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Does early-onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts

Does early-onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts
Does early-onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts
The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.

This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3–4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3–4 years of age.

Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18–2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31–3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08–2.09).

Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.
0903-1936
1-13
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Harskampe-van Ginkel, Margreet W
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Heinrich, Joachim
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Iniguez, Carmen
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Keil, Thomas
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Lehmann, Irina
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Maier, Dieter
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van Meel, Evelien R
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Mommers, Monique
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Murcia, Mario
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Porta, Daniela
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Standl, Marie
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Torrent, Maties
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Vrijkotte, Tanya G M
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Chatzi, Leda
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Contreras, Zuelma A
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Annesi-Maesano, Isabella
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Baïz, Nour
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Ekström, Sandra
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Keil, Thomas
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Lehmann, Irina
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Maier, Dieter
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van Meel, Evelien R
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Porta, Daniela
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Torrent, Maties
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Vrijkotte, Tanya G M
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Wijga, Alet H.
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Berhane, Kiros
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Gilliland, Frank
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Chatzi, Leda
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Contreras, Zuelma A, Chen, Zhanghua, Roumeliotaki, Theano, Annesi-Maesano, Isabella, Baïz, Nour, von Berg, Andrea, Bergström, Anna, Crozier, Sarah, Duijts, Liesbeth, Ekström, Sandra, Eller, Esben, Fantini, Maria P., Kjaer, Henrik F, Forastiere, Francesco, Gerhard, Beatrix, Gori, Davide, Harskampe-van Ginkel, Margreet W, Heinrich, Joachim, Iniguez, Carmen, Inskip, Hazel, Keil, Thomas, Kogevinas, Manolis, Lau, Susanne, Lehmann, Irina, Maier, Dieter, van Meel, Evelien R, Mommers, Monique, Murcia, Mario, Porta, Daniela, Smit, Henriette A., Standl, Marie, Stratakis, Nikos, Sunyer, Jordi, Thijs, Carel, Torrent, Maties, Vrijkotte, Tanya G M, Wijga, Alet H., Berhane, Kiros, Gilliland, Frank and Chatzi, Leda (2018) Does early-onset asthma increase childhood obesity risk? A pooled analysis of 16 European cohorts. European Respiratory Journal, 52 (3), 1-13. (doi:10.1183/13993003.00504-2018).

Record type: Article

Abstract

The parallel epidemics of childhood asthma and obesity over the past few decades have spurred research into obesity as a risk factor for asthma. However, little is known regarding the role of asthma in obesity incidence. We examined whether early-onset asthma and related phenotypes are associated with the risk of developing obesity in childhood.

This study includes 21 130 children born from 1990 to 2008 in Denmark, France, Germany, Greece, Italy, The Netherlands, Spain, Sweden and the UK. We followed non-obese children at 3–4 years of age for incident obesity up to 8 years of age. Physician-diagnosed asthma, wheezing and allergic rhinitis were assessed up to 3–4 years of age.

Children with physician-diagnosed asthma had a higher risk for incident obesity than those without asthma (adjusted hazard ratio (aHR) 1.66, 95% CI 1.18–2.33). Children with active asthma (wheeze in the last 12 months and physician-diagnosed asthma) exhibited a higher risk for obesity (aHR 1.98, 95% CI 1.31–3.00) than those without wheeze and asthma. Persistent wheezing was associated with increased risk for incident obesity compared to never wheezers (aHR 1.51, 95% CI 1.08–2.09).

Early-onset asthma and wheezing may contribute to an increased risk of developing obesity in later childhood.

Text
Obesity asthma manuscript ERJ final - Accepted Manuscript
Restricted to Repository staff only until 27 March 2020.
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Supplementary material ERJ final
Restricted to Repository staff only until 27 March 2020.
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More information

Accepted/In Press date: 30 July 2018
e-pub ahead of print date: 27 September 2018
Published date: September 2018

Identifiers

Local EPrints ID: 425285
URI: https://eprints.soton.ac.uk/id/eprint/425285
ISSN: 0903-1936
PURE UUID: c7a483e5-18bb-4ef4-ac4d-aca25a30747f
ORCID for Sarah Crozier: ORCID iD orcid.org/0000-0002-9524-1127
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749

Catalogue record

Date deposited: 12 Oct 2018 16:30
Last modified: 10 Dec 2019 01:53

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Contributors

Author: Zuelma A Contreras
Author: Zhanghua Chen
Author: Theano Roumeliotaki
Author: Isabella Annesi-Maesano
Author: Nour Baïz
Author: Andrea von Berg
Author: Anna Bergström
Author: Sarah Crozier ORCID iD
Author: Liesbeth Duijts
Author: Sandra Ekström
Author: Esben Eller
Author: Maria P. Fantini
Author: Henrik F Kjaer
Author: Francesco Forastiere
Author: Beatrix Gerhard
Author: Davide Gori
Author: Margreet W Harskampe-van Ginkel
Author: Joachim Heinrich
Author: Carmen Iniguez
Author: Hazel Inskip ORCID iD
Author: Thomas Keil
Author: Manolis Kogevinas
Author: Susanne Lau
Author: Irina Lehmann
Author: Dieter Maier
Author: Evelien R van Meel
Author: Monique Mommers
Author: Mario Murcia
Author: Daniela Porta
Author: Henriette A. Smit
Author: Marie Standl
Author: Nikos Stratakis
Author: Jordi Sunyer
Author: Carel Thijs
Author: Maties Torrent
Author: Tanya G M Vrijkotte
Author: Alet H. Wijga
Author: Kiros Berhane
Author: Frank Gilliland
Author: Leda Chatzi

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