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Profiling biomarkers of traumatic axonal injury: from mouse to man

Profiling biomarkers of traumatic axonal injury: from mouse to man
Profiling biomarkers of traumatic axonal injury: from mouse to man

Traumatic brain injury (TBI) poses a major public health problem on a global scale. Its burden results from high mortality and significant morbidity in survivors. This stems, in part, from an ongoing inadequacy in diagnostic and prognostic indicators despite significant technological advances. Traumatic axonal injury (TAI) is a key driver of the ongoing pathological process following TBI, causing chronic neurological deficits and disability. The science underpinning biomarkers of TAI has been a subject of many reviews in recent literature. However, in this review we provide a comprehensive account of biomarkers from animal models to clinical studies, bridging the gap between experimental science and clinical medicine. We have discussed pathogenesis, temporal kinetics, relationships to neuro-imaging, and, most importantly, clinical applicability in order to provide a holistic perspective of how this could improve TBI diagnosis and predict clinical outcome in a real-life setting. We conclude that early and reliable identification of axonal injury post-TBI with the help of body fluid biomarkers could enhance current care of TBI patients by (i) increasing speed and accuracy of diagnosis, (ii) providing invaluable prognostic information, (iii) allow efficient allocation of rehabilitation services, and (iv) provide potential therapeutic targets. The optimal model for assessing TAI is likely to involve multiple components, including several blood biomarkers and neuro-imaging modalities, at different time points.

Amyloid, Biomarkers, Myelin basic protein, Neurofilaments, Spectrin breakdown products, Tau, Traumatic axonal injury, Traumatic brain injury
0303-8467
6-20
Manivannan, Susruta
aa3eed1f-298f-4749-9afc-c6f979e0da87
Makwana, Milan
4b894402-3dd3-47c2-a304-27589b856c02
Ahmed, Aminul Islam
175a1358-5255-4f20-8cf9-96fac237bc9f
Zaben, Malik
cde8ed3c-f512-43f6-8ead-4eb0c8e33c77
Manivannan, Susruta
aa3eed1f-298f-4749-9afc-c6f979e0da87
Makwana, Milan
4b894402-3dd3-47c2-a304-27589b856c02
Ahmed, Aminul Islam
175a1358-5255-4f20-8cf9-96fac237bc9f
Zaben, Malik
cde8ed3c-f512-43f6-8ead-4eb0c8e33c77

Manivannan, Susruta, Makwana, Milan, Ahmed, Aminul Islam and Zaben, Malik (2018) Profiling biomarkers of traumatic axonal injury: from mouse to man. Clinical Neurology and Neurosurgery, 171, 6-20. (doi:10.1016/j.clineuro.2018.05.017).

Record type: Review

Abstract

Traumatic brain injury (TBI) poses a major public health problem on a global scale. Its burden results from high mortality and significant morbidity in survivors. This stems, in part, from an ongoing inadequacy in diagnostic and prognostic indicators despite significant technological advances. Traumatic axonal injury (TAI) is a key driver of the ongoing pathological process following TBI, causing chronic neurological deficits and disability. The science underpinning biomarkers of TAI has been a subject of many reviews in recent literature. However, in this review we provide a comprehensive account of biomarkers from animal models to clinical studies, bridging the gap between experimental science and clinical medicine. We have discussed pathogenesis, temporal kinetics, relationships to neuro-imaging, and, most importantly, clinical applicability in order to provide a holistic perspective of how this could improve TBI diagnosis and predict clinical outcome in a real-life setting. We conclude that early and reliable identification of axonal injury post-TBI with the help of body fluid biomarkers could enhance current care of TBI patients by (i) increasing speed and accuracy of diagnosis, (ii) providing invaluable prognostic information, (iii) allow efficient allocation of rehabilitation services, and (iv) provide potential therapeutic targets. The optimal model for assessing TAI is likely to involve multiple components, including several blood biomarkers and neuro-imaging modalities, at different time points.

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More information

Accepted/In Press date: 14 May 2018
e-pub ahead of print date: 18 May 2018
Published date: 1 August 2018
Keywords: Amyloid, Biomarkers, Myelin basic protein, Neurofilaments, Spectrin breakdown products, Tau, Traumatic axonal injury, Traumatic brain injury

Identifiers

Local EPrints ID: 424866
URI: http://eprints.soton.ac.uk/id/eprint/424866
ISSN: 0303-8467
PURE UUID: 511abb37-3314-4e0e-982b-5ab7acb5e64d

Catalogue record

Date deposited: 05 Oct 2018 11:51
Last modified: 07 Oct 2020 00:56

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Contributors

Author: Susruta Manivannan
Author: Milan Makwana
Author: Aminul Islam Ahmed
Author: Malik Zaben

University divisions

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