The role of mineralocorticoid receptor antagonists in patients with acute myocardial infarction: Is the evidence reflective of modern clinical practice?
The role of mineralocorticoid receptor antagonists in patients with acute myocardial infarction: Is the evidence reflective of modern clinical practice?
Highlights
• The incidence of ischemic heart failure has diminished with the adoption of percutaneous coronary intervention.
• The landmark EPHESUS study established eplerenone in the management of patients with acute myocardial infarction and a left ventricular ejection fraction <40%.
• The applicability of EPHESUS and therefore eplerenone in the current era of interventional cardiology is controversial.
Animals, Clinical Trials as Topic, Eplerenone/adverse effects, Evidence-Based Medicine, Humans, Mineralocorticoid Receptor Antagonists/adverse effects, Myocardial Infarction/diagnosis, Percutaneous Coronary Intervention/adverse effects, Recovery of Function, Risk Factors, Stroke Volume/drug effects, Treatment Outcome, Ventricular Dysfunction, Left/diagnosis, Ventricular Function, Left/drug effects
452-456
Hinton, Jonathan
3d2fa767-e092-41d8-a4e4-2858c84192c1
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Myat, Aung
cf15770a-c78b-4919-9cb5-db128227e535
Curzen, Nick
70f3ea49-51b1-418f-8e56-8210aef1abf4
June 2018
Hinton, Jonathan
3d2fa767-e092-41d8-a4e4-2858c84192c1
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Myat, Aung
cf15770a-c78b-4919-9cb5-db128227e535
Curzen, Nick
70f3ea49-51b1-418f-8e56-8210aef1abf4
Hinton, Jonathan, Mahmoudi, Michael, Myat, Aung and Curzen, Nick
(2018)
The role of mineralocorticoid receptor antagonists in patients with acute myocardial infarction: Is the evidence reflective of modern clinical practice?
Cardiovascular Revascularization Medicine, 19 (4), .
(doi:10.1016/j.carrev.2018.04.012).
Abstract
Highlights
• The incidence of ischemic heart failure has diminished with the adoption of percutaneous coronary intervention.
• The landmark EPHESUS study established eplerenone in the management of patients with acute myocardial infarction and a left ventricular ejection fraction <40%.
• The applicability of EPHESUS and therefore eplerenone in the current era of interventional cardiology is controversial.
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More information
Accepted/In Press date: 10 April 2018
e-pub ahead of print date: 17 April 2018
Published date: June 2018
Keywords:
Animals, Clinical Trials as Topic, Eplerenone/adverse effects, Evidence-Based Medicine, Humans, Mineralocorticoid Receptor Antagonists/adverse effects, Myocardial Infarction/diagnosis, Percutaneous Coronary Intervention/adverse effects, Recovery of Function, Risk Factors, Stroke Volume/drug effects, Treatment Outcome, Ventricular Dysfunction, Left/diagnosis, Ventricular Function, Left/drug effects
Identifiers
Local EPrints ID: 424879
URI: http://eprints.soton.ac.uk/id/eprint/424879
ISSN: 1553-8389
PURE UUID: 6688f8f2-e6dc-4382-82df-749465146337
Catalogue record
Date deposited: 05 Oct 2018 11:52
Last modified: 16 Mar 2024 04:24
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Contributors
Author:
Jonathan Hinton
Author:
Aung Myat
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