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Probing the kinetics in supramolecular chemistry and molecular assembly by microfluidic-NMR spectroscopy

Probing the kinetics in supramolecular chemistry and molecular assembly by microfluidic-NMR spectroscopy
Probing the kinetics in supramolecular chemistry and molecular assembly by microfluidic-NMR spectroscopy

Microfluidic-NMR spectroscopy has been extended to study the kinetics in supramolecular chemistry and molecular assembly. Kinetics of a multicomponent host-guest supramolecular system containing viologen derivatives, β-cyclodextrins and cucurbit [7]urils are studied by a PMMA based microfluidic chip combined with a dedicated transmission line probe for NMR detection. By combining microfluidic technology with NMR spectroscopy, the amount of material required for a full kinetic study could be minimized. This is crucial in supramolecular chemistry, which often involves highly sophisticated and synthetically costly building blocks. The small size of the microfluidic structure is crucial in bringing the time scale for kinetic monitoring down to seconds. At the same time, the transmission line NMR probe provides sufficient sensitivity to work at low (2 mM) concentrations.

host-guest chemistry, kinetics, microfluidic-NMR, molecular assembly
1674-7291
Fang, Hongxun
a85933d0-7747-4b6b-aca5-e545e41f5d56
Sun, Yibin
e771c98f-f275-45be-bd04-eb48bc3db2ba
Wang, Xinchang
d68c3b67-d334-485f-9d7f-fd768a11442d
Sharma, Manvendra
e249236d-221d-4e59-8440-011f6863f891
Chen, Zhong
d356efdb-30c5-4a1a-af60-971fa2dfb6a9
Cao, Xiaoyu
7835d358-56da-482e-b061-c76c847a1525
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Tian, Zhongqun
1d4df9bf-8b6a-4191-bc3a-91bc107ed580
Fang, Hongxun
a85933d0-7747-4b6b-aca5-e545e41f5d56
Sun, Yibin
e771c98f-f275-45be-bd04-eb48bc3db2ba
Wang, Xinchang
d68c3b67-d334-485f-9d7f-fd768a11442d
Sharma, Manvendra
e249236d-221d-4e59-8440-011f6863f891
Chen, Zhong
d356efdb-30c5-4a1a-af60-971fa2dfb6a9
Cao, Xiaoyu
7835d358-56da-482e-b061-c76c847a1525
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Tian, Zhongqun
1d4df9bf-8b6a-4191-bc3a-91bc107ed580

Fang, Hongxun, Sun, Yibin, Wang, Xinchang, Sharma, Manvendra, Chen, Zhong, Cao, Xiaoyu, Utz, Marcel and Tian, Zhongqun (2018) Probing the kinetics in supramolecular chemistry and molecular assembly by microfluidic-NMR spectroscopy. Science China Chemistry. (doi:10.1007/s11426-018-9293-3).

Record type: Article

Abstract

Microfluidic-NMR spectroscopy has been extended to study the kinetics in supramolecular chemistry and molecular assembly. Kinetics of a multicomponent host-guest supramolecular system containing viologen derivatives, β-cyclodextrins and cucurbit [7]urils are studied by a PMMA based microfluidic chip combined with a dedicated transmission line probe for NMR detection. By combining microfluidic technology with NMR spectroscopy, the amount of material required for a full kinetic study could be minimized. This is crucial in supramolecular chemistry, which often involves highly sophisticated and synthetically costly building blocks. The small size of the microfluidic structure is crucial in bringing the time scale for kinetic monitoring down to seconds. At the same time, the transmission line NMR probe provides sufficient sensitivity to work at low (2 mM) concentrations.

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Accepted/In Press date: 24 May 2018
e-pub ahead of print date: 13 September 2018
Keywords: host-guest chemistry, kinetics, microfluidic-NMR, molecular assembly

Identifiers

Local EPrints ID: 424983
URI: http://eprints.soton.ac.uk/id/eprint/424983
ISSN: 1674-7291
PURE UUID: d621a434-1d58-4b20-8ed0-897c9b0ad872
ORCID for Marcel Utz: ORCID iD orcid.org/0000-0003-2274-9672

Catalogue record

Date deposited: 08 Oct 2018 16:30
Last modified: 22 Nov 2021 06:47

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Contributors

Author: Hongxun Fang
Author: Yibin Sun
Author: Xinchang Wang
Author: Manvendra Sharma
Author: Zhong Chen
Author: Xiaoyu Cao
Author: Marcel Utz ORCID iD
Author: Zhongqun Tian

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