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Primary esophagogastric neuroendocrine carcinoma: a retrospective study from the Nottingham Upper Gastrointestinal Cancer Center

Primary esophagogastric neuroendocrine carcinoma: a retrospective study from the Nottingham Upper Gastrointestinal Cancer Center
Primary esophagogastric neuroendocrine carcinoma: a retrospective study from the Nottingham Upper Gastrointestinal Cancer Center
Primary neuroendocrine carcinomas (NECs) of the esophagus and stomach are rare with an incidence ranging from 0.01 to 0.08 cases per 100,000 persons per year [1, 2]. The prevalence of esophageal NEC ranges between 0.01 and 1.4% and gastric NEC between 2 and 3% of all gastroenteropancreatic neuroendocrine tumors [1, 3, 4, 5, 6, 7]. The esophagus is the most common site for extrapulmonary small cell carcinomas with a prevalence between 18 and 44% [6, 8, 9, 10, 11]. Pathobiology of esophagogastric NEC is largely unknown [12]. Although recent advances in diagnostic techniques have increased awareness of this rare disease, there is a lack of clinical evidence to inform appropriate management of these rare tumors [13]. In the current study, we have explored the clinicopathological characteristics, treatment modalities, and survival of 24 patients with primary esophagogastric NEC who were treated in the Nottingham University Hospitals during a 9-year period (2007–2016).
1941-6636
85-92
Savva, Constantinos
d6e87674-1443-41f4-84ba-81c1ccfeb3d7
Kaye, Philip
14e25ef3-49db-405e-880b-42024b354eda
Soomro, Irshad
41dc876a-3ef2-41be-8d4e-4a510fee83a6
Parsons, Simon L.
37839ff9-bdb0-4a40-b6f0-0fd79017e867
Eleanor, James
61580bdc-528d-4264-8829-5709c9ad7999
Madhusudan, Srinivasan
b09d6e47-8c8f-484f-83cf-e77c2de21952
Savva, Constantinos
d6e87674-1443-41f4-84ba-81c1ccfeb3d7
Kaye, Philip
14e25ef3-49db-405e-880b-42024b354eda
Soomro, Irshad
41dc876a-3ef2-41be-8d4e-4a510fee83a6
Parsons, Simon L.
37839ff9-bdb0-4a40-b6f0-0fd79017e867
Eleanor, James
61580bdc-528d-4264-8829-5709c9ad7999
Madhusudan, Srinivasan
b09d6e47-8c8f-484f-83cf-e77c2de21952

Savva, Constantinos, Kaye, Philip, Soomro, Irshad, Parsons, Simon L., Eleanor, James and Madhusudan, Srinivasan (2018) Primary esophagogastric neuroendocrine carcinoma: a retrospective study from the Nottingham Upper Gastrointestinal Cancer Center. Journal of Gastrointestinal Cancer, 49 (1), 85-92. (doi:10.1007/s12029-017-0039-2).

Record type: Article

Abstract

Primary neuroendocrine carcinomas (NECs) of the esophagus and stomach are rare with an incidence ranging from 0.01 to 0.08 cases per 100,000 persons per year [1, 2]. The prevalence of esophageal NEC ranges between 0.01 and 1.4% and gastric NEC between 2 and 3% of all gastroenteropancreatic neuroendocrine tumors [1, 3, 4, 5, 6, 7]. The esophagus is the most common site for extrapulmonary small cell carcinomas with a prevalence between 18 and 44% [6, 8, 9, 10, 11]. Pathobiology of esophagogastric NEC is largely unknown [12]. Although recent advances in diagnostic techniques have increased awareness of this rare disease, there is a lack of clinical evidence to inform appropriate management of these rare tumors [13]. In the current study, we have explored the clinicopathological characteristics, treatment modalities, and survival of 24 patients with primary esophagogastric NEC who were treated in the Nottingham University Hospitals during a 9-year period (2007–2016).

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e-pub ahead of print date: 11 December 2017
Published date: March 2018

Identifiers

Local EPrints ID: 425041
URI: http://eprints.soton.ac.uk/id/eprint/425041
ISSN: 1941-6636
PURE UUID: 8aa5c81b-716c-4fa2-8a7b-1d57449ca0ed
ORCID for Constantinos Savva: ORCID iD orcid.org/0000-0003-0805-4719

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Date deposited: 09 Oct 2018 16:30
Last modified: 16 Mar 2024 04:36

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Contributors

Author: Philip Kaye
Author: Irshad Soomro
Author: Simon L. Parsons
Author: James Eleanor
Author: Srinivasan Madhusudan

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