The University of Southampton
University of Southampton Institutional Repository

The effector functions of immunoglobulins: Implications for therapy

The effector functions of immunoglobulins: Implications for therapy
The effector functions of immunoglobulins: Implications for therapy

The effector functions of immunoglobulins of the G class (IgGs) are essential for their effective use in therapy. The functions that operate following complex formation with cognate antigen involve binding to Clq (to mediate complement fixation) and the Fc receptors, FcγRI, II and III. Another class of functions that is independent of antigen binding encompasses the transfer of antibodies across the placenta and maintaining the levels in the serum. All effector functions of IgGs are conferred by sequences in the Fc region of antibodies, and this review discusses the localisation of the functions to specific amino acid residues. Such knowledge is of use for the further improvement of IgCs for therapy.

Antibody, Catabolism, Complement, Effector function, Fc receptor, Immunoglobulins, Maternal transfer
0967-0149
77-94
Ward, E. S.
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ghetie, V.
b7b50946-2bd9-4896-b841-6bbfba8237c2
Ward, E. S.
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ghetie, V.
b7b50946-2bd9-4896-b841-6bbfba8237c2

Ward, E. S. and Ghetie, V. (1995) The effector functions of immunoglobulins: Implications for therapy. Therapeutic Immunology, 2 (2), 77-94.

Record type: Review

Abstract

The effector functions of immunoglobulins of the G class (IgGs) are essential for their effective use in therapy. The functions that operate following complex formation with cognate antigen involve binding to Clq (to mediate complement fixation) and the Fc receptors, FcγRI, II and III. Another class of functions that is independent of antigen binding encompasses the transfer of antibodies across the placenta and maintaining the levels in the serum. All effector functions of IgGs are conferred by sequences in the Fc region of antibodies, and this review discusses the localisation of the functions to specific amino acid residues. Such knowledge is of use for the further improvement of IgCs for therapy.

Full text not available from this repository.

More information

Published date: 1995
Keywords: Antibody, Catabolism, Complement, Effector function, Fc receptor, Immunoglobulins, Maternal transfer

Identifiers

Local EPrints ID: 425251
URI: http://eprints.soton.ac.uk/id/eprint/425251
ISSN: 0967-0149
PURE UUID: e300c44f-7038-44c2-857e-18107f8092ae
ORCID for E. S. Ward: ORCID iD orcid.org/0000-0003-3232-7238

Catalogue record

Date deposited: 12 Oct 2018 16:30
Last modified: 14 Mar 2019 01:21

Export record

Contributors

Author: E. S. Ward ORCID iD
Author: V. Ghetie

University divisions

Download statistics

Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.

View more statistics

Atom RSS 1.0 RSS 2.0

Contact ePrints Soton: eprints@soton.ac.uk

ePrints Soton supports OAI 2.0 with a base URL of http://eprints.soton.ac.uk/cgi/oai2

This repository has been built using EPrints software, developed at the University of Southampton, but available to everyone to use.

We use cookies to ensure that we give you the best experience on our website. If you continue without changing your settings, we will assume that you are happy to receive cookies on the University of Southampton website.

×