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Intestinal fatty acid binding protein as a marker of necrosis and severity in acute pancreatitis

Intestinal fatty acid binding protein as a marker of necrosis and severity in acute pancreatitis
Intestinal fatty acid binding protein as a marker of necrosis and severity in acute pancreatitis

Objectives The aim of this study was to study intestinal fatty acid binding protein (i-FABP) as a potential biomarker in predicting severity of acute pancreatitis (AP). Methods In a prospective multicenter cohort study, plasma levels of i-FABP were measured in 402 patients with AP. Severity of AP was determined based on the 1992 Atlanta Classification. Results Admission levels of plasma i-FABP were significantly higher in patients with pancreatic necrosis, in patients having systemic complications, in patients treated invasively, in patients treated in the intensive care unit, in patients with severe AP, and in deceased patients. Plasma i-FABP levels on admission yielded an area under curve (AUC) of 0.732 in discriminating patients with or without pancreatic necrosis and AUC of 0.669 in predicting severe AP. Combination of levels of i-FABP and venous lactate on the day of admission showed higher discriminative power in severe AP - AUC of 0.808. Conclusions Higher i-FABP levels on admission were associated with pancreatic necrosis, systemic complications, and severe AP. Low levels of i-FABP had a high negative predictive value for pancreatic necrosis and severe AP. Combination of levels of i-FABP and venous lactates on admission were superior to either of markers used alone in predicting severe AP.

acute pancreatitis, i-FABP, intestinal permeability, prognosis
0885-3177
715-720
Kupčinskas, Juozas
3decb637-58ea-4c91-bc57-0fead3bb9475
Gedgaudas, Rolandas
d3e3d35d-68d0-47d0-b7ec-d78578521df5
Hartman, Hannes
d796ce8e-684a-4768-8e30-a0e740520ab3
Sippola, Tomi
10dc1a38-9ad3-47db-b93d-0c9ba85a905a
Lindström, Outi
7651f503-48e2-49f6-b95b-4d8cb6883afe
Johnson, Colin D.
e50aa9cd-8c61-4fe3-a0b3-f51cc3a6c74a
Regnér, Sara
5a54bcfa-8afa-42af-8125-f407f66b61b2
Kupčinskas, Juozas
3decb637-58ea-4c91-bc57-0fead3bb9475
Gedgaudas, Rolandas
d3e3d35d-68d0-47d0-b7ec-d78578521df5
Hartman, Hannes
d796ce8e-684a-4768-8e30-a0e740520ab3
Sippola, Tomi
10dc1a38-9ad3-47db-b93d-0c9ba85a905a
Lindström, Outi
7651f503-48e2-49f6-b95b-4d8cb6883afe
Johnson, Colin D.
e50aa9cd-8c61-4fe3-a0b3-f51cc3a6c74a
Regnér, Sara
5a54bcfa-8afa-42af-8125-f407f66b61b2

Kupčinskas, Juozas, Gedgaudas, Rolandas, Hartman, Hannes, Sippola, Tomi, Lindström, Outi, Johnson, Colin D. and Regnér, Sara (2018) Intestinal fatty acid binding protein as a marker of necrosis and severity in acute pancreatitis. Pancreas, 47 (6), 715-720. (doi:10.1097/MPA.0000000000001068).

Record type: Article

Abstract

Objectives The aim of this study was to study intestinal fatty acid binding protein (i-FABP) as a potential biomarker in predicting severity of acute pancreatitis (AP). Methods In a prospective multicenter cohort study, plasma levels of i-FABP were measured in 402 patients with AP. Severity of AP was determined based on the 1992 Atlanta Classification. Results Admission levels of plasma i-FABP were significantly higher in patients with pancreatic necrosis, in patients having systemic complications, in patients treated invasively, in patients treated in the intensive care unit, in patients with severe AP, and in deceased patients. Plasma i-FABP levels on admission yielded an area under curve (AUC) of 0.732 in discriminating patients with or without pancreatic necrosis and AUC of 0.669 in predicting severe AP. Combination of levels of i-FABP and venous lactate on the day of admission showed higher discriminative power in severe AP - AUC of 0.808. Conclusions Higher i-FABP levels on admission were associated with pancreatic necrosis, systemic complications, and severe AP. Low levels of i-FABP had a high negative predictive value for pancreatic necrosis and severe AP. Combination of levels of i-FABP and venous lactates on admission were superior to either of markers used alone in predicting severe AP.

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More information

Accepted/In Press date: 11 April 2018
Published date: 1 July 2018
Keywords: acute pancreatitis, i-FABP, intestinal permeability, prognosis

Identifiers

Local EPrints ID: 424956
URI: http://eprints.soton.ac.uk/id/eprint/424956
ISSN: 0885-3177
PURE UUID: 7111eb75-0ce6-4b71-a82e-ed3767c41526

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Date deposited: 05 Oct 2018 16:30
Last modified: 07 Oct 2020 00:42

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