Defective NOTCH signaling drives increased vascular smooth muscle cell apoptosis and contractile differentiation in bicuspid aortic valve aortopathy: a review of the evidence and future directions
Defective NOTCH signaling drives increased vascular smooth muscle cell apoptosis and contractile differentiation in bicuspid aortic valve aortopathy: a review of the evidence and future directions
Bicuspid aortic valve (BAV) disease remains the most common congenital cardiac disease and is associated with an increased risk of potentially fatal aortopathy including aortic aneurysm and dissection. Mutations in the NOTCH1 gene are one of only a few genetic anomalies identified in BAV disease; however evidence for defective NOTCH signaling, and its involvement in the characteristic histological changes of VSMC apoptosis and differentiation in ascending aortae of BAV patients is lacking. This review scrutinizes the evidence for the interactions of NOTCH signaling, cellular differentiation and apoptosis in the context of aortic VSMCs and provides focus for future research efforts in the diagnosis of BAV aortopathy and prevention of catastrophic complications through NOTCH signaling manipulation.
61-68
Harrison, O.J.
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Visan, A.C.
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Moorjani, N.
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Modi, A.
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Salhiyyah, K.
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Torrens, C.
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Ohri, S.K.
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Cagampang, F.R.
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1 February 2019
Harrison, O.J.
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Visan, A.C.
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Moorjani, N.
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Modi, A.
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Salhiyyah, K.
63ac0bb3-5b7d-4d9f-87e5-3a20ba738a6a
Torrens, C.
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Ohri, S.K.
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Cagampang, F.R.
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Harrison, O.J., Visan, A.C., Moorjani, N., Modi, A., Salhiyyah, K., Torrens, C., Ohri, S.K. and Cagampang, F.R.
(2019)
Defective NOTCH signaling drives increased vascular smooth muscle cell apoptosis and contractile differentiation in bicuspid aortic valve aortopathy: a review of the evidence and future directions.
Trends in Cardiovascular Medicine, 29 (2), .
(doi:10.1016/j.tcm.2018.06.008).
Abstract
Bicuspid aortic valve (BAV) disease remains the most common congenital cardiac disease and is associated with an increased risk of potentially fatal aortopathy including aortic aneurysm and dissection. Mutations in the NOTCH1 gene are one of only a few genetic anomalies identified in BAV disease; however evidence for defective NOTCH signaling, and its involvement in the characteristic histological changes of VSMC apoptosis and differentiation in ascending aortae of BAV patients is lacking. This review scrutinizes the evidence for the interactions of NOTCH signaling, cellular differentiation and apoptosis in the context of aortic VSMCs and provides focus for future research efforts in the diagnosis of BAV aortopathy and prevention of catastrophic complications through NOTCH signaling manipulation.
Text
BAV review TCM
- Accepted Manuscript
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2019 (65) Trends in Cardiovascular Medicine (NOTCH signalling in BAV)
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Accepted/In Press date: 8 June 2018
e-pub ahead of print date: 21 June 2018
Published date: 1 February 2019
Identifiers
Local EPrints ID: 424827
URI: http://eprints.soton.ac.uk/id/eprint/424827
ISSN: 1050-1738
PURE UUID: e3add679-1406-4114-ba6e-8625682d9341
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Date deposited: 05 Oct 2018 11:48
Last modified: 16 Mar 2024 06:52
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Contributors
Author:
O.J. Harrison
Author:
A.C. Visan
Author:
N. Moorjani
Author:
A. Modi
Author:
K. Salhiyyah
Author:
C. Torrens
Author:
S.K. Ohri
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