T helper differentiation in resistant and susceptible B7-deficient mice infected with Leishmania major
T helper differentiation in resistant and susceptible B7-deficient mice infected with Leishmania major
The contribution of the costimulatory molecules B7-1 and B7-2 to the in vivo differentiation of Th cells remains controversial. The infection of resistant and susceptible strains of mice with the parasite Leishmania major provides a well-established model for studying in vivo differentiation of CD4+ T cells. We have infected B7-1/B7-2-deficient mice on the BALB/c and 129 background with L. major and subsequently examined different parameters of infection and cytokine responses upon restimulation of lymph node cells in vitro. BALB/c B7-2-deficient and B7-1/B7-2-double deficient mice are resistant to L. major, whereas BALB/c B7-1-deficient mice remain as susceptible as wild-type BALB/c mice. Differential expression of B7-1 and B7-2 can explain the distinct roles observed for these B7 costimulators in L. major infection.
Costimulation, Knockout, Parasitic, protozoan, Th1, Th2 cell, Transgenic
1764-1772
Bäcklund, Johan
b492facc-0572-4381-b0c9-2ea8af8af26a
Treschow, Alexandra
9c2c6783-2432-42a2-8f61-deffa412c224
Firan, Mihail
4eb11e8f-7fb6-483b-99d2-3f918a4325c5
Malmström, Vivianne
2f29bb3d-6136-4da9-8196-b580953f4bed
Issazadeh-Navikas, Shohreh
58d9e5d5-a444-4794-bb1e-48d0109989e7
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Holmdahl, Rikard
b6f8d2b9-b3d3-42d0-b450-20458767a8b4
June 2002
Bäcklund, Johan
b492facc-0572-4381-b0c9-2ea8af8af26a
Treschow, Alexandra
9c2c6783-2432-42a2-8f61-deffa412c224
Firan, Mihail
4eb11e8f-7fb6-483b-99d2-3f918a4325c5
Malmström, Vivianne
2f29bb3d-6136-4da9-8196-b580953f4bed
Issazadeh-Navikas, Shohreh
58d9e5d5-a444-4794-bb1e-48d0109989e7
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Holmdahl, Rikard
b6f8d2b9-b3d3-42d0-b450-20458767a8b4
Bäcklund, Johan, Treschow, Alexandra, Firan, Mihail, Malmström, Vivianne, Issazadeh-Navikas, Shohreh, Ward, E. Sally and Holmdahl, Rikard
(2002)
T helper differentiation in resistant and susceptible B7-deficient mice infected with Leishmania major.
European Journal of Immunology, 32 (6), .
(doi:10.1002/1521-4141(200206)32:6<1764::AID-IMMU1764>3.0.CO;2-V).
Abstract
The contribution of the costimulatory molecules B7-1 and B7-2 to the in vivo differentiation of Th cells remains controversial. The infection of resistant and susceptible strains of mice with the parasite Leishmania major provides a well-established model for studying in vivo differentiation of CD4+ T cells. We have infected B7-1/B7-2-deficient mice on the BALB/c and 129 background with L. major and subsequently examined different parameters of infection and cytokine responses upon restimulation of lymph node cells in vitro. BALB/c B7-2-deficient and B7-1/B7-2-double deficient mice are resistant to L. major, whereas BALB/c B7-1-deficient mice remain as susceptible as wild-type BALB/c mice. Differential expression of B7-1 and B7-2 can explain the distinct roles observed for these B7 costimulators in L. major infection.
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Accepted/In Press date: 9 April 2002
Published date: June 2002
Keywords:
Costimulation, Knockout, Parasitic, protozoan, Th1, Th2 cell, Transgenic
Identifiers
Local EPrints ID: 425139
URI: http://eprints.soton.ac.uk/id/eprint/425139
ISSN: 0014-2980
PURE UUID: e9a79b08-ee94-49b0-9030-da711a2906e5
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Date deposited: 11 Oct 2018 16:30
Last modified: 16 Mar 2024 04:37
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Contributors
Author:
Johan Bäcklund
Author:
Alexandra Treschow
Author:
Mihail Firan
Author:
Vivianne Malmström
Author:
Shohreh Issazadeh-Navikas
Author:
Rikard Holmdahl
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