The diffusible signal factor family of bacterial cell-cell signals
The diffusible signal factor family of bacterial cell-cell signals
Bacterial cell-to-cell signals of the diffusible signal factor (DSF) family are cis-2-unsaturated fatty acids that differ in their chain length and branching patterns. Signaling involving DSF family members occurs in diverse bacteria to include plant and human pathogens. In the majority of these organisms, the perception of DSF is linked to turnover of the second messenger cyclic di-GMP by one of two "core" pathways. Additional "accessory" signal transduction pathways can also be found, but are not widely conserved. DSF signaling acts to regulate diverse functions to include biofilm formation and architecture, antibiotic resistance, and the production of virulence factors in pathogens. DSF family signals can also participate in interspecies signaling with other bacteria and interkingdom signaling with the yeast Candida albicans. Such interactions may have importance in modifying microbial behavior during polymicrobial infections.
bacterial virulence, diffusible signal factors, fatty acids, regulation, signal transduction
321-329
Dow, J. Maxwell
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Naughton, Lynn M.
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Hollmann, Birte
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An, Shi Qi
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Ryan, Robert P.
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1 May 2016
Dow, J. Maxwell
a904f493-80b4-4868-999f-af843fff1063
Naughton, Lynn M.
f62cbbbc-0b5e-4bed-82cf-e355d3e216f9
Hollmann, Birte
982710a4-e0af-490c-a84c-8de1df3f7df5
An, Shi Qi
0e05f480-cec1-4c0e-bc1d-359d30ea9a6e
Ryan, Robert P.
cd9f1e35-9ffe-456f-a64e-798b1f520298
Dow, J. Maxwell, Naughton, Lynn M., Hollmann, Birte, An, Shi Qi and Ryan, Robert P.
(2016)
The diffusible signal factor family of bacterial cell-cell signals.
Israel Journal of Chemistry, 56 (5), .
(doi:10.1002/ijch.201500075).
Abstract
Bacterial cell-to-cell signals of the diffusible signal factor (DSF) family are cis-2-unsaturated fatty acids that differ in their chain length and branching patterns. Signaling involving DSF family members occurs in diverse bacteria to include plant and human pathogens. In the majority of these organisms, the perception of DSF is linked to turnover of the second messenger cyclic di-GMP by one of two "core" pathways. Additional "accessory" signal transduction pathways can also be found, but are not widely conserved. DSF signaling acts to regulate diverse functions to include biofilm formation and architecture, antibiotic resistance, and the production of virulence factors in pathogens. DSF family signals can also participate in interspecies signaling with other bacteria and interkingdom signaling with the yeast Candida albicans. Such interactions may have importance in modifying microbial behavior during polymicrobial infections.
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Accepted/In Press date: 21 December 2015
e-pub ahead of print date: 12 February 2016
Published date: 1 May 2016
Keywords:
bacterial virulence, diffusible signal factors, fatty acids, regulation, signal transduction
Identifiers
Local EPrints ID: 425827
URI: http://eprints.soton.ac.uk/id/eprint/425827
ISSN: 0021-2148
PURE UUID: 0ac5b19d-7073-4c0b-987c-62f42dc5a4e7
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Date deposited: 05 Nov 2018 17:30
Last modified: 17 Mar 2024 12:13
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Contributors
Author:
J. Maxwell Dow
Author:
Lynn M. Naughton
Author:
Birte Hollmann
Author:
Shi Qi An
Author:
Robert P. Ryan
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