Cardiac autonomic activity during sleep in high altitude resident children compared to lowland residents

Abstract

Study Objectives: We aimed to characterize heart rate variability (HRV) during sleep in Andean children native to high altitude (HA) compared to age, gender and genetic ancestry-similar low altitude (LA) children. We hypothesized that the hypoxic burden of sleep at HA could induce variation in HRV. As children have otherwise healthy cardiovascular systems, such alterations could provide early markers of later cardiovascular disease.

Methods: Twenty-six LA (14F) and 18 HA (8F) children underwent a single night of attended polysomnography. Sleep parameters and HRV indices were measured. Linear mixed models were used to assess HRV differences across sleep stage and altitude group.

Results: All children showed marked fluctuations in HRV parameters across sleep stages, with higher vagal activity during NREM sleep and greater variability of the heart rate during REM. Moreover, HA children showed higher very low frequency HRV in REM sleep and, after adjusting for heart rate, higher low to high frequency ratio in REM sleep compared to children living at lower altitude.

Conclusions: We confirmed previous findings of a stage-dependent modulation of HRV in Andean children living at both high and low altitudes. Moreover, we showed subtle alteration of HRV in sleep in HA children, with intriguing differences in the very low frequency domain during REM sleep. Whether these differences are the results of an adaptation to high altitude living, or an indirect effect of differences in oxyhaemoglobin saturation remain unclear, and further research is required to address these questions.

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Identifiers

ORCID for Catherine Hill: orcid.org/0000-0003-2372-5904

ORCID for David Simpson: orcid.org/0000-0001-9072-5088

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