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Functional and genomic insights into the pathogenesis of Burkholderia species to rice

Functional and genomic insights into the pathogenesis of Burkholderia species to rice
Functional and genomic insights into the pathogenesis of Burkholderia species to rice

A number of species of bacteria from the genus Burkholderia have been shown to be causal agents of diseases of rice. These diseases, caused by Burkholderia glumae, B.gladioli and B.plantarii, are becoming increasingly common across the globe. This is particularly so for B.glumae, whose ability to grow at elevated temperatures suggests that it may become a prevalent problem in an era of global warming. Despite the increasing threat to rice, relatively little is known about the virulence mechanisms employed by these pathogens. Work over the last 5 years has provided an increasing insight into these factors and their control by environmental and other cues. In addition, the determination of a number of genome sequences has allowed bioinformatic predictions of further possible mechanisms, which can now be investigated experimentally. Here, we review recent advances in the understanding of virulence of Burkholderia to rice, to include discussion of the roles of toxins, type II secreted enzymes, type III secreted effectors and motility as well as their regulation by quorum sensing, two-component systems and cyclic di-GMP signalling. Finally, we consider a number of approaches for the control of bacterial virulence through the modulation of quorum sensing and toxin degradation.

1462-2912
780-790
Naughton, Lynn M.
f62cbbbc-0b5e-4bed-82cf-e355d3e216f9
An, Shi Qi
0e05f480-cec1-4c0e-bc1d-359d30ea9a6e
Hwang, Ingyu
352e27de-d8b3-48c0-ab88-3696c4e6420f
Chou, Shan Ho
df90f6fe-5a0b-48ed-8fec-16cbf4ec4db7
He, Yong Qiang
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Tang, Ji Liang
74e46e1a-4f75-4c94-871d-317339f309f2
Ryan, Robert P.
cd9f1e35-9ffe-456f-a64e-798b1f520298
Dow, J. Maxwell
a904f493-80b4-4868-999f-af843fff1063
Naughton, Lynn M.
f62cbbbc-0b5e-4bed-82cf-e355d3e216f9
An, Shi Qi
0e05f480-cec1-4c0e-bc1d-359d30ea9a6e
Hwang, Ingyu
352e27de-d8b3-48c0-ab88-3696c4e6420f
Chou, Shan Ho
df90f6fe-5a0b-48ed-8fec-16cbf4ec4db7
He, Yong Qiang
054fa877-72e1-456d-85b2-fc607eba4700
Tang, Ji Liang
74e46e1a-4f75-4c94-871d-317339f309f2
Ryan, Robert P.
cd9f1e35-9ffe-456f-a64e-798b1f520298
Dow, J. Maxwell
a904f493-80b4-4868-999f-af843fff1063

Naughton, Lynn M., An, Shi Qi, Hwang, Ingyu, Chou, Shan Ho, He, Yong Qiang, Tang, Ji Liang, Ryan, Robert P. and Dow, J. Maxwell (2016) Functional and genomic insights into the pathogenesis of Burkholderia species to rice. Environmental Microbiology, 18 (3), 780-790. (doi:10.1111/1462-2920.13189).

Record type: Review

Abstract

A number of species of bacteria from the genus Burkholderia have been shown to be causal agents of diseases of rice. These diseases, caused by Burkholderia glumae, B.gladioli and B.plantarii, are becoming increasingly common across the globe. This is particularly so for B.glumae, whose ability to grow at elevated temperatures suggests that it may become a prevalent problem in an era of global warming. Despite the increasing threat to rice, relatively little is known about the virulence mechanisms employed by these pathogens. Work over the last 5 years has provided an increasing insight into these factors and their control by environmental and other cues. In addition, the determination of a number of genome sequences has allowed bioinformatic predictions of further possible mechanisms, which can now be investigated experimentally. Here, we review recent advances in the understanding of virulence of Burkholderia to rice, to include discussion of the roles of toxins, type II secreted enzymes, type III secreted effectors and motility as well as their regulation by quorum sensing, two-component systems and cyclic di-GMP signalling. Finally, we consider a number of approaches for the control of bacterial virulence through the modulation of quorum sensing and toxin degradation.

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More information

Accepted/In Press date: 13 December 2015
e-pub ahead of print date: 22 December 2015
Published date: 1 March 2016

Identifiers

Local EPrints ID: 425828
URI: http://eprints.soton.ac.uk/id/eprint/425828
ISSN: 1462-2912
PURE UUID: e052e08a-8af9-4025-9598-1b98cc36dd82

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Date deposited: 05 Nov 2018 17:30
Last modified: 15 Mar 2024 22:28

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Contributors

Author: Lynn M. Naughton
Author: Shi Qi An
Author: Ingyu Hwang
Author: Shan Ho Chou
Author: Yong Qiang He
Author: Ji Liang Tang
Author: Robert P. Ryan
Author: J. Maxwell Dow

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