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Brain iron in sickle cell disease?

Brain iron in sickle cell disease?
Brain iron in sickle cell disease?
In this issue of Blood, Miao et al have investigated the role of brain iron accumulation and silent cerebral infarction (SCI) in sickle cell disease (SCD), as well as considered whether these pathologies might be connected. Although iron deposition may play a crucial role in organ damage in SCD, the mechanisms involved are unclear, and there are few studies in the brain. To investigate further, Miao et al exploited the emerging technique of magnetic resonance imaging (MRI) quantitative susceptibility mapping (QSM), which provides a measure of tissue magnetic susceptibility that is strongly correlated with its iron content. They report QSM evidence for iron accumulation in the putamen, substantia nigra, and red nucleus in adolescent and young adult patients with SCD compared with controls. They also found significantly higher susceptibility in the globus pallidus and substantia nigra of SCD patients with SCI. When combining SCD patients with controls, they found a significant increase in susceptibility with age in the substantia nigra (see figure) and other deep gray matter regions, as originally documented histologically and confirmed in R2* and QSM MRI studies in healthy people.
Journal Article
0006-4971
1550-1552
Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Shmueli, Karin
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Kirkham, Fenella J.
1dfbc0d5-aebe-4439-9fb2-dac6503bcd58
Shmueli, Karin
798cb91b-1093-4011-ab38-461be7db9bfa

Kirkham, Fenella J. and Shmueli, Karin (2018) Brain iron in sickle cell disease? Blood, 132 (15), 1550-1552. (doi:10.1182/blood-2018-08-867010).

Record type: Article

Abstract

In this issue of Blood, Miao et al have investigated the role of brain iron accumulation and silent cerebral infarction (SCI) in sickle cell disease (SCD), as well as considered whether these pathologies might be connected. Although iron deposition may play a crucial role in organ damage in SCD, the mechanisms involved are unclear, and there are few studies in the brain. To investigate further, Miao et al exploited the emerging technique of magnetic resonance imaging (MRI) quantitative susceptibility mapping (QSM), which provides a measure of tissue magnetic susceptibility that is strongly correlated with its iron content. They report QSM evidence for iron accumulation in the putamen, substantia nigra, and red nucleus in adolescent and young adult patients with SCD compared with controls. They also found significantly higher susceptibility in the globus pallidus and substantia nigra of SCD patients with SCI. When combining SCD patients with controls, they found a significant increase in susceptibility with age in the substantia nigra (see figure) and other deep gray matter regions, as originally documented histologically and confirmed in R2* and QSM MRI studies in healthy people.

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BLOOD 2018 867010v3 Kirkham - Accepted Manuscript
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Accepted/In Press date: 17 August 2018
e-pub ahead of print date: 11 October 2018
Published date: 11 October 2018
Keywords: Journal Article

Identifiers

Local EPrints ID: 425370
URI: http://eprints.soton.ac.uk/id/eprint/425370
ISSN: 0006-4971
PURE UUID: 9ee55725-0b59-4e0a-a876-37f171053ad8
ORCID for Fenella J. Kirkham: ORCID iD orcid.org/0000-0002-2443-7958

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Date deposited: 16 Oct 2018 16:30
Last modified: 16 Mar 2024 07:10

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Author: Karin Shmueli

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