The effector functions of immunoglobulins: Implications for therapy
The effector functions of immunoglobulins: Implications for therapy
The effector functions of immunoglobulins of the G class (IgGs) are essential for their effective use in therapy. The functions that operate following complex formation with cognate antigen involve binding to Clq (to mediate complement fixation) and the Fc receptors, FcγRI, II and III. Another class of functions that is independent of antigen binding encompasses the transfer of antibodies across the placenta and maintaining the levels in the serum. All effector functions of IgGs are conferred by sequences in the Fc region of antibodies, and this review discusses the localisation of the functions to specific amino acid residues. Such knowledge is of use for the further improvement of IgCs for therapy.
Antibody, Catabolism, Complement, Effector function, Fc receptor, Immunoglobulins, Maternal transfer
77-94
Ward, E. S.
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ghetie, V.
b7b50946-2bd9-4896-b841-6bbfba8237c2
1995
Ward, E. S.
b31c0877-8abe-485f-b800-244a9d3cd6cc
Ghetie, V.
b7b50946-2bd9-4896-b841-6bbfba8237c2
Ward, E. S. and Ghetie, V.
(1995)
The effector functions of immunoglobulins: Implications for therapy.
Therapeutic Immunology, 2 (2), .
Abstract
The effector functions of immunoglobulins of the G class (IgGs) are essential for their effective use in therapy. The functions that operate following complex formation with cognate antigen involve binding to Clq (to mediate complement fixation) and the Fc receptors, FcγRI, II and III. Another class of functions that is independent of antigen binding encompasses the transfer of antibodies across the placenta and maintaining the levels in the serum. All effector functions of IgGs are conferred by sequences in the Fc region of antibodies, and this review discusses the localisation of the functions to specific amino acid residues. Such knowledge is of use for the further improvement of IgCs for therapy.
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Published date: 1995
Keywords:
Antibody, Catabolism, Complement, Effector function, Fc receptor, Immunoglobulins, Maternal transfer
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Local EPrints ID: 425251
URI: http://eprints.soton.ac.uk/id/eprint/425251
ISSN: 0967-0149
PURE UUID: e300c44f-7038-44c2-857e-18107f8092ae
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Date deposited: 12 Oct 2018 16:30
Last modified: 12 Dec 2021 04:24
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Author:
V. Ghetie
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