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Identification and function of neonatal Fc receptor in mammary gland of lactating mice

Identification and function of neonatal Fc receptor in mammary gland of lactating mice
Identification and function of neonatal Fc receptor in mammary gland of lactating mice

In addition to its proposed function in regulating serum IgG levels, the MHC class I-related neonatal Fc receptor (FcRn) is known to play a role in IgG transfer across rodent yolk sac and neonatal intestine. In contrast to humans, for which transplacental transfer of IgG appears to be the only mechanism of maternal IgG delivery, the transmission of IgG in mice occurs both antenatally (yolk sac) and neonatally (transport from mother's milk across intestinal epithelial cells). In the current study, a possible role for FcRn in regulating IgG transfer into milk has been investigated. FcRn has been shown to be present in functional form in the mammary gland of lactating mice, and is localized to the epithelial cells of the acini. Analysis of the transfer of Fc fragments and IgG which have different affinities for FcRn indicate that, unexpectedly, these proteins are transferred in inverse correlation with their binding affinity for FcRn. Thus, in the lactating mammary gland FcRn appears to play a role in recycling IgG in a mode that may have relevance to FcRn trafficking during the maintenance of constant serum IgG levels.

IgG, Mammary gland, Neonatal Fc receptor, Transcytosis
0014-2980
2515-2523
Cianga, Petru
0c3783a1-22f2-40b9-80a6-9a580fef2477
Medesan, Corneliu
0de1d9e4-c8d9-4896-bcca-63f8b24e8f2c
Richardson, James A.
9e841767-2c36-4180-945f-a769588d8012
Ghetie, Victor
b7b50946-2bd9-4896-b841-6bbfba8237c2
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Cianga, Petru
0c3783a1-22f2-40b9-80a6-9a580fef2477
Medesan, Corneliu
0de1d9e4-c8d9-4896-bcca-63f8b24e8f2c
Richardson, James A.
9e841767-2c36-4180-945f-a769588d8012
Ghetie, Victor
b7b50946-2bd9-4896-b841-6bbfba8237c2
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc

Cianga, Petru, Medesan, Corneliu, Richardson, James A., Ghetie, Victor and Ward, E. Sally (1999) Identification and function of neonatal Fc receptor in mammary gland of lactating mice. European Journal of Immunology, 29 (8), 2515-2523. (doi:10.1002/(SICI)1521-4141(199908)29:08<2515::AID-IMMU2515>3.0.CO;2-D).

Record type: Article

Abstract

In addition to its proposed function in regulating serum IgG levels, the MHC class I-related neonatal Fc receptor (FcRn) is known to play a role in IgG transfer across rodent yolk sac and neonatal intestine. In contrast to humans, for which transplacental transfer of IgG appears to be the only mechanism of maternal IgG delivery, the transmission of IgG in mice occurs both antenatally (yolk sac) and neonatally (transport from mother's milk across intestinal epithelial cells). In the current study, a possible role for FcRn in regulating IgG transfer into milk has been investigated. FcRn has been shown to be present in functional form in the mammary gland of lactating mice, and is localized to the epithelial cells of the acini. Analysis of the transfer of Fc fragments and IgG which have different affinities for FcRn indicate that, unexpectedly, these proteins are transferred in inverse correlation with their binding affinity for FcRn. Thus, in the lactating mammary gland FcRn appears to play a role in recycling IgG in a mode that may have relevance to FcRn trafficking during the maintenance of constant serum IgG levels.

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More information

Published date: August 1999
Keywords: IgG, Mammary gland, Neonatal Fc receptor, Transcytosis

Identifiers

Local EPrints ID: 425127
URI: http://eprints.soton.ac.uk/id/eprint/425127
ISSN: 0014-2980
PURE UUID: a91b843b-183e-439f-b06c-b98f31767a6b
ORCID for E. Sally Ward: ORCID iD orcid.org/0000-0003-3232-7238

Catalogue record

Date deposited: 11 Oct 2018 16:30
Last modified: 07 Oct 2020 02:22

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Contributors

Author: Petru Cianga
Author: Corneliu Medesan
Author: James A. Richardson
Author: Victor Ghetie
Author: E. Sally Ward ORCID iD

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