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Precursors of executive function in infants with sickle cell anemia

Precursors of executive function in infants with sickle cell anemia
Precursors of executive function in infants with sickle cell anemia

Executive dysfunction occurs in sickle cell anemia, but there are few early data. Infants with sickle cell anemia (n = 14) and controls (n = 14) performed the "A-not-B" and Object Retrieval search tasks, measuring precursors of executive function at 9 and 12 months. Significant group differences were not found. However, for the A-not-B task, 7 of 11 sickle cell anemia infants scored in the lower 2 performance categories at 9 months, but only 1 at 12 months (P =.024); controls obtained scores at 12 months that were statistically comparable to the scores they had already obtained at 9 months. On the Object Retrieval task, 9- and 12-month controls showed comparable scores, whereas infants with sickle cell anemia continued to improve (P =.027); at 9 months, those with lower hemoglobin oxygen saturation passed fewer trials (Rs = 0.670, P =.024) and took longer to obtain the toy (Rs = -0.664, P =.013). Subtle delays in acquiring developmental skills may underlie abnormal executive function in childhood.

anemia, cognition, dysfunction, executive, function, neuropsychology, sickle cell
0883-0738
1197-1202
Hogan, Alexandra M.
fca40672-6980-46b5-883f-e85b71cf07f1
Telfer, Paul T.
4f57150d-6011-4689-82ab-d32aa65f32c7
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Haan, Michelle De
72c96996-93a0-4629-9c61-4efc7c6e697d
Hogan, Alexandra M.
fca40672-6980-46b5-883f-e85b71cf07f1
Telfer, Paul T.
4f57150d-6011-4689-82ab-d32aa65f32c7
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Haan, Michelle De
72c96996-93a0-4629-9c61-4efc7c6e697d

Hogan, Alexandra M., Telfer, Paul T., Kirkham, Fenella J. and Haan, Michelle De (2013) Precursors of executive function in infants with sickle cell anemia. Journal of Child Neurology, 28 (10), 1197-1202. (doi:10.1177/0883073812453495).

Record type: Article

Abstract

Executive dysfunction occurs in sickle cell anemia, but there are few early data. Infants with sickle cell anemia (n = 14) and controls (n = 14) performed the "A-not-B" and Object Retrieval search tasks, measuring precursors of executive function at 9 and 12 months. Significant group differences were not found. However, for the A-not-B task, 7 of 11 sickle cell anemia infants scored in the lower 2 performance categories at 9 months, but only 1 at 12 months (P =.024); controls obtained scores at 12 months that were statistically comparable to the scores they had already obtained at 9 months. On the Object Retrieval task, 9- and 12-month controls showed comparable scores, whereas infants with sickle cell anemia continued to improve (P =.027); at 9 months, those with lower hemoglobin oxygen saturation passed fewer trials (Rs = 0.670, P =.024) and took longer to obtain the toy (Rs = -0.664, P =.013). Subtle delays in acquiring developmental skills may underlie abnormal executive function in childhood.

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More information

Accepted/In Press date: 8 June 2012
Published date: October 2013
Keywords: anemia, cognition, dysfunction, executive, function, neuropsychology, sickle cell

Identifiers

Local EPrints ID: 424265
URI: https://eprints.soton.ac.uk/id/eprint/424265
ISSN: 0883-0738
PURE UUID: 621d61cd-60b7-466a-95dd-9e3498c70b4e
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

Catalogue record

Date deposited: 05 Oct 2018 11:35
Last modified: 20 Jul 2019 01:05

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