Transcytosis and catabolism of antibody
Transcytosis and catabolism of antibody
This review describes the evolution of our knowledge of the transmission of immunoglobulin G (IgG) from mother to infant and the factors which regulate the persistence of IgG in the circulation. These apparently unrelated processes involve the same Fc receptor, FcRn (n = neonatal). FcRn appears to carry out these diverse roles by binding to IgG and then either transporting the bound IgG across cells (transcytosis) or recycling its cargo back to the cell surface (control of catabolism). IgG that is taken up by cells in the absence of binding to FcRn undergoes degradation. Thus, FcRn is the "protective" receptor that serves to maintain IgG homeostasis and deliver IgGs across cellular barriers.
Antibody, Catabolism, Fc receptor, Immunoglobulin G, Neonatal Fc receptor, Transcytosis
97-113
Ghetie, Victor
b7b50946-2bd9-4896-b841-6bbfba8237c2
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
2002
Ghetie, Victor
b7b50946-2bd9-4896-b841-6bbfba8237c2
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ghetie, Victor and Ward, E. Sally
(2002)
Transcytosis and catabolism of antibody.
Immunologic Research, 25 (2), .
(doi:10.1385/IR:25:2:097).
Abstract
This review describes the evolution of our knowledge of the transmission of immunoglobulin G (IgG) from mother to infant and the factors which regulate the persistence of IgG in the circulation. These apparently unrelated processes involve the same Fc receptor, FcRn (n = neonatal). FcRn appears to carry out these diverse roles by binding to IgG and then either transporting the bound IgG across cells (transcytosis) or recycling its cargo back to the cell surface (control of catabolism). IgG that is taken up by cells in the absence of binding to FcRn undergoes degradation. Thus, FcRn is the "protective" receptor that serves to maintain IgG homeostasis and deliver IgGs across cellular barriers.
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Published date: 2002
Keywords:
Antibody, Catabolism, Fc receptor, Immunoglobulin G, Neonatal Fc receptor, Transcytosis
Identifiers
Local EPrints ID: 425142
URI: http://eprints.soton.ac.uk/id/eprint/425142
ISSN: 0257-277X
PURE UUID: 5eda2835-1fc8-4477-b74f-8386ce801d97
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Date deposited: 11 Oct 2018 16:30
Last modified: 16 Mar 2024 04:37
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Author:
Victor Ghetie
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