Stability of mitotic spindle using computational mechanics
Stability of mitotic spindle using computational mechanics
Fidelity of cell division depends on the ability of an internal cell structure called the mitotic spindle, to maintain the structural integrity of the cellular architecture despite being subject to high compressive loading. We propose a generic software tool called Spindle FEA that employs continuum mechanics and finite elements analysis (FEA) code Abaqus CAE to study the stability of mitotic spindles in various phases of mitosis. The proposed application has a modular structure which allows easy modification of any part of the analysis which is of particular importance considering that new knowledge of spindles is constantly emerging. Thanks to the highly optimised finite element solver used in Abaqus CAE, Spindle FEA is highly suitable for large multi- parametric studies which in turn may significantly benefit the planning of new experiments or identifying new key properties of the spindle. We also discuss the main physiological properties of spindles and show how they are modelled with the proposed technique as well as discuss all the essential analysis steps. We use Spindle FEA to study the buckling of a mitotic spindle in anaphase B to show how the additional stiffness of the lateral support of the spindle affects the left-right symmetry of cell division as well as to demonstrate the capacities of the proposed technique.
Cell division, mitotic spindle stability, anaphase B
67-74
Association for Computing Machinery
Iakovliev, Andrii
8f2242a2-fb0e-4603-aed8-f17331846df7
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e
January 2019
Iakovliev, Andrii
8f2242a2-fb0e-4603-aed8-f17331846df7
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e
Iakovliev, Andrii, Dasmahapatra, Srinandan and Bhaskar, Atul
(2019)
Stability of mitotic spindle using computational mechanics.
In ICBBB '19 Proceedings of the 2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics.
Association for Computing Machinery.
.
(doi:10.1145/3314367.3314373).
Record type:
Conference or Workshop Item
(Paper)
Abstract
Fidelity of cell division depends on the ability of an internal cell structure called the mitotic spindle, to maintain the structural integrity of the cellular architecture despite being subject to high compressive loading. We propose a generic software tool called Spindle FEA that employs continuum mechanics and finite elements analysis (FEA) code Abaqus CAE to study the stability of mitotic spindles in various phases of mitosis. The proposed application has a modular structure which allows easy modification of any part of the analysis which is of particular importance considering that new knowledge of spindles is constantly emerging. Thanks to the highly optimised finite element solver used in Abaqus CAE, Spindle FEA is highly suitable for large multi- parametric studies which in turn may significantly benefit the planning of new experiments or identifying new key properties of the spindle. We also discuss the main physiological properties of spindles and show how they are modelled with the proposed technique as well as discuss all the essential analysis steps. We use Spindle FEA to study the buckling of a mitotic spindle in anaphase B to show how the additional stiffness of the lateral support of the spindle affects the left-right symmetry of cell division as well as to demonstrate the capacities of the proposed technique.
Text
ICBBB2019_Iakovliev
- Accepted Manuscript
More information
Accepted/In Press date: 31 August 2018
Published date: January 2019
Venue - Dates:
2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics, National University of Singapore, Singapore, Singapore, 2019-01-07 - 2019-01-09
Keywords:
Cell division, mitotic spindle stability, anaphase B
Identifiers
Local EPrints ID: 425777
URI: http://eprints.soton.ac.uk/id/eprint/425777
PURE UUID: 6f7313be-aa2a-4290-8f05-b6cc6eff2ed4
Catalogue record
Date deposited: 02 Nov 2018 17:30
Last modified: 17 Mar 2024 05:10
Export record
Altmetrics
Contributors
Author:
Andrii Iakovliev
Author:
Srinandan Dasmahapatra
Download statistics
Downloads from ePrints over the past year. Other digital versions may also be available to download e.g. from the publisher's website.
View more statistics