Urinary excretion of sulfur metabolites and risk of cardiovascular events and all-cause mortality in the general population
Urinary excretion of sulfur metabolites and risk of cardiovascular events and all-cause mortality in the general population
Thiosulfate and sulfate are natural dietary constituents, as well as oxidative metabolites of hydrogen sulfide (H2S), a gaseous signaling molecule with cardiovascular protective properties. Urinary thiosulfate and sulfate excretion are associated with favorable disease outcome in high-risk patients. In our large, general population based cohort neither thiosulfate, nor sulfate excretion is associated with risk of cardiovascular events. However, sulfate, but not thiosulfate, excretion, is inversely associated with risk of all-cause mortality. This strong association leads to the hypothesis that urinary sulfate excretion is a clinically relevant biomarker of physiological disturbance and may even serve as a target for nutritional intervention to promote healthy aging.
Journal Article
1999-2010
van den Born, Joost
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Koning, Anne M.
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Frenay, Anne-Roos
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Bachtler, Matthias
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Riphagen, Ineke
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Minovic, Isidor
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Feelisch, Martin
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Dekker, Marinda
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Bulthuis, Marian
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Gansevoort, Ron
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Hillebrands, Jan-Luuk
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Pasch, Andreas
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Bakker, Stephan
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van Goor, Harry
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23 April 2019
van den Born, Joost
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Koning, Anne M.
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Frenay, Anne-Roos
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Bachtler, Matthias
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Riphagen, Ineke
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Minovic, Isidor
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Feelisch, Martin
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Dekker, Marinda
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Bulthuis, Marian
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Gansevoort, Ron
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Hillebrands, Jan-Luuk
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Pasch, Andreas
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Bakker, Stephan
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van Goor, Harry
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van den Born, Joost, Koning, Anne M., Frenay, Anne-Roos, Bachtler, Matthias, Riphagen, Ineke, Minovic, Isidor, Feelisch, Martin, Dekker, Marinda, Bulthuis, Marian, Gansevoort, Ron, Hillebrands, Jan-Luuk, Pasch, Andreas, Bakker, Stephan and van Goor, Harry
(2019)
Urinary excretion of sulfur metabolites and risk of cardiovascular events and all-cause mortality in the general population.
Antioxidants & Redox Signaling, 30 (17), .
(doi:10.1089/ars.2017.7040).
Abstract
Thiosulfate and sulfate are natural dietary constituents, as well as oxidative metabolites of hydrogen sulfide (H2S), a gaseous signaling molecule with cardiovascular protective properties. Urinary thiosulfate and sulfate excretion are associated with favorable disease outcome in high-risk patients. In our large, general population based cohort neither thiosulfate, nor sulfate excretion is associated with risk of cardiovascular events. However, sulfate, but not thiosulfate, excretion, is inversely associated with risk of all-cause mortality. This strong association leads to the hypothesis that urinary sulfate excretion is a clinically relevant biomarker of physiological disturbance and may even serve as a target for nutritional intervention to promote healthy aging.
Text
2018 van_den_Born Antiox Redox Signal-in press
- Accepted Manuscript
More information
Accepted/In Press date: 10 June 2018
e-pub ahead of print date: 25 June 2018
Published date: 23 April 2019
Keywords:
Journal Article
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Local EPrints ID: 424813
URI: http://eprints.soton.ac.uk/id/eprint/424813
ISSN: 1523-0864
PURE UUID: 0a5675bc-1ee9-4e96-ac0b-e1e210f4bff1
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Date deposited: 05 Oct 2018 11:47
Last modified: 16 Mar 2024 06:54
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Contributors
Author:
Joost van den Born
Author:
Anne M. Koning
Author:
Anne-Roos Frenay
Author:
Matthias Bachtler
Author:
Ineke Riphagen
Author:
Isidor Minovic
Author:
Marinda Dekker
Author:
Marian Bulthuis
Author:
Ron Gansevoort
Author:
Jan-Luuk Hillebrands
Author:
Andreas Pasch
Author:
Stephan Bakker
Author:
Harry van Goor
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