-hypopnea index of 2 or more per hour after adjusting for age and gender (OR 2.19; 95% CI 1.09, 4.40; p = 0.03). Enuresis severity was associated with obstructive apneas and hypopneas with 3% or more desaturation 2 or more times per hour with and without habitual snoring (OR 3.23; 95% CI 1.53, 6.81; p = 0.001 and OR 2.07; 95% CI 1.09, 3.92; p = 0.03, respectively). Conclusions: In this unselected group of children with sickle cell anemia, sleep disordered breathing was associated with enuresis. Results of this study support that children with sickle cell anemia who present with enuresis should be evaluated by a pulmonologist for sleep disordered breathing.

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Published date: October 2012
Keywords: anemia, enuresis, sickle cell, sleep

Identifiers

Local EPrints ID: 424257
URI: http://eprints.soton.ac.uk/id/eprint/424257
ISSN: 0022-5347
PURE UUID: dc040c1e-c2cf-4b6d-82d1-b662f6a55cf4
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 05 Oct 2018 11:35
Last modified: 19 Nov 2019 01:51

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Contributors

Author: Gloria C. Lehmann
Author: Teal R. Bell
Author: Fenella J. Kirkham ORCID iD
Author: Johanna C. Gavlak
Author: Tekeda F. Ferguson
Author: Robert C. Strunk
Author: Paul Austin
Author: Carol L. Rosen
Author: Melanie J. Marshall
Author: Olu Wilkey
Author: Mark J. Rodeghier
Author: John O. Warner
Author: Michael R. Debaun

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