The University of Southampton
University of Southampton Institutional Repository

Cardiac autonomic activity during sleep in high altitude resident children compared to lowland residents

Cardiac autonomic activity during sleep in high altitude resident children compared to lowland residents
Cardiac autonomic activity during sleep in high altitude resident children compared to lowland residents
Study Objectives: We aimed to characterize heart rate variability (HRV) during sleep in Andean children native to high altitude (HA) compared to age, gender and genetic ancestry-similar low altitude (LA) children. We hypothesized that the hypoxic burden of sleep at HA could induce variation in HRV. As children have otherwise healthy cardiovascular systems, such alterations could provide early markers of later cardiovascular disease.

Methods: Twenty-six LA (14F) and 18 HA (8F) children underwent a single night of attended polysomnography. Sleep parameters and HRV indices were measured. Linear mixed models were used to assess HRV differences across sleep stage and altitude group.

Results: All children showed marked fluctuations in HRV parameters across sleep stages, with higher vagal activity during NREM sleep and greater variability of the heart rate during REM. Moreover, HA children showed higher very low frequency HRV in REM sleep and, after adjusting for heart rate, higher low to high frequency ratio in REM sleep compared to children living at lower altitude.

Conclusions: We confirmed previous findings of a stage-dependent modulation of HRV in Andean children living at both high and low altitudes. Moreover, we showed subtle alteration of HRV in sleep in HA children, with intriguing differences in the very low frequency domain during REM sleep. Whether these differences are the results of an adaptation to high altitude living, or an indirect effect of differences in oxyhaemoglobin saturation remain unclear, and further research is required to address these questions.
0161-8105
Hill, Catherine
867cd0a0-dabc-4152-b4bf-8e9fbc0edf8d
Bucks, Romola Starr
16dbcd29-a84d-4573-87ba-0c6468dcef97
Cellini, Nicola
89459ee7-2f6d-4371-acce-de4ed44c5e47
Motamedi, Shayan
0244c29f-e17f-45ad-9a5f-4f4b96158195
Carroll, Annette
5e9925c5-7c8c-400f-a426-1576879bfd9e
Heathcote, Kate
411fe403-d854-4759-a0cc-cea97fcff519
Webster, Rebecca
0882cf98-333d-428c-9bbf-cdf0fae3d3f2
Simpson, David
53674880-f381-4cc9-8505-6a97eeac3c2a
Hill, Catherine
867cd0a0-dabc-4152-b4bf-8e9fbc0edf8d
Bucks, Romola Starr
16dbcd29-a84d-4573-87ba-0c6468dcef97
Cellini, Nicola
89459ee7-2f6d-4371-acce-de4ed44c5e47
Motamedi, Shayan
0244c29f-e17f-45ad-9a5f-4f4b96158195
Carroll, Annette
5e9925c5-7c8c-400f-a426-1576879bfd9e
Heathcote, Kate
411fe403-d854-4759-a0cc-cea97fcff519
Webster, Rebecca
0882cf98-333d-428c-9bbf-cdf0fae3d3f2
Simpson, David
53674880-f381-4cc9-8505-6a97eeac3c2a

Hill, Catherine, Bucks, Romola Starr, Cellini, Nicola, Motamedi, Shayan, Carroll, Annette, Heathcote, Kate, Webster, Rebecca and Simpson, David (2018) Cardiac autonomic activity during sleep in high altitude resident children compared to lowland residents. Sleep, 41 (12). (doi:10.1093/sleep/zsy181).

Record type: Article

Abstract

Study Objectives: We aimed to characterize heart rate variability (HRV) during sleep in Andean children native to high altitude (HA) compared to age, gender and genetic ancestry-similar low altitude (LA) children. We hypothesized that the hypoxic burden of sleep at HA could induce variation in HRV. As children have otherwise healthy cardiovascular systems, such alterations could provide early markers of later cardiovascular disease.

Methods: Twenty-six LA (14F) and 18 HA (8F) children underwent a single night of attended polysomnography. Sleep parameters and HRV indices were measured. Linear mixed models were used to assess HRV differences across sleep stage and altitude group.

Results: All children showed marked fluctuations in HRV parameters across sleep stages, with higher vagal activity during NREM sleep and greater variability of the heart rate during REM. Moreover, HA children showed higher very low frequency HRV in REM sleep and, after adjusting for heart rate, higher low to high frequency ratio in REM sleep compared to children living at lower altitude.

Conclusions: We confirmed previous findings of a stage-dependent modulation of HRV in Andean children living at both high and low altitudes. Moreover, we showed subtle alteration of HRV in sleep in HA children, with intriguing differences in the very low frequency domain during REM sleep. Whether these differences are the results of an adaptation to high altitude living, or an indirect effect of differences in oxyhaemoglobin saturation remain unclear, and further research is required to address these questions.

Text
Sleep - Accepted Manuscript
Download (607kB)

More information

Accepted/In Press date: 1 August 2018
e-pub ahead of print date: 13 September 2018
Published date: December 2018

Identifiers

Local EPrints ID: 424792
URI: http://eprints.soton.ac.uk/id/eprint/424792
ISSN: 0161-8105
PURE UUID: 38535d04-91b6-4aa0-8569-69c71a68241c
ORCID for Catherine Hill: ORCID iD orcid.org/0000-0003-2372-5904

Catalogue record

Date deposited: 05 Oct 2018 11:46
Last modified: 18 Feb 2021 16:52

Export record

Altmetrics

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×