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Urinary excretion of sulfur metabolites and risk of cardiovascular events and all-cause mortality in the general population

Urinary excretion of sulfur metabolites and risk of cardiovascular events and all-cause mortality in the general population
Urinary excretion of sulfur metabolites and risk of cardiovascular events and all-cause mortality in the general population

Thiosulfate and sulfate are natural dietary constituents, as well as oxidative metabolites of hydrogen sulfide (H2S), a gaseous signaling molecule with cardiovascular protective properties. Urinary thiosulfate and sulfate excretion are associated with favorable disease outcome in high-risk patients. In our large, general population based cohort neither thiosulfate, nor sulfate excretion is associated with risk of cardiovascular events. However, sulfate, but not thiosulfate, excretion, is inversely associated with risk of all-cause mortality. This strong association leads to the hypothesis that urinary sulfate excretion is a clinically relevant biomarker of physiological disturbance and may even serve as a target for nutritional intervention to promote healthy aging.

Journal Article
1523-0864
1999-2010
van den Born, Joost
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Koning, Anne M.
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Frenay, Anne-Roos
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Bachtler, Matthias
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Riphagen, Ineke
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Minovic, Isidor
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Feelisch, Martin
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Dekker, Marinda
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Bulthuis, Marian
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Gansevoort, Ron
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Hillebrands, Jan-Luuk
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Pasch, Andreas
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Bakker, Stephan
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van Goor, Harry
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van den Born, Joost
e63de1d7-c2a5-403f-86d0-62d76ee20aa1
Koning, Anne M.
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Frenay, Anne-Roos
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Bachtler, Matthias
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Riphagen, Ineke
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Minovic, Isidor
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Feelisch, Martin
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Dekker, Marinda
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Bulthuis, Marian
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Gansevoort, Ron
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Hillebrands, Jan-Luuk
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Pasch, Andreas
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Bakker, Stephan
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van Goor, Harry
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van den Born, Joost, Koning, Anne M., Frenay, Anne-Roos, Bachtler, Matthias, Riphagen, Ineke, Minovic, Isidor, Feelisch, Martin, Dekker, Marinda, Bulthuis, Marian, Gansevoort, Ron, Hillebrands, Jan-Luuk, Pasch, Andreas, Bakker, Stephan and van Goor, Harry (2019) Urinary excretion of sulfur metabolites and risk of cardiovascular events and all-cause mortality in the general population. Antioxidants & Redox Signaling, 30 (17), 1999-2010. (doi:10.1089/ars.2017.7040).

Record type: Article

Abstract

Thiosulfate and sulfate are natural dietary constituents, as well as oxidative metabolites of hydrogen sulfide (H2S), a gaseous signaling molecule with cardiovascular protective properties. Urinary thiosulfate and sulfate excretion are associated with favorable disease outcome in high-risk patients. In our large, general population based cohort neither thiosulfate, nor sulfate excretion is associated with risk of cardiovascular events. However, sulfate, but not thiosulfate, excretion, is inversely associated with risk of all-cause mortality. This strong association leads to the hypothesis that urinary sulfate excretion is a clinically relevant biomarker of physiological disturbance and may even serve as a target for nutritional intervention to promote healthy aging.

Text
2018 van_den_Born Antiox Redox Signal-in press - Accepted Manuscript
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More information

Accepted/In Press date: 10 June 2018
e-pub ahead of print date: 25 June 2018
Published date: 23 April 2019
Keywords: Journal Article

Identifiers

Local EPrints ID: 424813
URI: https://eprints.soton.ac.uk/id/eprint/424813
ISSN: 1523-0864
PURE UUID: 0a5675bc-1ee9-4e96-ac0b-e1e210f4bff1
ORCID for Martin Feelisch: ORCID iD orcid.org/0000-0003-2320-1158

Catalogue record

Date deposited: 05 Oct 2018 11:47
Last modified: 03 Dec 2019 05:17

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Contributors

Author: Joost van den Born
Author: Anne M. Koning
Author: Anne-Roos Frenay
Author: Matthias Bachtler
Author: Ineke Riphagen
Author: Isidor Minovic
Author: Martin Feelisch ORCID iD
Author: Marinda Dekker
Author: Marian Bulthuis
Author: Ron Gansevoort
Author: Jan-Luuk Hillebrands
Author: Andreas Pasch
Author: Stephan Bakker
Author: Harry van Goor

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