Novel biomarkers for patient stratification in colorectal cancer: A review of definitions, emerging concepts, and data
Novel biomarkers for patient stratification in colorectal cancer: A review of definitions, emerging concepts, and data
Colorectal cancer (CRC) treatment has become more personalised, incorporating a combination of the individual patient risk assessment, gene testing, and chemother apy with surgery for optimal care. The improvement of staging with high-resolution imaging has allowed more selective treatments, optimising survival outcomes. The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment, while reducing unnecessary morbidity for the patient. The search for biomarkers in CRC has been of significant interest, with questions remaining on their impact and applicability. The study of biomarkers can be broadly divided into metabolic, molecular, microRNA, epithelial-to-mesenchymal-transition (EMT), and imaging classes. Although numerous molecules have claimed to impact prognosis and treatment, their clinical application has been limited. Furthermore, routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice, as it increases cost and can adversely affect expectations of treatment. In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC. We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of microRNAs, analyze metabolic profiles, and highlight key findings for biomarker potential in the EMT pathway.
Biomarker, Colorectal cancer, Epithelial-tomesenchymal- transition pathway, Imaging biomarker, Metabolic biomarker, MicroRNA, Molecular biomarker, Tumour regression grade
145-158
Chand, Manish
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Keller, Deborah S.
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Mirnezami, Reza
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Bullock, Marc
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Bhangu, Aneel
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Moran, Brendan
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Tekkis, Paris P.
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Brown, Gina
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Mirnezami, Alex
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Berho, Mariana
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Chand, Manish
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Keller, Deborah S.
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Mirnezami, Reza
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Bullock, Marc
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Bhangu, Aneel
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Moran, Brendan
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Tekkis, Paris P.
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Brown, Gina
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Mirnezami, Alex
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Berho, Mariana
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Chand, Manish, Keller, Deborah S., Mirnezami, Reza, Bullock, Marc, Bhangu, Aneel, Moran, Brendan, Tekkis, Paris P., Brown, Gina, Mirnezami, Alex and Berho, Mariana
(2018)
Novel biomarkers for patient stratification in colorectal cancer: A review of definitions, emerging concepts, and data.
World Journal of Gastrointestinal Oncology, 10 (7), .
(doi:10.4251/wjgo.v10.i7.145).
Abstract
Colorectal cancer (CRC) treatment has become more personalised, incorporating a combination of the individual patient risk assessment, gene testing, and chemother apy with surgery for optimal care. The improvement of staging with high-resolution imaging has allowed more selective treatments, optimising survival outcomes. The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment, while reducing unnecessary morbidity for the patient. The search for biomarkers in CRC has been of significant interest, with questions remaining on their impact and applicability. The study of biomarkers can be broadly divided into metabolic, molecular, microRNA, epithelial-to-mesenchymal-transition (EMT), and imaging classes. Although numerous molecules have claimed to impact prognosis and treatment, their clinical application has been limited. Furthermore, routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice, as it increases cost and can adversely affect expectations of treatment. In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC. We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of microRNAs, analyze metabolic profiles, and highlight key findings for biomarker potential in the EMT pathway.
Text
WJGO-10-145
- Version of Record
More information
Accepted/In Press date: 8 June 2018
e-pub ahead of print date: 15 July 2018
Keywords:
Biomarker, Colorectal cancer, Epithelial-tomesenchymal- transition pathway, Imaging biomarker, Metabolic biomarker, MicroRNA, Molecular biomarker, Tumour regression grade
Identifiers
Local EPrints ID: 425334
URI: http://eprints.soton.ac.uk/id/eprint/425334
PURE UUID: d69a0db8-ee10-4b8f-8a9c-2813b9a1c3bb
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Date deposited: 12 Oct 2018 16:30
Last modified: 15 Mar 2024 21:06
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Contributors
Author:
Manish Chand
Author:
Deborah S. Keller
Author:
Reza Mirnezami
Author:
Marc Bullock
Author:
Aneel Bhangu
Author:
Brendan Moran
Author:
Paris P. Tekkis
Author:
Gina Brown
Author:
Mariana Berho
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