Primary esophagogastric neuroendocrine carcinoma: a retrospective study from the Nottingham Upper Gastrointestinal Cancer Center

Savva, Constantinos, Kaye, Philip, Soomro, Irshad, Parsons, Simon L., Eleanor, James and Madhusudan, Srinivasan (2018) Primary esophagogastric neuroendocrine carcinoma: a retrospective study from the Nottingham Upper Gastrointestinal Cancer Center. Journal of Gastrointestinal Cancer, 49 (1), 85-92. (doi:10.1007/s12029-017-0039-2).

Abstract

Primary neuroendocrine carcinomas (NECs) of the esophagus and stomach are rare with an incidence ranging from 0.01 to 0.08 cases per 100,000 persons per year [1, 2]. The prevalence of esophageal NEC ranges between 0.01 and 1.4% and gastric NEC between 2 and 3% of all gastroenteropancreatic neuroendocrine tumors [1, 3, 4, 5, 6, 7]. The esophagus is the most common site for extrapulmonary small cell carcinomas with a prevalence between 18 and 44% [6, 8, 9, 10, 11]. Pathobiology of esophagogastric NEC is largely unknown [12]. Although recent advances in diagnostic techniques have increased awareness of this rare disease, there is a lack of clinical evidence to inform appropriate management of these rare tumors [13]. In the current study, we have explored the clinicopathological characteristics, treatment modalities, and survival of 24 patients with primary esophagogastric NEC who were treated in the Nottingham University Hospitals during a 9-year period (2007–2016).

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Contributors

Author: Constantinos Savva

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