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Biophysical and structural studies of TCRs and ligands: Implications for T cell signaling

Biophysical and structural studies of TCRs and ligands: Implications for T cell signaling
Biophysical and structural studies of TCRs and ligands: Implications for T cell signaling

The availability of soluble αβ TCRs and the individual chains has now made it possible to carry-out structural studies of these molecules and analyze their molecular interactions with peptide-MHC ligands. Recent X-ray crystallographic structures of TCR α and β chains have finally established their structural similarity with the Ig molecules. Kinetic measurements of the interaction between TCRs and their ligands have provided strong evidence in favour of an affinity/avidity model for T cell activation in the periphery as well as during development in the thymus.

0952-7915
97-106
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Qadri, Ayub
c31c2ac2-aaa5-4236-907c-a96dfbc598e8
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Qadri, Ayub
c31c2ac2-aaa5-4236-907c-a96dfbc598e8

Ward, E. Sally and Qadri, Ayub (1997) Biophysical and structural studies of TCRs and ligands: Implications for T cell signaling. Current Opinion in Immunology, 9 (1), 97-106. (doi:10.1016/S0952-7915(97)80165-3).

Record type: Article

Abstract

The availability of soluble αβ TCRs and the individual chains has now made it possible to carry-out structural studies of these molecules and analyze their molecular interactions with peptide-MHC ligands. Recent X-ray crystallographic structures of TCR α and β chains have finally established their structural similarity with the Ig molecules. Kinetic measurements of the interaction between TCRs and their ligands have provided strong evidence in favour of an affinity/avidity model for T cell activation in the periphery as well as during development in the thymus.

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More information

Published date: February 1997

Identifiers

Local EPrints ID: 425119
URI: http://eprints.soton.ac.uk/id/eprint/425119
DOI: doi:10.1016/S0952-7915(97)80165-3
ISSN: 0952-7915
PURE UUID: c0fca955-c4a9-4f12-aa11-4f4ddfc71ce5
ORCID for E. Sally Ward: ORCID iD orcid.org/0000-0003-3232-7238

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Date deposited: 11 Oct 2018 16:30
Last modified: 16 Mar 2024 04:37

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Contributors

Author: E. Sally Ward ORCID iD
Author: Ayub Qadri

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