FUT2 Genetic Variants and reported respiratory and gastrointestinal illnesses during infancy
FUT2 Genetic Variants and reported respiratory and gastrointestinal illnesses during infancy
Background
Fucosyltransferase 2 (FUT2) controls the production of digestive and respiratory epithelia of histo-blood group antigens involved in the attachment of pathogens. The aim of our study was to relate FUT2 variants to reported gastrointestinal and respiratory illnesses in infancy.
Methods
In the Southampton Women’s Survey, FUT2 genetic variants (single-nucleotide polymorphisms [SNPs] rs601338 and rs602662) were genotyped in 1831 infants and related to infant illnesses, after adjustment for sex, breastfeeding duration, and potential confounders.
Results
For FUT2 SNP rs601338, the risk ratios for ≥1 bout of diarrhea during ages 6–12 months and ages 12–24 months per additional risk (G) allele were 1.23 (95% confidence interval [CI], 1.08–1.4; P = .002) and 1.41 (95% CI, 1.24–1.61; P = 1.7 × 10−7), respectively; the risk ratio for ≥1 diagnosis of a lower respiratory illness (ie, pneumonia or bronchiolitis) during ages 12–24 months per additional G allele was 2.66 (95% CI, 1.64–4.3; P = .00007). Similar associations were found between rs602662 and gastrointestinal and respiratory illnesses, owing to the high linkage disequilibrium with rs601338 (R2 = 0.92). Longer breastfeeding duration predicted a lower risk of diarrhea, independent of infant FUT2 genotype.
Conclusions
We confirmed that FUT2 G alleles are associated with a higher risk of infant gastrointestinal illnesses and identified novel associations with respiratory illnesses. FUT2 locus variants need consideration in future studies of gastrointestinal and respiratory illnesses among infants.
836–843
Barton, Sheila
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Murray, Robert
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Lillycrop, Karen
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Inskip, Hazel
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Harvey, Nicholas
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Cooper, Cyrus
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Karnani, Neerja
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Zolezzi, Irma Silva
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Sprenger, Norbert
a1110bf8-407f-4bfb-be1e-905b05f30bbe
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Binia, Aristea
3807fc06-aaaf-49ab-af3a-c6982da58b5a
15 February 2019
Barton, Sheila
4f674382-ca0b-44ad-9670-e71a0b134ef0
Murray, Robert
c3e973b5-525c-49b3-96ee-af60a666a0f4
Lillycrop, Karen
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Karnani, Neerja
1f3bc109-4c37-4af3-9db9-ad09310e757b
Zolezzi, Irma Silva
0b06261f-7fda-4e53-9b88-6a7fa51cf85e
Sprenger, Norbert
a1110bf8-407f-4bfb-be1e-905b05f30bbe
Godfrey, Keith
0931701e-fe2c-44b5-8f0d-ec5c7477a6fd
Binia, Aristea
3807fc06-aaaf-49ab-af3a-c6982da58b5a
Barton, Sheila, Murray, Robert, Lillycrop, Karen, Inskip, Hazel, Harvey, Nicholas, Cooper, Cyrus, Karnani, Neerja, Zolezzi, Irma Silva, Sprenger, Norbert, Godfrey, Keith and Binia, Aristea
(2019)
FUT2 Genetic Variants and reported respiratory and gastrointestinal illnesses during infancy.
The Journal of Infectious Diseases, 219 (5), .
(doi:10.1093/infdis/jiy582).
Abstract
Background
Fucosyltransferase 2 (FUT2) controls the production of digestive and respiratory epithelia of histo-blood group antigens involved in the attachment of pathogens. The aim of our study was to relate FUT2 variants to reported gastrointestinal and respiratory illnesses in infancy.
Methods
In the Southampton Women’s Survey, FUT2 genetic variants (single-nucleotide polymorphisms [SNPs] rs601338 and rs602662) were genotyped in 1831 infants and related to infant illnesses, after adjustment for sex, breastfeeding duration, and potential confounders.
Results
For FUT2 SNP rs601338, the risk ratios for ≥1 bout of diarrhea during ages 6–12 months and ages 12–24 months per additional risk (G) allele were 1.23 (95% confidence interval [CI], 1.08–1.4; P = .002) and 1.41 (95% CI, 1.24–1.61; P = 1.7 × 10−7), respectively; the risk ratio for ≥1 diagnosis of a lower respiratory illness (ie, pneumonia or bronchiolitis) during ages 12–24 months per additional G allele was 2.66 (95% CI, 1.64–4.3; P = .00007). Similar associations were found between rs602662 and gastrointestinal and respiratory illnesses, owing to the high linkage disequilibrium with rs601338 (R2 = 0.92). Longer breastfeeding duration predicted a lower risk of diarrhea, independent of infant FUT2 genotype.
Conclusions
We confirmed that FUT2 G alleles are associated with a higher risk of infant gastrointestinal illnesses and identified novel associations with respiratory illnesses. FUT2 locus variants need consideration in future studies of gastrointestinal and respiratory illnesses among infants.
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Barton et al FUT2 Infections JID revised kg (2)
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Accepted/In Press date: 25 October 2018
e-pub ahead of print date: 30 October 2018
Published date: 15 February 2019
Identifiers
Local EPrints ID: 425742
URI: http://eprints.soton.ac.uk/id/eprint/425742
ISSN: 0022-1899
PURE UUID: 2f240fab-1ed4-4ee8-88b7-61f595282213
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Date deposited: 02 Nov 2018 17:30
Last modified: 18 Mar 2024 05:12
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Contributors
Author:
Robert Murray
Author:
Neerja Karnani
Author:
Irma Silva Zolezzi
Author:
Norbert Sprenger
Author:
Aristea Binia
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