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Stability of mitotic spindle using computational mechanics

Stability of mitotic spindle using computational mechanics
Stability of mitotic spindle using computational mechanics
Fidelity of cell division depends on the ability of an internal cell structure called the mitotic spindle, to maintain the structural integrity of the cellular architecture despite being subject to high compressive loading. We propose a generic software tool called Spindle FEA that employs continuum mechanics and finite elements analysis (FEA) code Abaqus CAE to study the stability of mitotic spindles in various phases of mitosis. The proposed application has a modular structure which allows easy modification of any part of the analysis which is of particular importance considering that new knowledge of spindles is constantly emerging. Thanks to the highly optimised finite element solver used in Abaqus CAE, Spindle FEA is highly suitable for large multi- parametric studies which in turn may significantly benefit the planning of new experiments or identifying new key properties of the spindle. We also discuss the main physiological properties of spindles and show how they are modelled with the proposed technique as well as discuss all the essential analysis steps. We use Spindle FEA to study the buckling of a mitotic spindle in anaphase B to show how the additional stiffness of the lateral support of the spindle affects the left-right symmetry of cell division as well as to demonstrate the capacities of the proposed technique.
Cell division, mitotic spindle stability, anaphase B
Iakovliev, Andrii
8f2242a2-fb0e-4603-aed8-f17331846df7
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e
Iakovliev, Andrii
8f2242a2-fb0e-4603-aed8-f17331846df7
Dasmahapatra, Srinandan
eb5fd76f-4335-4ae9-a88a-20b9e2b3f698
Bhaskar, Atul
d4122e7c-5bf3-415f-9846-5b0fed645f3e

Iakovliev, Andrii, Dasmahapatra, Srinandan and Bhaskar, Atul (2018) Stability of mitotic spindle using computational mechanics. 2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics, Singapore, Singapore. 07 - 09 Jan 2019. 8 pp . (In Press)

Record type: Conference or Workshop Item (Paper)

Abstract

Fidelity of cell division depends on the ability of an internal cell structure called the mitotic spindle, to maintain the structural integrity of the cellular architecture despite being subject to high compressive loading. We propose a generic software tool called Spindle FEA that employs continuum mechanics and finite elements analysis (FEA) code Abaqus CAE to study the stability of mitotic spindles in various phases of mitosis. The proposed application has a modular structure which allows easy modification of any part of the analysis which is of particular importance considering that new knowledge of spindles is constantly emerging. Thanks to the highly optimised finite element solver used in Abaqus CAE, Spindle FEA is highly suitable for large multi- parametric studies which in turn may significantly benefit the planning of new experiments or identifying new key properties of the spindle. We also discuss the main physiological properties of spindles and show how they are modelled with the proposed technique as well as discuss all the essential analysis steps. We use Spindle FEA to study the buckling of a mitotic spindle in anaphase B to show how the additional stiffness of the lateral support of the spindle affects the left-right symmetry of cell division as well as to demonstrate the capacities of the proposed technique.

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ICBBB2019_Iakovliev - Accepted Manuscript
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More information

Accepted/In Press date: 31 August 2018
Venue - Dates: 2019 9th International Conference on Bioscience, Biochemistry and Bioinformatics, Singapore, Singapore, 2019-01-07 - 2019-01-09
Keywords: Cell division, mitotic spindle stability, anaphase B

Identifiers

Local EPrints ID: 425777
URI: https://eprints.soton.ac.uk/id/eprint/425777
PURE UUID: 6f7313be-aa2a-4290-8f05-b6cc6eff2ed4
ORCID for Andrii Iakovliev: ORCID iD orcid.org/0000-0003-4031-0073

Catalogue record

Date deposited: 02 Nov 2018 17:30
Last modified: 14 Mar 2019 05:03

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Contributors

Author: Andrii Iakovliev ORCID iD
Author: Srinandan Dasmahapatra
Author: Atul Bhaskar

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