Subcortical and cerebellar volumetric deficits in paediatric sickle cell anaemia
Subcortical and cerebellar volumetric deficits in paediatric sickle cell anaemia
Sickle cell anaemia (SCA) is associated with silent cerebral infarction (SCI), affecting white and cortical grey matter, but there are few data on subcortical volumes. We analysed retrospective magnetic resonance imaging (MRI) data in 26 SCA patients and 20 controls, comparing mean subcortical volumes between three groups: controls, SCA with SCI (n = 13) and SCA without visible abnormality (n = 13). Specific volumetric differences were found in the hippocampus, amygdala, pallidum, caudate, putamen, thalamus, and cerebellum. This is the first study to demonstrate subcortical volume change in SCA, with the most severe volumetric deficits occurring in children with SCI seen on MRI.
Magnetic resonance imaging, Sickle cell anaemia, Sickle cell radiology, Stroke
373-376
Kawadler, Jamie M.
425d1643-3623-453a-9db0-6505d8065e70
Clayden, Jonathan D.
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Kirkham, Fenella J.
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Cox, Timothy C.
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Saunders, Dawn E.
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Clark, Chris A.
2aa6957f-c5e9-4cdc-ac2d-7565e8c6eae8
November 2013
Kawadler, Jamie M.
425d1643-3623-453a-9db0-6505d8065e70
Clayden, Jonathan D.
1f384d07-9591-4dd4-80e0-50244283d314
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Cox, Timothy C.
f53c3285-98ba-44b0-9967-50a0e9a8d37b
Saunders, Dawn E.
9d877417-e3ee-493d-9477-a66b47c3455d
Clark, Chris A.
2aa6957f-c5e9-4cdc-ac2d-7565e8c6eae8
Kawadler, Jamie M., Clayden, Jonathan D., Kirkham, Fenella J., Cox, Timothy C., Saunders, Dawn E. and Clark, Chris A.
(2013)
Subcortical and cerebellar volumetric deficits in paediatric sickle cell anaemia.
British Journal of Haematology, 163 (3), .
(doi:10.1111/bjh.12496).
Abstract
Sickle cell anaemia (SCA) is associated with silent cerebral infarction (SCI), affecting white and cortical grey matter, but there are few data on subcortical volumes. We analysed retrospective magnetic resonance imaging (MRI) data in 26 SCA patients and 20 controls, comparing mean subcortical volumes between three groups: controls, SCA with SCI (n = 13) and SCA without visible abnormality (n = 13). Specific volumetric differences were found in the hippocampus, amygdala, pallidum, caudate, putamen, thalamus, and cerebellum. This is the first study to demonstrate subcortical volume change in SCA, with the most severe volumetric deficits occurring in children with SCI seen on MRI.
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e-pub ahead of print date: 27 July 2013
Published date: November 2013
Keywords:
Magnetic resonance imaging, Sickle cell anaemia, Sickle cell radiology, Stroke
Identifiers
Local EPrints ID: 424260
URI: http://eprints.soton.ac.uk/id/eprint/424260
ISSN: 0007-1048
PURE UUID: 996b9336-90d8-4b86-af39-4e8b69351afa
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Date deposited: 05 Oct 2018 11:35
Last modified: 16 Mar 2024 03:22
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Contributors
Author:
Jamie M. Kawadler
Author:
Jonathan D. Clayden
Author:
Timothy C. Cox
Author:
Dawn E. Saunders
Author:
Chris A. Clark
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