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High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets

High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets
High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets
A generic approach is presented that allows high-resolution NMR spectroscopy of water/oil droplet emulsions in microfluidic devices. Microfluidic NMR spectroscopy has recently made significant advances due to the design of micro-detector systems and their successful integration with microfluidic devices. Obtaining NMR spectra of droplet suspensions, however, is complicated by the inevitable differences in magnetic susceptibility between the chip material, the continuous phase, and the droplet phases. This leads to broadening of the NMR resonance lines and results in loss of spectral resolution. We have mitigated the susceptibility difference between the continuous (oil) phase and the chip material by incorporating appropriately designed air-filled structures into the chip. The susceptibilities of the continuous and droplet (aqueous) phases have been matched by doping the droplet phase with a Eu3+ complex. Our results demonstrate that this leads to a proton line width in the droplet phase of about 3 Hz, enabling high-resolution NMR techniques.
1473-0197
3018-3024
Hale, William
08ed5dd7-febd-4a58-920a-e5cd4babe792
Rossetto, Gabriel
4efb2b09-18a0-4bba-81e8-1514c9706103
Greenhalgh, Rachel
546b4c96-b3cb-4983-b48f-8ed33248bb4e
Finch, Graeme
98b0a6bd-f2c8-4835-8960-5b9f0d462458
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b
Hale, William
08ed5dd7-febd-4a58-920a-e5cd4babe792
Rossetto, Gabriel
4efb2b09-18a0-4bba-81e8-1514c9706103
Greenhalgh, Rachel
546b4c96-b3cb-4983-b48f-8ed33248bb4e
Finch, Graeme
98b0a6bd-f2c8-4835-8960-5b9f0d462458
Utz, Marcel
c84ed64c-9e89-4051-af39-d401e423891b

Hale, William, Rossetto, Gabriel, Greenhalgh, Rachel, Finch, Graeme and Utz, Marcel (2018) High-resolution nuclear magnetic resonance spectroscopy in microfluidic droplets. Lab on a Chip, 2018 (19), 3018-3024. (doi:10.1039/C8LC00712H).

Record type: Article

Abstract

A generic approach is presented that allows high-resolution NMR spectroscopy of water/oil droplet emulsions in microfluidic devices. Microfluidic NMR spectroscopy has recently made significant advances due to the design of micro-detector systems and their successful integration with microfluidic devices. Obtaining NMR spectra of droplet suspensions, however, is complicated by the inevitable differences in magnetic susceptibility between the chip material, the continuous phase, and the droplet phases. This leads to broadening of the NMR resonance lines and results in loss of spectral resolution. We have mitigated the susceptibility difference between the continuous (oil) phase and the chip material by incorporating appropriately designed air-filled structures into the chip. The susceptibilities of the continuous and droplet (aqueous) phases have been matched by doping the droplet phase with a Eu3+ complex. Our results demonstrate that this leads to a proton line width in the droplet phase of about 3 Hz, enabling high-resolution NMR techniques.

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More information

Accepted/In Press date: 15 May 2018
e-pub ahead of print date: 22 August 2018
Published date: 7 October 2018

Identifiers

Local EPrints ID: 425040
URI: http://eprints.soton.ac.uk/id/eprint/425040
ISSN: 1473-0197
PURE UUID: c11efb99-ba27-4406-8f02-f50726507900
ORCID for Marcel Utz: ORCID iD orcid.org/0000-0003-2274-9672

Catalogue record

Date deposited: 09 Oct 2018 16:30
Last modified: 07 Oct 2020 04:47

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Contributors

Author: William Hale
Author: Gabriel Rossetto
Author: Rachel Greenhalgh
Author: Graeme Finch
Author: Marcel Utz ORCID iD

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