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The newly-arisen devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

The newly-arisen devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer
The newly-arisen devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer

Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian devil (Sarcophilus harrisii), a species which already harbours a more widespread contagious cancer, Devil Facial Tumour 1 (DFT1). Here we show that in contrast to DFT1, DFT2 cells express major histocompatibility complex (MHC) class I molecules, demonstrating that loss of MHC is not necessary for the emergence of a contagious cancer. However, the most highly expressed MHC class I alleles in DFT2 cells are common among host devils or non-polymorphic, reducing immunogenicity in a population sharing these alleles. In parallel, MHC class I loss is emerging in vivo, thus DFT2 may be mimicking the evolutionary trajectory of DFT1. Based on these results we propose that contagious cancers may exploit partial histocompatibility between the tumour and host, but that loss of allogeneic antigens could facilitate widespread transmission of DFT2.

2050-084X
1-18
Caldwell, Alison
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Coleby, Rachel
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Tovar, Cesar
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Stammnitz, Maximilian R.
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Mi Kwon, Young
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Owen, Rachel S.
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Tringides, Marios
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Murchison, Elizabeth P.
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Skjødt, Karsten
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Thomas, Gareth J.
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Kaufman, Jim
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Elliott, Tim
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Woods, Gregory M.
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Siddle, Hannah V.T.
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Caldwell, Alison
f431416a-765e-42a0-8516-c19c96035a2a
Coleby, Rachel
43e33db0-59b0-4c2d-93da-901bc65e08ca
Tovar, Cesar
4f690817-bccc-4123-92e7-63730ff14221
Stammnitz, Maximilian R.
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Mi Kwon, Young
adf09160-2ced-4ff7-99ed-5473ce4d6de2
Owen, Rachel S.
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Tringides, Marios
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Murchison, Elizabeth P.
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Skjødt, Karsten
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Thomas, Gareth J.
2ff54aa9-a766-416b-91ee-cf1c5be74106
Kaufman, Jim
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Elliott, Tim
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Woods, Gregory M.
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Siddle, Hannah V.T.
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Caldwell, Alison, Coleby, Rachel, Tovar, Cesar, Stammnitz, Maximilian R., Mi Kwon, Young, Owen, Rachel S., Tringides, Marios, Murchison, Elizabeth P., Skjødt, Karsten, Thomas, Gareth J., Kaufman, Jim, Elliott, Tim, Woods, Gregory M. and Siddle, Hannah V.T. (2018) The newly-arisen devil facial tumour disease 2 (DFT2) reveals a mechanism for the emergence of a contagious cancer. eLife, 7, 1-18, [e35314]. (doi:10.7554/eLife.35314).

Record type: Article

Abstract

Devil Facial Tumour 2 (DFT2) is a recently discovered contagious cancer circulating in the Tasmanian devil (Sarcophilus harrisii), a species which already harbours a more widespread contagious cancer, Devil Facial Tumour 1 (DFT1). Here we show that in contrast to DFT1, DFT2 cells express major histocompatibility complex (MHC) class I molecules, demonstrating that loss of MHC is not necessary for the emergence of a contagious cancer. However, the most highly expressed MHC class I alleles in DFT2 cells are common among host devils or non-polymorphic, reducing immunogenicity in a population sharing these alleles. In parallel, MHC class I loss is emerging in vivo, thus DFT2 may be mimicking the evolutionary trajectory of DFT1. Based on these results we propose that contagious cancers may exploit partial histocompatibility between the tumour and host, but that loss of allogeneic antigens could facilitate widespread transmission of DFT2.

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Accepted/In Press date: 9 July 2018
e-pub ahead of print date: 14 August 2018

Identifiers

Local EPrints ID: 425071
URI: http://eprints.soton.ac.uk/id/eprint/425071
ISSN: 2050-084X
PURE UUID: e0cad8d0-641b-4e04-893b-254ba4d67c56
ORCID for Rachel S. Owen: ORCID iD orcid.org/0000-0001-6441-2213
ORCID for Tim Elliott: ORCID iD orcid.org/0000-0003-1097-0222

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Date deposited: 10 Oct 2018 16:30
Last modified: 17 Dec 2019 01:52

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Contributors

Author: Alison Caldwell
Author: Rachel Coleby
Author: Cesar Tovar
Author: Maximilian R. Stammnitz
Author: Young Mi Kwon
Author: Rachel S. Owen ORCID iD
Author: Marios Tringides
Author: Elizabeth P. Murchison
Author: Karsten Skjødt
Author: Jim Kaufman
Author: Tim Elliott ORCID iD
Author: Gregory M. Woods

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