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The changing face of asthma and its relation with microbes

The changing face of asthma and its relation with microbes
The changing face of asthma and its relation with microbes

During the past 50 years, the prevalence of asthma has increased and this has coincided with our changing relation with microorganisms. Asthma is a complex disease associated with local tissue inflammation of the airway that is determined by environmental, immunological, and host genetic factors. In a subgroup of sufferers, respiratory infections are associated with the development of chronic disease and more frequent inflammatory exacerbations. Recent studies suggest that these infections are polymicrobial in nature. Furthermore, there is increasing evidence that the recently discovered asthma airway microbiota may play a critical role in pathophysiological processes associated with the disease. Here, we discuss the current data regarding a possible role for infection in chronic asthma with a particular focus on the role bacteria may play. We discuss recent advances that are beginning to elucidate the complex relations between the microbiota and the immune response in asthma patients. We also highlight the clinical implications of these recent findings in regards to the development of novel therapeutic strategies.

Airway, Allergens, Asthma, Infection, Inflammation, Microbiota
0966-842X
408-418
Earl, Chris S.
7ac3a196-ab27-4687-9034-e58c752b7919
An, Shi Qi
0e05f480-cec1-4c0e-bc1d-359d30ea9a6e
Ryan, Robert P.
cd9f1e35-9ffe-456f-a64e-798b1f520298
Earl, Chris S.
7ac3a196-ab27-4687-9034-e58c752b7919
An, Shi Qi
0e05f480-cec1-4c0e-bc1d-359d30ea9a6e
Ryan, Robert P.
cd9f1e35-9ffe-456f-a64e-798b1f520298

Earl, Chris S., An, Shi Qi and Ryan, Robert P. (2015) The changing face of asthma and its relation with microbes. Trends in Microbiology, 23 (7), 408-418. (doi:10.1016/j.tim.2015.03.005).

Record type: Review

Abstract

During the past 50 years, the prevalence of asthma has increased and this has coincided with our changing relation with microorganisms. Asthma is a complex disease associated with local tissue inflammation of the airway that is determined by environmental, immunological, and host genetic factors. In a subgroup of sufferers, respiratory infections are associated with the development of chronic disease and more frequent inflammatory exacerbations. Recent studies suggest that these infections are polymicrobial in nature. Furthermore, there is increasing evidence that the recently discovered asthma airway microbiota may play a critical role in pathophysiological processes associated with the disease. Here, we discuss the current data regarding a possible role for infection in chronic asthma with a particular focus on the role bacteria may play. We discuss recent advances that are beginning to elucidate the complex relations between the microbiota and the immune response in asthma patients. We also highlight the clinical implications of these recent findings in regards to the development of novel therapeutic strategies.

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e-pub ahead of print date: 31 March 2015
Published date: 1 July 2015
Keywords: Airway, Allergens, Asthma, Infection, Inflammation, Microbiota

Identifiers

Local EPrints ID: 425822
URI: http://eprints.soton.ac.uk/id/eprint/425822
ISSN: 0966-842X
PURE UUID: 7015c7e9-61bb-471b-a7a0-321df698c208

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Date deposited: 05 Nov 2018 17:30
Last modified: 17 Mar 2024 12:13

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Contributors

Author: Chris S. Earl
Author: Shi Qi An
Author: Robert P. Ryan

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