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The MHC Class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland

The MHC Class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland
The MHC Class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland

The major histocompatibility complex (MHC) class I related neonatal Fc receptor (FcRn) plays multiple roles, being involved in transporting immunoglobulin G (IgG) and protecting this antibody class from catabolism. The presence of this receptor was previously demonstrated in the lactating murine mammary gland. In the current study we have investigated FcRn expression in various histologic types of human breast carcinoma and lymph node metastases. We used immunohistochemical methods to demonstrate the presence of FcRn in epithelial cells, whereas this Fc receptor could not be detected in mammary gland endothelial cells. The presence of the receptor was also found in the metastasizing epithelial cells within the lymph nodes, and this provides a useful marker for their identification.

Endothelial cells, Epithelial cells, FcRn, Mammary gland, Metastasis
0198-8859
1152-1159
Cianga, Petru
0c3783a1-22f2-40b9-80a6-9a580fef2477
Cianga, Corina
7c90f2c7-8627-44ea-8afa-7bf3e0abb0f6
Cozma, Laurette
bc0e4562-5015-4c88-941c-8822312ac65b
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Carasevici, Eugen
fe47d6e3-0d12-4b25-8887-7aff640c9105
Cianga, Petru
0c3783a1-22f2-40b9-80a6-9a580fef2477
Cianga, Corina
7c90f2c7-8627-44ea-8afa-7bf3e0abb0f6
Cozma, Laurette
bc0e4562-5015-4c88-941c-8822312ac65b
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Carasevici, Eugen
fe47d6e3-0d12-4b25-8887-7aff640c9105

Cianga, Petru, Cianga, Corina, Cozma, Laurette, Ward, E. Sally and Carasevici, Eugen (2003) The MHC Class I related Fc receptor, FcRn, is expressed in the epithelial cells of the human mammary gland. Human Immunology, 64 (12), 1152-1159. (doi:10.1016/j.humimm.2003.08.025).

Record type: Article

Abstract

The major histocompatibility complex (MHC) class I related neonatal Fc receptor (FcRn) plays multiple roles, being involved in transporting immunoglobulin G (IgG) and protecting this antibody class from catabolism. The presence of this receptor was previously demonstrated in the lactating murine mammary gland. In the current study we have investigated FcRn expression in various histologic types of human breast carcinoma and lymph node metastases. We used immunohistochemical methods to demonstrate the presence of FcRn in epithelial cells, whereas this Fc receptor could not be detected in mammary gland endothelial cells. The presence of the receptor was also found in the metastasizing epithelial cells within the lymph nodes, and this provides a useful marker for their identification.

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More information

Accepted/In Press date: 1 August 2003
e-pub ahead of print date: 10 September 2003
Published date: December 2003
Keywords: Endothelial cells, Epithelial cells, FcRn, Mammary gland, Metastasis

Identifiers

Local EPrints ID: 425149
URI: http://eprints.soton.ac.uk/id/eprint/425149
ISSN: 0198-8859
PURE UUID: 50e25abd-23d0-4a56-82e5-80084f03c4ef
ORCID for E. Sally Ward: ORCID iD orcid.org/0000-0003-3232-7238

Catalogue record

Date deposited: 11 Oct 2018 16:30
Last modified: 08 Jan 2022 03:36

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Contributors

Author: Petru Cianga
Author: Corina Cianga
Author: Laurette Cozma
Author: E. Sally Ward ORCID iD
Author: Eugen Carasevici

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