The University of Southampton
University of Southampton Institutional Repository

Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology

Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology
Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

0143-5221
851-868
Horsburgh, Karen
1bba1a89-7a12-471f-b229-c3633e1a1a57
Wardlaw, Joanna M.
8e7202ad-0fd9-430c-b26a-05b1106ecaad
van Agtmael, Tom
82ad1f75-4a91-41d2-93e3-dd5eaaed7479
Allan, Stuart M.
33a19692-e2a8-438b-b9be-a2e832f42f98
Ashford, Mike L.J.
c6e52a62-ca23-4be1-9d17-09b9ce881849
Bath, Philip M.
54a69306-85be-480a-b137-584b42cf64a1
Brown, Rosalind
bc4788ed-313e-43ca-8d31-a58b0b899fe1
Berwick, Jason
ddca0801-73e6-41f3-b21e-5006f9f17c42
Cader, M. Zameel
61b6fde4-b9db-4481-9c16-96133f80dd56
Carare, Roxana O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Davis, John B.
79b18193-3c79-4688-a6da-fa1c3b0d9927
Duncombe, Jessica
a0115fd3-064d-486c-8173-c74320c6d321
Farr, Tracy D.
278245a3-077f-4b48-bca2-abfe2202b1d5
Fowler, Jill H.
afa24905-5fb7-4c46-bd10-a7e0e60fe63e
Goense, Jozien
1de5ecee-9896-4ccb-8a88-6e6e28d97eea
Granata, Alessandra
d145b953-93b7-4188-a103-3993857e37ce
Hall, Catherine N.
9bc31254-8cda-4ae8-98e2-3a2ef22c70d4
Hainsworth, Atticus H.
221ee2c3-0802-46a2-9da2-07a4b6e3e7b2
Harvey, Adam
3072f2af-46aa-4c69-90a1-01e384fcec5b
Hawkes, Cheryl A.
031a17ac-0931-4ff9-93cc-df8cb58e14f7
Joutel, Anne
a105f6e5-c90e-4014-a258-3cc9d830348f
Kalaria, Rajesh N.
234141f1-080d-42b0-86c1-51b163ee16f8
Kehoe, Patrick G.
c3d54052-f508-4091-86ce-ec4727ef3c9a
Lawrence, Catherine B.
8c1ddc90-46fe-4a87-a9c7-6f88010b6c20
Lockhart, Andy
b4ee0657-3348-453f-a62e-144829043708
Love, Seth
c8c00a86-ecf8-4f61-8377-254305bdbc02
Macleod, Malcolm R.
fc01b576-d427-4c06-b7c0-dd872522fa88
Macrae, I. Mhairi
77656d7b-b2df-48b1-8536-5895319ac316
Markus, Hugh S.
d21f16b9-a4ba-4960-b52a-37a432191de4
McCabe, Chris
00e209b8-1190-410d-b254-5f4d9cb050d2
McColl, Barry W.
97408fc1-8a9e-45e6-b93e-d99ce77d7642
Meakin, Paul J.
e93d6082-c12a-47c9-8505-a690f5d15df7
Miller, Alyson
2c519e65-49d5-4131-ab3b-7affb0fe0be4
Nedergaard, Maiken
36f41c7b-2eea-49c5-8136-bdf27a344514
O'Sullivan, Michael
a100f402-63c5-4fe7-b817-fc1c9da31097
Quinn, Terry J.
5fefb481-f593-4292-9158-e341776045fa
Rajani, Rikesh
be0a60c2-3c53-43a0-ba7b-943a783f3b99
Saksida, Lisa M.
5e48cbc8-2dc8-4de7-bfa3-6eb42fb1096a
Smith, Colin
d991039c-1c8b-4aff-a306-b45c67c486e9
Smith, Kenneth J.
2722c4bd-8969-4277-a8e3-bd936356d95e
Touyz, Rhian M.
15bebb12-0fac-448c-be73-2d67e2658f98
Trueman, Rebecca C.
0b9c6154-5eba-4cea-8b85-728943f99820
Wang, Tao
91dfd769-44ab-4f2f-a68b-0bd8b317bf09
Williams, Anna
8363c441-2531-42b9-954d-775a7527f973
Williams, Steven C.R.
23e3241c-ffb6-4c38-80ed-7ba8ecd5f005
Work, Lorraine M.
1e939e95-c7b5-4360-a39c-df0ceb019749
Horsburgh, Karen
1bba1a89-7a12-471f-b229-c3633e1a1a57
Wardlaw, Joanna M.
8e7202ad-0fd9-430c-b26a-05b1106ecaad
van Agtmael, Tom
82ad1f75-4a91-41d2-93e3-dd5eaaed7479
Allan, Stuart M.
33a19692-e2a8-438b-b9be-a2e832f42f98
Ashford, Mike L.J.
c6e52a62-ca23-4be1-9d17-09b9ce881849
Bath, Philip M.
54a69306-85be-480a-b137-584b42cf64a1
Brown, Rosalind
bc4788ed-313e-43ca-8d31-a58b0b899fe1
Berwick, Jason
ddca0801-73e6-41f3-b21e-5006f9f17c42
Cader, M. Zameel
61b6fde4-b9db-4481-9c16-96133f80dd56
Carare, Roxana O.
0478c197-b0c1-4206-acae-54e88c8f21fa
Davis, John B.
79b18193-3c79-4688-a6da-fa1c3b0d9927
Duncombe, Jessica
a0115fd3-064d-486c-8173-c74320c6d321
Farr, Tracy D.
278245a3-077f-4b48-bca2-abfe2202b1d5
Fowler, Jill H.
afa24905-5fb7-4c46-bd10-a7e0e60fe63e
Goense, Jozien
1de5ecee-9896-4ccb-8a88-6e6e28d97eea
Granata, Alessandra
d145b953-93b7-4188-a103-3993857e37ce
Hall, Catherine N.
9bc31254-8cda-4ae8-98e2-3a2ef22c70d4
Hainsworth, Atticus H.
221ee2c3-0802-46a2-9da2-07a4b6e3e7b2
Harvey, Adam
3072f2af-46aa-4c69-90a1-01e384fcec5b
Hawkes, Cheryl A.
031a17ac-0931-4ff9-93cc-df8cb58e14f7
Joutel, Anne
a105f6e5-c90e-4014-a258-3cc9d830348f
Kalaria, Rajesh N.
234141f1-080d-42b0-86c1-51b163ee16f8
Kehoe, Patrick G.
c3d54052-f508-4091-86ce-ec4727ef3c9a
Lawrence, Catherine B.
8c1ddc90-46fe-4a87-a9c7-6f88010b6c20
Lockhart, Andy
b4ee0657-3348-453f-a62e-144829043708
Love, Seth
c8c00a86-ecf8-4f61-8377-254305bdbc02
Macleod, Malcolm R.
fc01b576-d427-4c06-b7c0-dd872522fa88
Macrae, I. Mhairi
77656d7b-b2df-48b1-8536-5895319ac316
Markus, Hugh S.
d21f16b9-a4ba-4960-b52a-37a432191de4
McCabe, Chris
00e209b8-1190-410d-b254-5f4d9cb050d2
McColl, Barry W.
97408fc1-8a9e-45e6-b93e-d99ce77d7642
Meakin, Paul J.
e93d6082-c12a-47c9-8505-a690f5d15df7
Miller, Alyson
2c519e65-49d5-4131-ab3b-7affb0fe0be4
Nedergaard, Maiken
36f41c7b-2eea-49c5-8136-bdf27a344514
O'Sullivan, Michael
a100f402-63c5-4fe7-b817-fc1c9da31097
Quinn, Terry J.
5fefb481-f593-4292-9158-e341776045fa
Rajani, Rikesh
be0a60c2-3c53-43a0-ba7b-943a783f3b99
Saksida, Lisa M.
5e48cbc8-2dc8-4de7-bfa3-6eb42fb1096a
Smith, Colin
d991039c-1c8b-4aff-a306-b45c67c486e9
Smith, Kenneth J.
2722c4bd-8969-4277-a8e3-bd936356d95e
Touyz, Rhian M.
15bebb12-0fac-448c-be73-2d67e2658f98
Trueman, Rebecca C.
0b9c6154-5eba-4cea-8b85-728943f99820
Wang, Tao
91dfd769-44ab-4f2f-a68b-0bd8b317bf09
Williams, Anna
8363c441-2531-42b9-954d-775a7527f973
Williams, Steven C.R.
23e3241c-ffb6-4c38-80ed-7ba8ecd5f005
Work, Lorraine M.
1e939e95-c7b5-4360-a39c-df0ceb019749

Horsburgh, Karen, Wardlaw, Joanna M., van Agtmael, Tom, Allan, Stuart M., Ashford, Mike L.J., Bath, Philip M., Brown, Rosalind, Berwick, Jason, Cader, M. Zameel, Carare, Roxana O., Davis, John B., Duncombe, Jessica, Farr, Tracy D., Fowler, Jill H., Goense, Jozien, Granata, Alessandra, Hall, Catherine N., Hainsworth, Atticus H., Harvey, Adam, Hawkes, Cheryl A., Joutel, Anne, Kalaria, Rajesh N., Kehoe, Patrick G., Lawrence, Catherine B., Lockhart, Andy, Love, Seth, Macleod, Malcolm R., Macrae, I. Mhairi, Markus, Hugh S., McCabe, Chris, McColl, Barry W., Meakin, Paul J., Miller, Alyson, Nedergaard, Maiken, O'Sullivan, Michael, Quinn, Terry J., Rajani, Rikesh, Saksida, Lisa M., Smith, Colin, Smith, Kenneth J., Touyz, Rhian M., Trueman, Rebecca C., Wang, Tao, Williams, Anna, Williams, Steven C.R. and Work, Lorraine M. (2018) Small vessels, dementia and chronic diseases: molecular mechanisms and pathophysiology. Clinical Science, 132 (8), 851-868. (doi:10.1042/CS20171620).

Record type: Article

Abstract

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

Full text not available from this repository.

More information

Accepted/In Press date: 21 February 2018
e-pub ahead of print date: 30 April 2018

Identifiers

Local EPrints ID: 424880
URI: http://eprints.soton.ac.uk/id/eprint/424880
ISSN: 0143-5221
PURE UUID: bd2bdcec-80fc-4d8e-ae3b-bd4302f73f4e

Catalogue record

Date deposited: 05 Oct 2018 11:52
Last modified: 07 Oct 2020 00:27

Export record

Altmetrics

Contributors

Author: Karen Horsburgh
Author: Joanna M. Wardlaw
Author: Tom van Agtmael
Author: Stuart M. Allan
Author: Mike L.J. Ashford
Author: Philip M. Bath
Author: Rosalind Brown
Author: Jason Berwick
Author: M. Zameel Cader
Author: John B. Davis
Author: Jessica Duncombe
Author: Tracy D. Farr
Author: Jill H. Fowler
Author: Jozien Goense
Author: Alessandra Granata
Author: Catherine N. Hall
Author: Atticus H. Hainsworth
Author: Adam Harvey
Author: Cheryl A. Hawkes
Author: Anne Joutel
Author: Rajesh N. Kalaria
Author: Patrick G. Kehoe
Author: Catherine B. Lawrence
Author: Andy Lockhart
Author: Seth Love
Author: Malcolm R. Macleod
Author: I. Mhairi Macrae
Author: Hugh S. Markus
Author: Chris McCabe
Author: Barry W. McColl
Author: Paul J. Meakin
Author: Alyson Miller
Author: Maiken Nedergaard
Author: Michael O'Sullivan
Author: Terry J. Quinn
Author: Rikesh Rajani
Author: Lisa M. Saksida
Author: Colin Smith
Author: Kenneth J. Smith
Author: Rhian M. Touyz
Author: Rebecca C. Trueman
Author: Tao Wang
Author: Anna Williams
Author: Steven C.R. Williams
Author: Lorraine M. Work

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×