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The role of mineralocorticoid receptor antagonists in patients with acute myocardial infarction: Is the evidence reflective of modern clinical practice?

The role of mineralocorticoid receptor antagonists in patients with acute myocardial infarction: Is the evidence reflective of modern clinical practice?
The role of mineralocorticoid receptor antagonists in patients with acute myocardial infarction: Is the evidence reflective of modern clinical practice?
Highlights • The incidence of ischemic heart failure has diminished with the adoption of percutaneous coronary intervention. • The landmark EPHESUS study established eplerenone in the management of patients with acute myocardial infarction and a left ventricular ejection fraction <40%. • The applicability of EPHESUS and therefore eplerenone in the current era of interventional cardiology is controversial.
Animals, Clinical Trials as Topic, Eplerenone/adverse effects, Evidence-Based Medicine, Humans, Mineralocorticoid Receptor Antagonists/adverse effects, Myocardial Infarction/diagnosis, Percutaneous Coronary Intervention/adverse effects, Recovery of Function, Risk Factors, Stroke Volume/drug effects, Treatment Outcome, Ventricular Dysfunction, Left/diagnosis, Ventricular Function, Left/drug effects
1553-8389
452-456
Hinton, Jonathan
3d2fa767-e092-41d8-a4e4-2858c84192c1
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Myat, Aung
cf15770a-c78b-4919-9cb5-db128227e535
Curzen, Nick
70f3ea49-51b1-418f-8e56-8210aef1abf4
Hinton, Jonathan
3d2fa767-e092-41d8-a4e4-2858c84192c1
Mahmoudi, Michael
f6a55246-399e-4f81-944e-a4b169786e8a
Myat, Aung
cf15770a-c78b-4919-9cb5-db128227e535
Curzen, Nick
70f3ea49-51b1-418f-8e56-8210aef1abf4

Hinton, Jonathan, Mahmoudi, Michael, Myat, Aung and Curzen, Nick (2018) The role of mineralocorticoid receptor antagonists in patients with acute myocardial infarction: Is the evidence reflective of modern clinical practice? Cardiovascular Revascularization Medicine, 19 (4), 452-456. (doi:10.1016/j.carrev.2018.04.012).

Record type: Article

Abstract

Highlights • The incidence of ischemic heart failure has diminished with the adoption of percutaneous coronary intervention. • The landmark EPHESUS study established eplerenone in the management of patients with acute myocardial infarction and a left ventricular ejection fraction <40%. • The applicability of EPHESUS and therefore eplerenone in the current era of interventional cardiology is controversial.

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More information

Accepted/In Press date: 10 April 2018
e-pub ahead of print date: 17 April 2018
Published date: June 2018
Keywords: Animals, Clinical Trials as Topic, Eplerenone/adverse effects, Evidence-Based Medicine, Humans, Mineralocorticoid Receptor Antagonists/adverse effects, Myocardial Infarction/diagnosis, Percutaneous Coronary Intervention/adverse effects, Recovery of Function, Risk Factors, Stroke Volume/drug effects, Treatment Outcome, Ventricular Dysfunction, Left/diagnosis, Ventricular Function, Left/drug effects

Identifiers

Local EPrints ID: 424879
URI: http://eprints.soton.ac.uk/id/eprint/424879
ISSN: 1553-8389
PURE UUID: 6688f8f2-e6dc-4382-82df-749465146337
ORCID for Michael Mahmoudi: ORCID iD orcid.org/0000-0003-1293-8461
ORCID for Nick Curzen: ORCID iD orcid.org/0000-0001-9651-7829

Catalogue record

Date deposited: 05 Oct 2018 11:52
Last modified: 16 Mar 2024 04:24

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Contributors

Author: Jonathan Hinton
Author: Aung Myat
Author: Nick Curzen ORCID iD

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