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FUT2 Genetic Variants and reported respiratory and gastrointestinal illnesses during infancy

FUT2 Genetic Variants and reported respiratory and gastrointestinal illnesses during infancy
FUT2 Genetic Variants and reported respiratory and gastrointestinal illnesses during infancy
Background

Fucosyltransferase 2 (FUT2) controls the production of digestive and respiratory epithelia of histo-blood group antigens involved in the attachment of pathogens. The aim of our study was to relate FUT2 variants to reported gastrointestinal and respiratory illnesses in infancy.

Methods

In the Southampton Women’s Survey, FUT2 genetic variants (single-nucleotide polymorphisms [SNPs] rs601338 and rs602662) were genotyped in 1831 infants and related to infant illnesses, after adjustment for sex, breastfeeding duration, and potential confounders.

Results

For FUT2 SNP rs601338, the risk ratios for ≥1 bout of diarrhea during ages 6–12 months and ages 12–24 months per additional risk (G) allele were 1.23 (95% confidence interval [CI], 1.08–1.4; P = .002) and 1.41 (95% CI, 1.24–1.61; P = 1.7 × 10−7), respectively; the risk ratio for ≥1 diagnosis of a lower respiratory illness (ie, pneumonia or bronchiolitis) during ages 12–24 months per additional G allele was 2.66 (95% CI, 1.64–4.3; P = .00007). Similar associations were found between rs602662 and gastrointestinal and respiratory illnesses, owing to the high linkage disequilibrium with rs601338 (R2 = 0.92). Longer breastfeeding duration predicted a lower risk of diarrhea, independent of infant FUT2 genotype.

Conclusions

We confirmed that FUT2 G alleles are associated with a higher risk of infant gastrointestinal illnesses and identified novel associations with respiratory illnesses. FUT2 locus variants need consideration in future studies of gastrointestinal and respiratory illnesses among infants.
0022-1899
836–843
Barton, Sheila
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Murray, Robert
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Lillycrop, Karen
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Inskip, Hazel
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Harvey, Nicholas
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Cooper, Cyrus
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Karnani, Neerja
1f3bc109-4c37-4af3-9db9-ad09310e757b
Zolezzi, Irma Silva
0b06261f-7fda-4e53-9b88-6a7fa51cf85e
Sprenger, Norbert
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Godfrey, Keith
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Binia, Aristea
3807fc06-aaaf-49ab-af3a-c6982da58b5a
Barton, Sheila
4f674382-ca0b-44ad-9670-e71a0b134ef0
Murray, Robert
c3e973b5-525c-49b3-96ee-af60a666a0f4
Lillycrop, Karen
eeaaa78d-0c4d-4033-a178-60ce7345a2cc
Inskip, Hazel
5fb4470a-9379-49b2-a533-9da8e61058b7
Harvey, Nicholas
ce487fb4-d360-4aac-9d17-9466d6cba145
Cooper, Cyrus
e05f5612-b493-4273-9b71-9e0ce32bdad6
Karnani, Neerja
1f3bc109-4c37-4af3-9db9-ad09310e757b
Zolezzi, Irma Silva
0b06261f-7fda-4e53-9b88-6a7fa51cf85e
Sprenger, Norbert
a1110bf8-407f-4bfb-be1e-905b05f30bbe
Godfrey, Keith
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Binia, Aristea
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Barton, Sheila, Murray, Robert, Lillycrop, Karen, Inskip, Hazel, Harvey, Nicholas, Cooper, Cyrus, Karnani, Neerja, Zolezzi, Irma Silva, Sprenger, Norbert, Godfrey, Keith and Binia, Aristea (2019) FUT2 Genetic Variants and reported respiratory and gastrointestinal illnesses during infancy. The Journal of Infectious Diseases, 219 (5), 836–843. (doi:10.1093/infdis/jiy582).

Record type: Article

Abstract

Background

Fucosyltransferase 2 (FUT2) controls the production of digestive and respiratory epithelia of histo-blood group antigens involved in the attachment of pathogens. The aim of our study was to relate FUT2 variants to reported gastrointestinal and respiratory illnesses in infancy.

Methods

In the Southampton Women’s Survey, FUT2 genetic variants (single-nucleotide polymorphisms [SNPs] rs601338 and rs602662) were genotyped in 1831 infants and related to infant illnesses, after adjustment for sex, breastfeeding duration, and potential confounders.

Results

For FUT2 SNP rs601338, the risk ratios for ≥1 bout of diarrhea during ages 6–12 months and ages 12–24 months per additional risk (G) allele were 1.23 (95% confidence interval [CI], 1.08–1.4; P = .002) and 1.41 (95% CI, 1.24–1.61; P = 1.7 × 10−7), respectively; the risk ratio for ≥1 diagnosis of a lower respiratory illness (ie, pneumonia or bronchiolitis) during ages 12–24 months per additional G allele was 2.66 (95% CI, 1.64–4.3; P = .00007). Similar associations were found between rs602662 and gastrointestinal and respiratory illnesses, owing to the high linkage disequilibrium with rs601338 (R2 = 0.92). Longer breastfeeding duration predicted a lower risk of diarrhea, independent of infant FUT2 genotype.

Conclusions

We confirmed that FUT2 G alleles are associated with a higher risk of infant gastrointestinal illnesses and identified novel associations with respiratory illnesses. FUT2 locus variants need consideration in future studies of gastrointestinal and respiratory illnesses among infants.

Text
Barton et al FUT2 Infections JID revised kg (2) - Accepted Manuscript
Restricted to Repository staff only until 30 October 2019.
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Text
Barton_et_al_FUT2_Infections_JID_revised kg - Accepted Manuscript
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More information

Accepted/In Press date: 25 October 2018
e-pub ahead of print date: 30 October 2018
Published date: 15 February 2019

Identifiers

Local EPrints ID: 425742
URI: https://eprints.soton.ac.uk/id/eprint/425742
ISSN: 0022-1899
PURE UUID: 2f240fab-1ed4-4ee8-88b7-61f595282213
ORCID for Sheila Barton: ORCID iD orcid.org/0000-0003-4963-4242
ORCID for Karen Lillycrop: ORCID iD orcid.org/0000-0001-7350-5489
ORCID for Hazel Inskip: ORCID iD orcid.org/0000-0001-8897-1749
ORCID for Nicholas Harvey: ORCID iD orcid.org/0000-0002-8194-2512
ORCID for Cyrus Cooper: ORCID iD orcid.org/0000-0003-3510-0709
ORCID for Keith Godfrey: ORCID iD orcid.org/0000-0002-4643-0618

Catalogue record

Date deposited: 02 Nov 2018 17:30
Last modified: 15 Aug 2019 00:56

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Contributors

Author: Sheila Barton ORCID iD
Author: Robert Murray
Author: Karen Lillycrop ORCID iD
Author: Hazel Inskip ORCID iD
Author: Nicholas Harvey ORCID iD
Author: Cyrus Cooper ORCID iD
Author: Neerja Karnani
Author: Irma Silva Zolezzi
Author: Norbert Sprenger
Author: Keith Godfrey ORCID iD
Author: Aristea Binia

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