Genetic contributions to Trail Making Test performance in UK Biobank
Genetic contributions to Trail Making Test performance in UK Biobank
The Trail Making Test (TMT) is a widely used test of executive function and has been thought to be strongly associated with general cognitive function. We examined the genetic architecture of the TMT and its shared genetic aetiology with other tests of cognitive function in 23 821 participants from UK Biobank. The single-nucleotide polymorphism-based heritability estimates for trail-making measures were 7.9% (part A), 22.4% (part B) and 17.6% (part B−part A). Significant genetic correlations were identified between trail-making measures and verbal-numerical reasoning (rg>0.6), general cognitive function (rg>0.6), processing speed (rg>0.7) and memory (rg>0.3). Polygenic profile analysis indicated considerable shared genetic aetiology between trail making, general cognitive function, processing speed and memory (standardized β between 0.03 and 0.08). These results suggest that trail making is both phenotypically and genetically strongly associated with general cognitive function and processing speed.
1575-1583
Hagenaars, S.P.
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Cox, S.R.
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Hill, W.D.
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Davies, G.
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Liewald, D.C.M.
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Harris, S.E.
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McIntosh, A.M.
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Gale, C.R.
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Deary, I.J.
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CHARGE consortium Cognitive Working Group
1 July 2018
Hagenaars, S.P.
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Cox, S.R.
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Hill, W.D.
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Davies, G.
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Liewald, D.C.M.
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Harris, S.E.
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McIntosh, A.M.
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Gale, C.R.
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Deary, I.J.
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Hagenaars, S.P., Cox, S.R., Hill, W.D., Davies, G., Liewald, D.C.M., Harris, S.E., McIntosh, A.M., Gale, C.R. and Deary, I.J.
,
CHARGE consortium Cognitive Working Group
(2018)
Genetic contributions to Trail Making Test performance in UK Biobank.
Molecular Psychiatry, 23 (7), .
(doi:10.1038/mp.2017.189).
Abstract
The Trail Making Test (TMT) is a widely used test of executive function and has been thought to be strongly associated with general cognitive function. We examined the genetic architecture of the TMT and its shared genetic aetiology with other tests of cognitive function in 23 821 participants from UK Biobank. The single-nucleotide polymorphism-based heritability estimates for trail-making measures were 7.9% (part A), 22.4% (part B) and 17.6% (part B−part A). Significant genetic correlations were identified between trail-making measures and verbal-numerical reasoning (rg>0.6), general cognitive function (rg>0.6), processing speed (rg>0.7) and memory (rg>0.3). Polygenic profile analysis indicated considerable shared genetic aetiology between trail making, general cognitive function, processing speed and memory (standardized β between 0.03 and 0.08). These results suggest that trail making is both phenotypically and genetically strongly associated with general cognitive function and processing speed.
Text
mp2017189
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More information
Accepted/In Press date: 13 July 2017
e-pub ahead of print date: 19 September 2017
Published date: 1 July 2018
Identifiers
Local EPrints ID: 424355
URI: http://eprints.soton.ac.uk/id/eprint/424355
ISSN: 1359-4184
PURE UUID: d8018ce1-044d-47da-9b1f-a29043ac7f8a
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Date deposited: 05 Oct 2018 11:36
Last modified: 18 Mar 2024 02:41
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Contributors
Author:
S.P. Hagenaars
Author:
S.R. Cox
Author:
W.D. Hill
Author:
G. Davies
Author:
D.C.M. Liewald
Author:
S.E. Harris
Author:
A.M. McIntosh
Author:
I.J. Deary
Corporate Author: CHARGE consortium Cognitive Working Group
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