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FcRn: The MHC class I-related receptor that is more than an IgG transporter

FcRn: The MHC class I-related receptor that is more than an IgG transporter
FcRn: The MHC class I-related receptor that is more than an IgG transporter

Recent data have indicated that the major histocompatibility complex (MHC) class I-related receptor FcRn plays a role in regulating serum IgG levels, in addition to transferring maternal IgGs across the rodent neonatal gut. The isolation of a human homolog of FcRn from placenta suggests that the studies in rodents have relevance to understanding similar processes in humans. This has implications for the engineering of improved antibodies for therapy.

0167-5699
592-598
Ghetie, Victor
b7b50946-2bd9-4896-b841-6bbfba8237c2
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ghetie, Victor
b7b50946-2bd9-4896-b841-6bbfba8237c2
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc

Ghetie, Victor and Ward, E. Sally (1997) FcRn: The MHC class I-related receptor that is more than an IgG transporter. Immunology Today, 18 (12), 592-598. (doi:10.1016/S0167-5699(97)01172-9).

Record type: Review

Abstract

Recent data have indicated that the major histocompatibility complex (MHC) class I-related receptor FcRn plays a role in regulating serum IgG levels, in addition to transferring maternal IgGs across the rodent neonatal gut. The isolation of a human homolog of FcRn from placenta suggests that the studies in rodents have relevance to understanding similar processes in humans. This has implications for the engineering of improved antibodies for therapy.

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More information

Published date: December 1997

Identifiers

Local EPrints ID: 425120
URI: http://eprints.soton.ac.uk/id/eprint/425120
DOI: doi:10.1016/S0167-5699(97)01172-9
ISSN: 0167-5699
PURE UUID: 18a6d2ff-b55d-46f0-ba80-6e2cf785e2f9
ORCID for E. Sally Ward: ORCID iD orcid.org/0000-0003-3232-7238

Catalogue record

Date deposited: 11 Oct 2018 16:30
Last modified: 18 Mar 2024 03:48

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Contributors

Author: Victor Ghetie
Author: E. Sally Ward ORCID iD

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