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Surfactant proteins A and D: trimerized innate immunity proteins with an affinity for viral fusion proteins

Surfactant proteins A and D: trimerized innate immunity proteins with an affinity for viral fusion proteins
Surfactant proteins A and D: trimerized innate immunity proteins with an affinity for viral fusion proteins
Innate recognition of viruses is an essential part of the immune response to viral pathogens. This is integral to the maintenance of healthy lungs, which are free from infection and efficient at gaseous exchange. An important component of innate immunity in identifying viruses is the family of C-type collagen containing lectins, also known as collectins. These secreted, soluble proteins are pattern recognition receptors (PRRs) which recognise pathogen-associated molecular patterns (PAMPs), including viral glycoproteins. These innate immune proteins are composed of trimerized units which oligomerise into higher-order structures and facilitate clearance of viral pathogens through multiple mechanisms. Similarly, many viral surface proteins form trimeric configurations, despite not showing primary protein sequence similarities across virus classes and families they belong to. In this review, we discuss the role of lung collectins surfactant proteins A and D (SP-A and SP-D) in viral recognition. Particularly, we focus on the structural similarity and complementarity of these trimeric collectins with the trimeric viral fusion proteins with which, we hypothesise, they have elegantly co-evolved. Recombinant versions of these innate immune proteins may have therapeutic potential in a range of infectious and inflammatory lung diseases including as anti-viral therapeutics.
Collectins, surfactant proteins, innate immunity, Virus, fusion proteins, trimeric proteins
1662-811X
1-16
Watson, Alastair
9eb79329-8d32-4ed4-b8b9-d720883e8042
Phipps, Maximillian
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Clark, Howard
70550b6d-3bd7-47c6-8c02-4f43f37d5213
Skylaris, Chris-Kriton
8f593d13-3ace-4558-ba08-04e48211af61
Madsen, Jens
b5d8ae35-00ac-4d19-930e-d8ddec497359
Watson, Alastair
9eb79329-8d32-4ed4-b8b9-d720883e8042
Phipps, Maximillian
290febb8-7f0a-4bda-9944-96594d6343d2
Clark, Howard
70550b6d-3bd7-47c6-8c02-4f43f37d5213
Skylaris, Chris-Kriton
8f593d13-3ace-4558-ba08-04e48211af61
Madsen, Jens
b5d8ae35-00ac-4d19-930e-d8ddec497359

Watson, Alastair, Phipps, Maximillian, Clark, Howard, Skylaris, Chris-Kriton and Madsen, Jens (2018) Surfactant proteins A and D: trimerized innate immunity proteins with an affinity for viral fusion proteins. Journal of Innate Immunity, 1-16. (doi:10.1159/000492974).

Record type: Review

Abstract

Innate recognition of viruses is an essential part of the immune response to viral pathogens. This is integral to the maintenance of healthy lungs, which are free from infection and efficient at gaseous exchange. An important component of innate immunity in identifying viruses is the family of C-type collagen containing lectins, also known as collectins. These secreted, soluble proteins are pattern recognition receptors (PRRs) which recognise pathogen-associated molecular patterns (PAMPs), including viral glycoproteins. These innate immune proteins are composed of trimerized units which oligomerise into higher-order structures and facilitate clearance of viral pathogens through multiple mechanisms. Similarly, many viral surface proteins form trimeric configurations, despite not showing primary protein sequence similarities across virus classes and families they belong to. In this review, we discuss the role of lung collectins surfactant proteins A and D (SP-A and SP-D) in viral recognition. Particularly, we focus on the structural similarity and complementarity of these trimeric collectins with the trimeric viral fusion proteins with which, we hypothesise, they have elegantly co-evolved. Recombinant versions of these innate immune proteins may have therapeutic potential in a range of infectious and inflammatory lung diseases including as anti-viral therapeutics.

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SP-A and SP-D and virus review - revised 310718 w figures - Accepted Manuscript
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492974 - Version of Record
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More information

Accepted/In Press date: 16 August 2018
e-pub ahead of print date: 5 October 2018
Keywords: Collectins, surfactant proteins, innate immunity, Virus, fusion proteins, trimeric proteins

Identifiers

Local EPrints ID: 424682
URI: http://eprints.soton.ac.uk/id/eprint/424682
ISSN: 1662-811X
PURE UUID: 1171b123-a67d-4fbc-91b0-5b09246dc400
ORCID for Chris-Kriton Skylaris: ORCID iD orcid.org/0000-0003-0258-3433
ORCID for Jens Madsen: ORCID iD orcid.org/0000-0003-1664-7645

Catalogue record

Date deposited: 05 Oct 2018 11:40
Last modified: 22 Nov 2021 06:45

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Contributors

Author: Alastair Watson
Author: Maximillian Phipps
Author: Howard Clark
Author: Jens Madsen ORCID iD

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