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Aggrecan directs extracellular matrix mediated neuronal plasticity

Aggrecan directs extracellular matrix mediated neuronal plasticity
Aggrecan directs extracellular matrix mediated neuronal plasticity
In the adult brain, the extracellular matrix (ECM) influences recovery after injury,susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity. The proteoglycan aggrecan is a core component of the condensed ECM structures termed perineuronal nets (PNNs), and the specific role of PNNs on neural plasticity remains elusive. Here, we genetically targeted the Acan gene encoding for aggrecan utilizing a novel animal model. This allowed for conditional and targeted loss of aggrecan in vivo, which ablated the PNN structure and caused a shift in the population of parvalbumin expressing inhibitory interneurons towards a high plasticity state. Selective deletion of the Acan gene in the visual cortex of male adult mice reinstated juvenile ocular dominance plasticity, which was mechanistically identical to critical period plasticity. Brain-wide targeting improved object recognition memory.
0270-6474
10102-10113
Rowlands, Daire
5ccd0f2a-45c4-4d2d-8344-deb3d1686e85
lensjo, Kristian K.
f856f4c0-c1c6-4c51-a30b-05132f649af9
Dinh, Tovy
a31d85ab-d608-4d4b-a220-732b18371676
yang, sujeong
88f03706-f565-4362-9841-d27a9beeba31
Andrews, Melissa
ae987a2f-878e-4ae3-a7a3-a7170712096c
Hafting, Torkel
bd4bc99b-2a71-44bb-af3f-b74a2de7ad91
Fyhn, Marianne
aec3b183-94c7-4412-b477-b8c8ceeb7c17
Fawcett, J.W.
9fda4f52-4374-44cd-9ebd-b09558caa694
Dick, Gunnar
db6b31b0-a4ed-498a-9681-f70c61305a14
Rowlands, Daire
5ccd0f2a-45c4-4d2d-8344-deb3d1686e85
lensjo, Kristian K.
f856f4c0-c1c6-4c51-a30b-05132f649af9
Dinh, Tovy
a31d85ab-d608-4d4b-a220-732b18371676
yang, sujeong
88f03706-f565-4362-9841-d27a9beeba31
Andrews, Melissa
ae987a2f-878e-4ae3-a7a3-a7170712096c
Hafting, Torkel
bd4bc99b-2a71-44bb-af3f-b74a2de7ad91
Fyhn, Marianne
aec3b183-94c7-4412-b477-b8c8ceeb7c17
Fawcett, J.W.
9fda4f52-4374-44cd-9ebd-b09558caa694
Dick, Gunnar
db6b31b0-a4ed-498a-9681-f70c61305a14

Rowlands, Daire, lensjo, Kristian K., Dinh, Tovy, yang, sujeong, Andrews, Melissa, Hafting, Torkel, Fyhn, Marianne, Fawcett, J.W. and Dick, Gunnar (2018) Aggrecan directs extracellular matrix mediated neuronal plasticity. The Journal of Neuroscience, 38 (47), 10102-10113. (doi:10.1523/JNEUROSCI.1122-18.2018).

Record type: Article

Abstract

In the adult brain, the extracellular matrix (ECM) influences recovery after injury,susceptibility to mental disorders, and is in general a strong regulator of neuronal plasticity. The proteoglycan aggrecan is a core component of the condensed ECM structures termed perineuronal nets (PNNs), and the specific role of PNNs on neural plasticity remains elusive. Here, we genetically targeted the Acan gene encoding for aggrecan utilizing a novel animal model. This allowed for conditional and targeted loss of aggrecan in vivo, which ablated the PNN structure and caused a shift in the population of parvalbumin expressing inhibitory interneurons towards a high plasticity state. Selective deletion of the Acan gene in the visual cortex of male adult mice reinstated juvenile ocular dominance plasticity, which was mechanistically identical to critical period plasticity. Brain-wide targeting improved object recognition memory.

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More information

Accepted/In Press date: 20 September 2018
e-pub ahead of print date: 3 October 2018
Published date: 21 November 2018

Identifiers

Local EPrints ID: 425761
URI: http://eprints.soton.ac.uk/id/eprint/425761
ISSN: 0270-6474
PURE UUID: 64ec6ed1-4e2d-43fa-903f-7c624710ebba
ORCID for Melissa Andrews: ORCID iD orcid.org/0000-0001-5960-5619

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Date deposited: 02 Nov 2018 17:30
Last modified: 26 Nov 2021 05:13

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Contributors

Author: Daire Rowlands
Author: Kristian K. lensjo
Author: Tovy Dinh
Author: sujeong yang
Author: Melissa Andrews ORCID iD
Author: Torkel Hafting
Author: Marianne Fyhn
Author: J.W. Fawcett
Author: Gunnar Dick

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