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Comparison of two methods of determining lung de-recruitment, using the forced oscillation technique

Comparison of two methods of determining lung de-recruitment, using the forced oscillation technique
Comparison of two methods of determining lung de-recruitment, using the forced oscillation technique

Airway closure has proved to be important in a number of respiratory diseases and may be the primary functional defect in asthma. A surrogate measure of closing volume can be identified using the forced oscillation technique (FOT), by performing a deflation maneuver and examining the resultant reactance (Xrs) lung volume relationship. This study aims to determine if a slow vital capacity maneuver can be used instead of this deflation maneuver and compare it to existing more complex techniques. Three subject groups were included in the study; healthy (n = 29), asthmatic (n = 18), and COPD (n = 10) for a total of 57 subjects. Reactance lung volume curves were generated via FOT recordings during two different breathing manoeuvres (both pre and post bronchodilator). The correlation and agreement between surrogate closing volume (Volcrit) and reactance (Xrscrit) at this volume was analysed. The changes in Volcrit and Xrscrit pre and post bronchodilator were also analysed. Across all three subject groups, the two different measures of Volcrit were shown to be statistically equivalent (p > 0.05) and demonstrated a strong fit to the data (R2 = 0.49, 0.78, 0.59, for asthmatic, COPD and healthy subject groups, respectively). A bias was evident between the two measurements of Xrscrit with statistically different means (p < 0.05). However, the two measurements of Xrscrit displayed the same trends. In conclusion, we have developed an alternative technique for measuring airway closure from FOT recordings. The technique delivers equivalent and possibly more sensitive results to previous methods while being simple and easily performed by the patient.

Airway closure, Forced oscillation technique, Lung de-recruitment, Reactance
1439-6319
2213-2224
Nilsen, K.
122aaae8-db6c-4edf-b46b-825b8b700fda
Gove, K.
8f043bbb-080d-49b3-9ee5-046f3a636ee0
Thien, F.
7196cba9-df37-461f-acf6-ff9318b88710
Wilkinson, T.
8c55ebbb-e547-445c-95a1-c8bed02dd652
Thompson, B. R.
0047c78d-c270-4c29-8db7-ec7178c69072
Nilsen, K.
122aaae8-db6c-4edf-b46b-825b8b700fda
Gove, K.
8f043bbb-080d-49b3-9ee5-046f3a636ee0
Thien, F.
7196cba9-df37-461f-acf6-ff9318b88710
Wilkinson, T.
8c55ebbb-e547-445c-95a1-c8bed02dd652
Thompson, B. R.
0047c78d-c270-4c29-8db7-ec7178c69072

Nilsen, K., Gove, K., Thien, F., Wilkinson, T. and Thompson, B. R. (2018) Comparison of two methods of determining lung de-recruitment, using the forced oscillation technique. European Journal of Applied Physiology, 118 (10), 2213-2224. (doi:10.1007/s00421-018-3949-1).

Record type: Article

Abstract

Airway closure has proved to be important in a number of respiratory diseases and may be the primary functional defect in asthma. A surrogate measure of closing volume can be identified using the forced oscillation technique (FOT), by performing a deflation maneuver and examining the resultant reactance (Xrs) lung volume relationship. This study aims to determine if a slow vital capacity maneuver can be used instead of this deflation maneuver and compare it to existing more complex techniques. Three subject groups were included in the study; healthy (n = 29), asthmatic (n = 18), and COPD (n = 10) for a total of 57 subjects. Reactance lung volume curves were generated via FOT recordings during two different breathing manoeuvres (both pre and post bronchodilator). The correlation and agreement between surrogate closing volume (Volcrit) and reactance (Xrscrit) at this volume was analysed. The changes in Volcrit and Xrscrit pre and post bronchodilator were also analysed. Across all three subject groups, the two different measures of Volcrit were shown to be statistically equivalent (p > 0.05) and demonstrated a strong fit to the data (R2 = 0.49, 0.78, 0.59, for asthmatic, COPD and healthy subject groups, respectively). A bias was evident between the two measurements of Xrscrit with statistically different means (p < 0.05). However, the two measurements of Xrscrit displayed the same trends. In conclusion, we have developed an alternative technique for measuring airway closure from FOT recordings. The technique delivers equivalent and possibly more sensitive results to previous methods while being simple and easily performed by the patient.

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More information

Accepted/In Press date: 21 July 2018
e-pub ahead of print date: 31 July 2018
Published date: October 2018
Keywords: Airway closure, Forced oscillation technique, Lung de-recruitment, Reactance

Identifiers

Local EPrints ID: 425789
URI: http://eprints.soton.ac.uk/id/eprint/425789
ISSN: 1439-6319
PURE UUID: 47498db5-23bf-4c84-a9a3-a4252e0aed6c

Catalogue record

Date deposited: 02 Nov 2018 17:30
Last modified: 09 Nov 2021 13:59

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Contributors

Author: K. Nilsen
Author: K. Gove
Author: F. Thien
Author: T. Wilkinson
Author: B. R. Thompson

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