Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis
Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis
We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.
Antibodies, B lymphocytes, Gene rearrangement, Multiple sclerosis, Mutational signature
123-130
Cameron, Elizabeth M.
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Spencer, Sade
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Lazarini, Jonathan
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Harp, Christopher T.
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Ward, E. Sally
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Burgoon, Mark
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Owens, Gregory P.
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Racke, Michael K.
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Bennett, Jeffrey L.
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Frohman, Elliot M.
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Monson, Nancy L.
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18 August 2009
Cameron, Elizabeth M.
117633c8-2dc1-4e3a-ab1a-2b45c17789c3
Spencer, Sade
107d154d-8f89-4d6e-b7a8-199e6984a29f
Lazarini, Jonathan
55bce6d1-a2f8-4297-89f5-c1e1d2c147df
Harp, Christopher T.
52e117fb-3ff7-413d-94cf-bf4c49dd786e
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Burgoon, Mark
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Owens, Gregory P.
d563bbe4-95c9-47b5-813b-7d814c5ef4aa
Racke, Michael K.
fd372156-c5df-402d-82de-8ecc3a4bce3f
Bennett, Jeffrey L.
8219ec87-efc6-4b03-9acc-d618bf1a386a
Frohman, Elliot M.
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Monson, Nancy L.
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Cameron, Elizabeth M., Spencer, Sade, Lazarini, Jonathan, Harp, Christopher T., Ward, E. Sally, Burgoon, Mark, Owens, Gregory P., Racke, Michael K., Bennett, Jeffrey L., Frohman, Elliot M. and Monson, Nancy L.
(2009)
Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis.
Journal of Neuroimmunology, 213 (1-2), .
(doi:10.1016/j.jneuroim.2009.05.014).
Abstract
We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.
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More information
Accepted/In Press date: 29 May 2009
e-pub ahead of print date: 24 July 2009
Published date: 18 August 2009
Keywords:
Antibodies, B lymphocytes, Gene rearrangement, Multiple sclerosis, Mutational signature
Identifiers
Local EPrints ID: 425157
URI: http://eprints.soton.ac.uk/id/eprint/425157
ISSN: 0165-5728
PURE UUID: 867c9615-dace-4bec-99f4-22d4fa85c8d1
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Date deposited: 11 Oct 2018 16:30
Last modified: 16 Mar 2024 04:37
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Contributors
Author:
Elizabeth M. Cameron
Author:
Sade Spencer
Author:
Jonathan Lazarini
Author:
Christopher T. Harp
Author:
Mark Burgoon
Author:
Gregory P. Owens
Author:
Michael K. Racke
Author:
Jeffrey L. Bennett
Author:
Elliot M. Frohman
Author:
Nancy L. Monson
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