Steele, Andrew J. (2018) Roring ahead with DOCK2. Blood, 132 (2), 115-116. (doi:10.1182/blood-2018-05-848382).
Abstract
In this issue of Blood, Hasan et al demonstrate that dedicator of cytokinesis 2 (DOCK2) can complex with receptor tyrosine kinase like orphan receptor 1 (ROR1) after Wnt5a treatment, leading to Rac1/2 activation and increased proliferation in chronic lymphocytic leukemia (CLL).
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