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Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis

Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis
Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis

We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.

Antibodies, B lymphocytes, Gene rearrangement, Multiple sclerosis, Mutational signature
0165-5728
123-130
Cameron, Elizabeth M.
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Spencer, Sade
107d154d-8f89-4d6e-b7a8-199e6984a29f
Lazarini, Jonathan
55bce6d1-a2f8-4297-89f5-c1e1d2c147df
Harp, Christopher T.
52e117fb-3ff7-413d-94cf-bf4c49dd786e
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Burgoon, Mark
314069e6-4aba-4e2a-b9aa-fe399b6a1b10
Owens, Gregory P.
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Racke, Michael K.
fd372156-c5df-402d-82de-8ecc3a4bce3f
Bennett, Jeffrey L.
8219ec87-efc6-4b03-9acc-d618bf1a386a
Frohman, Elliot M.
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Monson, Nancy L.
2fe3f326-3515-4c3f-bbce-f6f043bb5f61
Cameron, Elizabeth M.
117633c8-2dc1-4e3a-ab1a-2b45c17789c3
Spencer, Sade
107d154d-8f89-4d6e-b7a8-199e6984a29f
Lazarini, Jonathan
55bce6d1-a2f8-4297-89f5-c1e1d2c147df
Harp, Christopher T.
52e117fb-3ff7-413d-94cf-bf4c49dd786e
Ward, E. Sally
b31c0877-8abe-485f-b800-244a9d3cd6cc
Burgoon, Mark
314069e6-4aba-4e2a-b9aa-fe399b6a1b10
Owens, Gregory P.
d563bbe4-95c9-47b5-813b-7d814c5ef4aa
Racke, Michael K.
fd372156-c5df-402d-82de-8ecc3a4bce3f
Bennett, Jeffrey L.
8219ec87-efc6-4b03-9acc-d618bf1a386a
Frohman, Elliot M.
9f797b36-3012-46d0-b48f-0bbdd9c30f56
Monson, Nancy L.
2fe3f326-3515-4c3f-bbce-f6f043bb5f61

Cameron, Elizabeth M., Spencer, Sade, Lazarini, Jonathan, Harp, Christopher T., Ward, E. Sally, Burgoon, Mark, Owens, Gregory P., Racke, Michael K., Bennett, Jeffrey L., Frohman, Elliot M. and Monson, Nancy L. (2009) Potential of a unique antibody gene signature to predict conversion to clinically definite multiple sclerosis. Journal of Neuroimmunology, 213 (1-2), 123-130. (doi:10.1016/j.jneuroim.2009.05.014).

Record type: Article

Abstract

We identified a unique antibody gene mutation pattern (i.e. "signature") in cerebrospinal fluid (CSF) B cells from multiple sclerosis (MS) patients not present in control populations. Prevalence of the signature in CSF B cells of patients at risk to develop MS predicted conversion to MS with 91% accuracy in a small cohort of clinically isolated syndrome patients. If confirmed, signature prevalence would be a novel genetic diagnostic tool candidate for patients with early demyelinating disease of the central nervous system.

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More information

Accepted/In Press date: 29 May 2009
e-pub ahead of print date: 24 July 2009
Published date: 18 August 2009
Keywords: Antibodies, B lymphocytes, Gene rearrangement, Multiple sclerosis, Mutational signature

Identifiers

Local EPrints ID: 425157
URI: https://eprints.soton.ac.uk/id/eprint/425157
ISSN: 0165-5728
PURE UUID: 867c9615-dace-4bec-99f4-22d4fa85c8d1
ORCID for E. Sally Ward: ORCID iD orcid.org/0000-0003-3232-7238

Catalogue record

Date deposited: 11 Oct 2018 16:30
Last modified: 14 Mar 2019 01:21

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Contributors

Author: Elizabeth M. Cameron
Author: Sade Spencer
Author: Jonathan Lazarini
Author: Christopher T. Harp
Author: E. Sally Ward ORCID iD
Author: Mark Burgoon
Author: Gregory P. Owens
Author: Michael K. Racke
Author: Jeffrey L. Bennett
Author: Elliot M. Frohman
Author: Nancy L. Monson

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